Published in Antioxid Redox Signal on November 01, 2010
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal (2012) 5.65
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem (2011) 1.07
p53 and mitochondrial function in neurons. Biochim Biophys Acta (2014) 0.97
Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR. Aging Dis (2010) 0.95
Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice. J Physiol (2014) 0.95
Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis. Eur J Neurosci (2012) 0.91
Sulfhydration of p66Shc at cysteine59 mediates the antioxidant effect of hydrogen sulfide. Antioxid Redox Signal (2014) 0.90
NLRP5 mediates mitochondrial function in mouse oocytes and embryos. Biol Reprod (2012) 0.86
Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene. Mol Biol Cell (2014) 0.84
Hydrogen Sulfide and Cellular Redox Homeostasis. Oxid Med Cell Longev (2016) 0.82
Hypoxia-induced miR-210 modulates tissue response to acute peripheral ischemia. Antioxid Redox Signal (2013) 0.81
Mitochondrial ROS Metabolism: 10 Years Later. Biochemistry (Mosc) (2015) 0.81
Cardiac Hegemony of Senescence. Curr Transl Geriatr Exp Gerontol Rep (2013) 0.81
The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos. PLoS One (2014) 0.79
Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors. Curr Pharm Biotechnol (2013) 0.78
The role of MATER in endoplasmic reticulum distribution and calcium homeostasis in mouse oocytes. Dev Biol (2013) 0.78
P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan. Aging Cell (2016) 0.77
Mitochondrial quality control and age-associated arterial stiffening. Exp Gerontol (2014) 0.77
AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema. Oncotarget (2017) 0.75
Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors. J Biol Chem (2017) 0.75
Construction of p66Shc gene interfering lentivirus vectors and its effects on alveolar epithelial cells apoptosis induced by hyperoxia. Drug Des Devel Ther (2016) 0.75
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol (2008) 3.27
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons? Hum Mol Genet (2002) 2.05
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell (2013) 1.52
Crystal structure of the guanylyl cyclase Cya2. Proc Natl Acad Sci U S A (2008) 1.44
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryot Cell (2006) 1.41
A molecular mechanism for direct sirtuin activation by resveratrol. PLoS One (2012) 1.26
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization. J Mol Biol (2003) 1.19
Structure-based development of novel sirtuin inhibitors. Aging (Albany NY) (2011) 1.19
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc Natl Acad Sci U S A (2013) 1.18
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. PLoS Pathog (2010) 1.15
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison. Biol Chem (2003) 1.10
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency. Metabolism (2002) 1.08
Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase. Biochemistry (2008) 1.08
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem (2011) 1.07
An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms. Nat Commun (2013) 1.05
Activation of the lifespan regulator p66Shc through reversible disulfide bond formation. Proc Natl Acad Sci U S A (2008) 1.05
Sirt1 activation by resveratrol is substrate sequence-selective. Aging (Albany NY) (2013) 1.04
Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem (2008) 0.97
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition. PLoS One (2012) 0.96
Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array: evidence for a second binding site on monomeric actin. J Mol Biol (2006) 0.96
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. Proc Natl Acad Sci U S A (2014) 0.96
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia. Biochim Biophys Acta (2009) 0.95
Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets. Exp Gerontol (2010) 0.93
Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans. J Mol Biol (2008) 0.93
SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy (2015) 0.91
Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc. Aging (Albany NY) (2009) 0.90
Structures, substrates, and regulators of Mammalian sirtuins - opportunities and challenges for drug development. Front Pharmacol (2012) 0.90
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa. J Mol Biol (2011) 0.88
Crystal structure analysis of human Sirt2 and its ADP-ribose complex. J Struct Biol (2013) 0.88
Mutational analyses of the p35-caspase interaction. A bowstring kinetic model of caspase inhibition by p35. J Biol Chem (2002) 0.87
Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol. Biosci Rep (2013) 0.83
Identification of a haem domain in human soluble adenylate cyclase. Biosci Rep (2012) 0.83
Inhibition of the human deacylase Sirtuin 5 by the indole GW5074. Bioorg Med Chem Lett (2012) 0.81
Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism. Chem Biol (2013) 0.81
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions. Bioorg Med Chem Lett (2008) 0.81
Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism. Acta Crystallogr D Biol Crystallogr (2013) 0.81
New assays and approaches for discovery and design of Sirtuin modulators. Expert Opin Drug Discov (2014) 0.81
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model. ChemMedChem (2014) 0.80
The mitochondrial apoptosis pathway and p66Shc--a regulatory redox enzyme or an adapter protein snuggling around? Cell Cycle (2010) 0.80
Crystal structure of the putative adapter protein MTH1859. J Struct Biol (2004) 0.80
Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution. FEBS J (2014) 0.78
Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain. Biochem J (2007) 0.78
Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors. Angew Chem Int Ed Engl (2014) 0.78
Proteinase K improves quantitative acylation studies. Proteomics (2014) 0.78
Crystal structure of the GAF-B domain from human phosphodiesterase 5. Proteins (2011) 0.77
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides. Bioorg Med Chem (2009) 0.76
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol (2017) 0.75
Mechanism-based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl (2017) 0.75