Published in Free Radic Biol Med on January 01, 2000
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol (2007) 2.78
Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One (2011) 2.61
Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol (2002) 2.44
Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study. BMJ (2014) 2.26
Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? Epidemiol Rev (2013) 2.05
Telomere length assessment in human archival tissues: combined telomere fluorescence in situ hybridization and immunostaining. Am J Pathol (2002) 1.95
Telomeres shorten more slowly in long-lived birds and mammals than in short-lived ones. Proc Biol Sci (2003) 1.81
Telomere shortening and survival in free-living corvids. Proc Biol Sci (2009) 1.76
Telomeres and early-life stress: an overview. Biol Psychiatry (2012) 1.75
Telomere length, oxidative damage, antioxidants and breast cancer risk. Int J Cancer (2009) 1.70
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DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res (2007) 1.60
Telomere biology in healthy aging and disease. Pflugers Arch (2009) 1.41
Characterization of oxidative guanine damage and repair in mammalian telomeres. PLoS Genet (2010) 1.41
Differences in telomere length between homologous chromosomes in humans. Nucleic Acids Res (2001) 1.34
Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis. Cell Death Differ (2011) 1.23
Healthy lifestyle and leukocyte telomere length in U.S. women. PLoS One (2012) 1.23
Early life stress and telomere length: investigating the connection and possible mechanisms: a critical survey of the evidence base, research methodology and basic biology. Bioessays (2012) 1.23
Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer. Cancer Prev Res (Phila) (2009) 1.22
Effect of long-term hormone therapy on telomere length in postmenopausal women. Yonsei Med J (2005) 1.21
Longer telomeres associated with higher survival in birds. Biol Lett (2005) 1.18
Cellular senescence, ageing and disease. Age (Dordr) (2008) 1.17
Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways. Circ Res (2007) 1.16
Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. J Clin Invest (2013) 1.13
Senescent peritoneal mesothelial cells promote ovarian cancer cell adhesion: the role of oxidative stress-induced fibronectin. Am J Pathol (2009) 1.08
Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1. Nucleic Acids Res (2008) 1.06
Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population. Skelet Muscle (2011) 1.05
Short telomeres in short-lived males: what are the molecular and evolutionary causes? Aging Cell (2007) 1.04
Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation. Int J Mol Sci (2014) 1.00
The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses. Aging Cell (2014) 1.00
Telomeres and telomerase in the fetal origins of cardiovascular disease: a review. Hum Biol (2004) 1.00
Oxidative stress induces persistent telomeric DNA damage responsible for nuclear morphology change in mammalian cells. PLoS One (2014) 0.99
Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage. Biochem J (2004) 0.98
Regulation of senescence in cancer and aging. J Aging Res (2011) 0.98
Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts. Proc Natl Acad Sci U S A (2008) 0.95
Cellular senescence: unravelling complexity. Age (Dordr) (2009) 0.93
Tocotrienol-rich fraction prevents cell cycle arrest and elongates telomere length in senescent human diploid fibroblasts. J Biomed Biotechnol (2011) 0.92
Cognitive performance and leukocyte telomere length in two narrow age-range cohorts: a population study. BMC Geriatr (2010) 0.91
Telomeres and atherosclerosis. Cardiovasc J Afr (2012) 0.89
Coenzyme Q10 prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth. Mol Metab (2013) 0.88
Stress induced telomere shortening: longer life with less mutations? BMC Syst Biol (2014) 0.87
Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? Longev Healthspan (2014) 0.87
Zinc finger protein 637 protects cells against oxidative stress-induced premature senescence by mTERT-mediated telomerase activity and telomere maintenance. Cell Death Dis (2014) 0.86
Sex-related differences in length and erosion dynamics of human telomeres favor females. Aging (Albany NY) (2009) 0.86
A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations. PLoS One (2012) 0.84
DNA-PKcs inhibition sensitizes cancer cells to carbon-ion irradiation via telomere capping disruption. PLoS One (2013) 0.84
RECQL4 in genomic instability and aging. Trends Genet (2012) 0.84
Structural and functional association of androgen receptor with telomeres in prostate cancer cells. Aging (Albany NY) (2013) 0.83
Short telomere lengths in peripheral blood leukocytes are associated with an increased risk of oral premalignant lesion and oral squamous cell carcinoma. Cancer (2013) 0.82
Telomere Fragment Induced Amnion Cell Senescence: A Contributor to Parturition? PLoS One (2015) 0.82
Genome integrity is regulated by the Caenorhabditis elegans Rad51D homolog rfs-1. Genetics (2008) 0.81
High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort. Eur J Nutr (2014) 0.81
Lack of association of colonic epithelium telomere length and oxidative DNA damage in Type 2 diabetes under good metabolic control. BMC Endocr Disord (2008) 0.81
Stn1 is critical for telomere maintenance and long-term viability of somatic human cells. Aging Cell (2015) 0.80
Expression of telomerase activity and oxidative stress in human hepatocellular carcinoma with cirrhosis. World J Gastroenterol (2003) 0.80
Increased hepatic telomerase activity in a rat model of iron overload: a role for altered thiol redox state? Free Radic Biol Med (2006) 0.80
Attenuated expression of SECIS binding protein 2 causes loss of telomeric reserve without affecting telomerase. Exp Gerontol (2009) 0.80
Assessing telomere length using surface enhanced Raman scattering. Sci Rep (2014) 0.79
Impact of lifetime opioid exposure on arterial stiffness and vascular age: cross-sectional and longitudinal studies in men and women. BMJ Open (2014) 0.78
Stress and telomere shortening among central Indian conservation refugees. Proc Natl Acad Sci U S A (2015) 0.78
Comparison between two FISH techniques in the in vitro study of cytogenetic markers for low-dose X-ray exposure in human primary fibroblasts. Front Genet (2013) 0.78
P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan. Aging Cell (2016) 0.77
Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells. Chem Cent J (2012) 0.77
REAC technology and hyaluron synthase 2, an interesting network to slow down stem cell senescence. Sci Rep (2016) 0.77
Telomere Q-PNA-FISH--reliable results from stochastic signals. PLoS One (2014) 0.77
Identification and characterization of bovine regulator of telomere length elongation helicase gene (RTEL): molecular cloning, expression distribution, splice variants and DNA methylation profile. BMC Mol Biol (2007) 0.77
Genomic Changes in Normal Breast Tissue in Women at Normal Risk or at High Risk for Breast Cancer. Breast Cancer (Auckl) (2016) 0.77
Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage. Longev Healthspan (2013) 0.77
Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma. Mol Cancer (2015) 0.77
How Do Growth and Sibling Competition Affect Telomere Dynamics in the First Month of Life of Long-Lived Seabird? PLoS One (2016) 0.76
Interaction between Obstructive Sleep Apnea and Shortened Telomere Length on Brain White Matter Abnormality. Sleep (2016) 0.76
Telomere mean length in patients with diabetic retinopathy. Sci Rep (2015) 0.76
Placental telomere length and risk of placental abruption. J Matern Fetal Neonatal Med (2015) 0.75
Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage. Sci Rep (2017) 0.75
Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. J Biol Chem (2016) 0.75
Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers. Oncotarget (2016) 0.75
Pharmacological approaches to defining the role of chaperones in aging and prostate cancer progression. Cell Stress Chaperones (2002) 0.75
Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome. Sci Rep (2016) 0.75
Effects of oxygen, growth state, and senescence on the antioxidant responses of WI-38 fibroblasts. Age (Dordr) (2010) 0.75
Semen preparation methods and sperm telomere length: density gradient centrifugation versus the swim up procedure. Sci Rep (2016) 0.75
Transient ALT activation protects human primary cells from chromosome instability induced by low chronic oxidative stress. Sci Rep (2017) 0.75
The association of occupational metals exposure and oxidative damage, telomere shortening in fitness equipments manufacturing workers. Ind Health (2017) 0.75
Comparative resistance of the 20S and 26S proteasome to oxidative stress. Biochem J (1998) 1.82
Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones. Proc Natl Acad Sci U S A (1999) 1.56
Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome. J Biol Chem (1998) 1.28
Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress. Arch Biochem Biophys (2000) 1.21
Age-related changes in protein oxidation and proteolysis in mammalian cells. J Gerontol A Biol Sci Med Sci (2001) 1.14
Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases. Free Radic Biol Med (1997) 1.13
Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments. Oncogene (1999) 1.12
beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue. J Neuroimmunol (2001) 1.10
BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Radic Biol Med (2001) 1.10
Telomere length as a marker of oxidative stress in primary human fibroblast cultures. Ann N Y Acad Sci (2000) 1.01
Oxidized proteins as a marker of oxidative stress during coronary heart surgery. Free Radic Biol Med (1999) 1.00
4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease. Cell Mol Life Sci (2000) 0.93
Ferritin oxidation in vitro: implication of iron release and degradation by the 20S proteasome. IUBMB Life (2000) 0.91
Influence of DNA binding on the degradation of oxidized histones by the 20S proteasome. Arch Biochem Biophys (1999) 0.85
Hydrogen peroxide-mediated protein oxidation in young and old human MRC-5 fibroblasts. Arch Biochem Biophys (2000) 0.84
Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome. Free Radic Biol Med (1999) 0.82
LPS-induced protein oxidation and proteolysis in BV-2 microglial cells. IUBMB Life (2001) 0.80
Protein oxidation and proteolysis in RAW264.7 macrophages: effects of PMA activation. Biochim Biophys Acta (2001) 0.80
Dose- and wavelength-dependent oxidation of crystallins by UV light--selective recognition and degradation by the 20S proteasome. Free Radic Biol Med (1998) 0.80