Published in Sci Rep on March 15, 2016
A Study of LY2157299 in Participants With Hepatocellular Carcinoma | NCT01246986
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell (2009) 16.06
Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer (2008) 15.20
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell (2009) 13.09
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res (2007) 9.21
Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol (1999) 7.66
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43
Angiogenesis in brain tumours. Nat Rev Neurosci (2007) 6.82
Glioblastoma multiforme: the terminator. Proc Natl Acad Sci U S A (2000) 3.69
A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry. Brain (2010) 3.53
Essential protective roles of reactive astrocytes in traumatic brain injury. Brain (2006) 2.75
Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma. Cancer Res (2001) 1.99
Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion. J Natl Cancer Inst (2011) 1.86
Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia (2011) 1.78
TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer. J Clin Invest (2013) 1.76
Vasculogenic mimicry. APMIS (2004) 1.76
The brain tumor microenvironment. Glia (2012) 1.66
Purines, purinergic receptors, and cancer. Cancer Res (2012) 1.61
Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells. Cancer Res (2009) 1.55
Can tumor angiogenesis be inhibited without resistance? EXS (2005) 1.55
Absence of endothelial cells, central necrosis, and fibrosis are associated with aggressive inflammatory breast cancer. Cancer Res (2001) 1.53
Molecular pathways: vasculogenic mimicry in tumor cells: diagnostic and therapeutic implications. Clin Cancer Res (2012) 1.52
Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells. J Natl Cancer Inst (2004) 1.49
Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia. Cancer Res (2005) 1.49
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Oncogene (2012) 1.34
Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis. Clin Exp Metastasis (2010) 1.26
HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells. Free Radic Biol Med (2011) 1.17
Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activation. J Biol Chem (2012) 1.16
Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas. Br J Cancer (2002) 1.16
The clinical significance of tumor cell-lined vasculature in ovarian carcinoma: implications for anti-vasculogenic therapy. Cancer Biol Ther (2003) 1.15
First-in-human dose study of the novel transforming growth factor-β receptor I kinase inhibitor LY2157299 monohydrate in patients with advanced cancer and glioma. Clin Cancer Res (2014) 1.09
Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma. J Neuroinflammation (2011) 1.08
Environment, inflammation, and cancer. Curr Opin Genet Dev (2010) 1.06
Astrocytes enhance the invasion potential of glioblastoma stem-like cells. PLoS One (2013) 1.06
TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion. Cell Death Dis (2014) 1.04
Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer. Invest New Drugs (2014) 1.04
Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment. PLoS One (2012) 1.03
Overexpression of microtubule-associated protein-1 light chain 3 is associated with melanoma metastasis and vasculogenic mimicry. Tohoku J Exp Med (2011) 0.93
Astrocytes promote glioma invasion via the gap junction protein connexin43. Oncogene (2015) 0.90
Vasculogenic mimicry and its clinical significance in medulloblastoma. Cancer Biol Ther (2012) 0.90
Non-invasive quantification of brain tumor-induced astrogliosis. BMC Neurosci (2011) 0.88
Transforming growth factor-beta and its implication in the malignancy of gliomas. Target Oncol (2014) 0.87
Wnt3a Promotes the Vasculogenic Mimicry Formation of Colon Cancer via Wnt/β-Catenin Signaling. Int J Mol Sci (2015) 0.86
Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients. Oncotarget (2015) 0.85
The role of astrocytes in the progression of brain cancer: complicating the picture of the tumor microenvironment. Tumour Biol (2015) 0.78