Published in Proc Natl Acad Sci U S A on March 14, 2016
Liquid biopsies come of age: towards implementation of circulating tumour DNA. Nat Rev Cancer (2017) 0.88
New insights into the generation and role of de novo mutations in health and disease. Genome Biol (2016) 0.88
Origins, structures, and functions of circulating DNA in oncology. Cancer Metastasis Rev (2016) 0.87
The role of enhancers in cancer. Nat Rev Cancer (2016) 0.84
Nucleic acid biomarkers of β cell stress and death in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes (2016) 0.78
Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA. Nat Genet (2017) 0.78
Biomarkers of β-Cell Stress and Death in Type 1 Diabetes. Curr Diab Rep (2016) 0.77
CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA. Genome Biol (2017) 0.76
Evaluation of Methylation Biomarkers for Detection of Circulating Tumor DNA and Application to Colorectal Cancer. Genes (Basel) (2016) 0.76
Altered Striatocerebellar Metabolism and Systemic Inflammation in Parkinson's Disease. Oxid Med Cell Longev (2016) 0.76
Unmethylated Insulin DNA Is Elevated After Total Pancreatectomy With Islet Autotransplantation: Assessment of a Novel Beta Cell Marker. Am J Transplant (2016) 0.76
Epigenetic control of β-cell function and failure. Diabetes Res Clin Pract (2016) 0.75
A Minimally-invasive Blood-derived Biomarker of Oligodendrocyte Cell-loss in Multiple Sclerosis. EBioMedicine (2016) 0.75
DNA methylation patterns associated with oxidative stress in an ageing population. BMC Med Genomics (2016) 0.75
Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment. PLoS One (2016) 0.75
Emerging concepts in liquid biopsies. BMC Med (2017) 0.75
Circulating unmethylated insulin DNA as a potential non-invasive biomarker of beta cell death in type 1 Diabetes: a review and future prospect. Clin Epigenetics (2017) 0.75
Methylation-sensitive enrichment of minor DNA alleles using a double-strand DNA-specific nuclease. Nucleic Acids Res (2016) 0.75
Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies. Circ Cardiovasc Genet (2017) 0.75
Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes. Front Genet (2017) 0.75
Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death. J Vis Exp (2016) 0.75
Transplant genetics and genomics. Nat Rev Genet (2017) 0.75
5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages. Cell Res (2017) 0.75
Precision medicine based on epigenomics: the paradigm of carcinoma of unknown primary. Nat Rev Clin Oncol (2017) 0.75
Cell-Free DNA in Oncology: Gearing up for Clinic. Ann Lab Med (2018) 0.75
Liquid biopsies in lung cancer-time to implement research technologies in routine care? Ann Transl Med (2017) 0.75
Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol (2011) 25.66
Cancer genome landscapes. Science (2013) 25.33
Pancreatic cancer. N Engl J Med (2010) 13.88
International trial of the Edmonton protocol for islet transplantation. N Engl J Med (2006) 13.43
Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med (2013) 13.22
Presence of fetal DNA in maternal plasma and serum. Lancet (1997) 9.01
Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med (2014) 8.36
Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer (2011) 7.69
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature (2013) 7.42
DNA sequencing versus standard prenatal aneuploidy screening. N Engl J Med (2014) 6.66
Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol (2014) 4.76
Rapid clearance of fetal DNA from maternal plasma. Am J Hum Genet (1999) 3.39
Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11
DNA methylation dynamics in health and disease. Nat Struct Mol Biol (2013) 2.58
Insulin gene expression is regulated by DNA methylation. PLoS One (2009) 1.97
Transcriptomes of the major human pancreatic cell types. Diabetologia (2011) 1.90
Universal noninvasive detection of solid organ transplant rejection. Proc Natl Acad Sci U S A (2011) 1.78
Detection of β cell death in diabetes using differentially methylated circulating DNA. Proc Natl Acad Sci U S A (2011) 1.77
Pancreatic adenocarcinoma. N Engl J Med (2014) 1.67
Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem (1990) 1.60
Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury. Clin Chem (2013) 1.48
Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Nat Neurosci (2013) 1.39
Immune therapy and β-cell death in type 1 diabetes. Diabetes (2013) 1.33
Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: results of a pilot study. Resuscitation (2012) 1.31
β cell death and dysfunction during type 1 diabetes development in at-risk individuals. J Clin Invest (2015) 1.31
Visualization of early engraftment in clinical islet transplantation by positron-emission tomography. N Engl J Med (2007) 1.29
Cell-free DNA in serum and plasma: comparison of ELISA and quantitative PCR. Clin Chem (2005) 1.27
Novel methylated biomarkers and a robust assay to detect circulating tumor DNA in metastatic breast cancer. Cancer Res (2014) 1.19
Prognostic utility and characterization of cell-free DNA in patients with severe sepsis. Crit Care (2012) 1.18
Circulating cell-free DNA: an up-coming molecular marker in exercise physiology. Sports Med (2012) 1.10
Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments. Proc Natl Acad Sci U S A (2015) 1.10
S-100B is superior to NSE, BDNF and GFAP in predicting outcome of resuscitation from cardiac arrest with hypothermia treatment. Resuscitation (2010) 1.09
Cell-free DNA levels as a prognostic marker in acute myocardial infarction. Ann N Y Acad Sci (2006) 1.07
Comparison of the methylation patterns of the two rat insulin genes. J Biol Chem (1983) 1.05
Methylation of cell-free circulating DNA in the diagnosis of cancer. Front Mol Biosci (2015) 1.04
Neuromyelitis optica. Int MS J (2006) 1.03
Tissue-specific methylation of human insulin gene and PCR assay for monitoring beta cell death. PLoS One (2014) 1.02
Epigenetic alteration: new insights moving from tissue to plasma - the example of PCDH10 promoter methylation in colorectal cancer. Br J Cancer (2013) 0.94
A rapid noninvasive assay for the detection of renal transplant injury. Transplantation (2013) 0.93
Role of the blood-brain barrier in multiple sclerosis. Arch Med Res (2014) 0.89
Genome-wide DNA methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and Barrett esophagus. Neoplasia (2012) 0.88
The oligodendroglia cytoskeleton in health and disease. J Neurosci Res (2000) 0.86
Molecular alterations of the blood-brain barrier under inflammatory conditions: The role of endothelial to mesenchymal transition. Biochim Biophys Acta (2015) 0.86
Role of plasma DNA as a predictive marker of fatal outcome following severe head injury in males. J Neurotrauma (2007) 0.85
Severe traumatic brain injury in pediatric patients: treatment and outcome using an intracranial pressure targeted therapy--the Lund concept. Intensive Care Med (2005) 0.77
Assessment of responsiveness in acute cerebral disorders. A multicentre study on the reaction level scale (RLS 85). Acta Neurochir (Wien) (1988) 0.76
Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes. Proc Natl Acad Sci U S A (2014) 0.92