Published in Springerplus on February 24, 2016
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell (1994) 9.73
Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem (2001) 6.42
Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer (2009) 6.00
Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate. J Clin Oncol (2005) 5.55
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet (2006) 5.29
Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell (1995) 4.39
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med (2004) 4.28
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol (1996) 4.06
Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J Pharmacol Exp Ther (1990) 3.55
The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci (1998) 3.24
Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol (2004) 3.03
Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep (2008) 2.90
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators. Nat Med (2004) 2.90
Ezrin, a key component in tumor metastasis. Trends Mol Med (2004) 2.89
A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nat Cell Biol (2001) 2.45
Phospholipid signaling. Cell (1995) 2.43
Multidisciplinary utilization of dimethyl sulfoxide: pharmacological, cellular, and molecular aspects. Biochem Pharmacol (2003) 2.21
Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A (1999) 2.21
Phospholipase C(epsilon): a novel Ras effector. EMBO J (2001) 2.14
Metastasis-associated differences in gene expression in a murine model of osteosarcoma. Cancer Res (2001) 2.10
Childhood cancer survival trends in Europe: a EUROCARE Working Group study. J Clin Oncol (2005) 2.02
Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nat Neurosci (1999) 1.93
Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes. Clin Cancer Res (2005) 1.93
International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. Int J Cancer (2009) 1.91
Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. J Biol Chem (2000) 1.88
Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes. EMBO J (2000) 1.85
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res (2004) 1.84
Ezrin/radixin/moesin: versatile controllers of signaling molecules and of the cortical cytoskeleton. Int J Biochem Cell Biol (2007) 1.83
ERM proteins in epithelial cell organization and functions. Biochim Biophys Acta (2006) 1.80
Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas. Proc Natl Acad Sci U S A (1991) 1.77
A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway. J Biol Chem (2000) 1.67
Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation. Mol Biol Cell (2003) 1.67
Is there a relationship between phosphatidylinositol trisphosphate and F-actin polymerization in human neutrophils? J Biol Chem (1990) 1.65
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. Carcinogenesis (2009) 1.62
Phosphoinositide-specific phospholipase C and mitogenic signaling. Biochim Biophys Acta (1995) 1.61
Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44. Curr Biol (1998) 1.61
Spatial and temporal signalling by calcium. Curr Opin Cell Biol (1994) 1.54
shRNA targeting PLCε inhibits bladder cancer cell growth in vitro and in vivo. Urology (2011) 1.51
Cell signaling and cancer. Cancer Cell (2003) 1.50
Inositide-specific phospholipase c beta1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia. Leukemia (2004) 1.48
PLC regulation: emerging pictures for molecular mechanisms. Trends Biochem Sci (2010) 1.48
NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation. Neuron (1991) 1.46
Phospholipase C inhibitor, U73122, releases intracellular Ca2+, potentiates Ins(1,4,5)P3-mediated Ca2+ release and directly activates ion channels in mouse pancreatic acinar cells. Biochem J (1997) 1.45
Phospholipase C-mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane. J Cell Biol (2009) 1.41
Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy. Circ Res (2005) 1.41
Regulation of AP-3 function by inositides. Identification of phosphatidylinositol 3,4,5-trisphosphate as a potent ligand. J Biol Chem (1997) 1.33
Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. Hum Mol Genet (2012) 1.28
Phosphoinositides regulate membrane-dependent actin assembly by latex bead phagosomes. Mol Biol Cell (2002) 1.25
Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. Oncogene (2002) 1.24
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance. Prog Lipid Res (2010) 1.23
Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. Mol Cell Biol (2008) 1.21
U-73122, an aminosteroid phospholipase C antagonist, noncompetitively inhibits thyrotropin-releasing hormone effects in GH3 rat pituitary cells. Endocrinology (1992) 1.20
Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport. Proc Natl Acad Sci U S A (2004) 1.18
Current concepts on the molecular biology of osteosarcoma. Cancer Treat Res (2009) 1.18
High turnover of ezrin T567 phosphorylation: conformation, activity, and cellular function. Am J Physiol Cell Physiol (2007) 1.16
Up-regulated expression of Ezrin and c-Met proteins are related to the metastasis and prognosis of gastric carcinomas. Histol Histopathol (2011) 1.14
Phosphorylation of ezrin on threonine T567 plays a crucial role during compaction in the mouse early embryo. Dev Biol (2004) 1.11
Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets. J Biol Chem (1998) 1.10
Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell Signal (2012) 1.10
Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts. J Biol Chem (2005) 1.09
Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon. Mol Cell Biol (2005) 1.08
Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell line. Biochim Biophys Acta (2005) 1.07
Activation of protein kinase C in rat basophilic leukemia cells stimulates increased production of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: correlation with actin polymerization. Mol Biol Cell (1995) 1.04
Epithelial phosphatidylinositol-3-kinase signaling is required for β-catenin activation and host defense against Citrobacter rodentium infection. Infect Immun (2011) 1.02
RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line. Cancer Genet Cytogenet (2010) 1.01
Molecular mechanisms for focal adhesion assembly through regulation of protein-protein interactions. Structure (1996) 0.99
Multiple forms of phosphoinositide-specific phospholipase C and different modes of activation. Biochem Soc Trans (1991) 0.99
Ca2+ signalling mechanisms of the beta 2 integrin on neutrophils: involvement of phospholipase C gamma 2 and Ins(1,4,5)P3. Biochem J (1996) 0.97
Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma. Pediatr Blood Cancer (2008) 0.96
Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets (2011) 0.95
A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. J Biol Chem (1999) 0.94
Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells. PLoS One (2010) 0.94
Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease. Blood (2010) 0.93
Nonselective effects of the putative phospholipase C inhibitor, U73122, on adenosine A1 receptor-mediated signal transduction events in Chinese hamster ovary cells. Biochem Pharmacol (1998) 0.92
Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow. Biochem Pharmacol (1995) 0.92
Interaction of cytoskeletal proteins with membrane lipids. Int Rev Cytol (1998) 0.92
The interaction of U-73122 with the histamine H1 receptor: implications for the use of U-73122 in defining H1 receptor-coupled signalling pathways. Naunyn Schmiedebergs Arch Pharmacol (2000) 0.90
Phosphoinositide-specific phospholipase C: structural basis for catalysis and regulatory interactions. Semin Cell Dev Biol (1997) 0.90
Overexpression of activated phospholipase Cγ1 is a risk factor for distant metastases in T1-T2, N0 breast cancer patients undergoing adjuvant chemotherapy. Int J Cancer (2012) 0.89
BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells. Oncogene (2003) 0.89
Evidence for separate effects of U73122 on phospholipase C and calcium channels in human platelets. Biochem Pharmacol (1998) 0.89
Tumor suppressor role of phospholipase C epsilon in Ras-triggered cancers. Proc Natl Acad Sci U S A (2014) 0.89
Amplification of Ca2+ signaling by diacylglycerol-mediated inositol 1,4,5-trisphosphate production. J Biol Chem (2005) 0.89
Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth. J Biol Chem (2010) 0.88
Nuclear PLCbeta1 is required for 3T3-L1 adipocyte differentiation and regulates expression of the cyclin D3-cdk4 complex. Cell Signal (2009) 0.88
Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption. Eur J Clin Invest (2011) 0.87
Angiotensin II stimulates calcineurin activity in proximal tubule epithelia through AT-1 receptor-mediated tyrosine phosphorylation of the PLC-gamma1 isoform. J Am Soc Nephrol (2002) 0.87
Organ slices for the evaluation of human drug toxicity. Chem Biol Interact (2004) 0.87
Enhancement of ultraviolet B-induced skin tumor development in phospholipase Cε-knockout mice is associated with decreased cell death. Carcinogenesis (2010) 0.86
Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes activated after stimulation with lipopolysaccharide. J Cell Biochem (2010) 0.85
An examination of heme action in gene expression: heme and heme deficiency affect the expression of diverse genes in erythroid k562 and neuronal PC12 cells. DNA Cell Biol (2002) 0.85
The aminosteroid phospholipase C antagonist U-73122 (1-[6-[[17-beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) potently inhibits human 5-lipoxygenase in vivo and in vitro. Mol Pharmacol (2005) 0.85
PLCgamma2: where bone and immune cells find their common ground. Ann N Y Acad Sci (2010) 0.85
Phospholipase C isoforms are localized at the cleavage furrow during cytokinesis. J Biochem (2006) 0.84
Effects of U73122 and U73343 on human platelet calcium signalling and protein tyrosine phosphorylation. Biochim Biophys Acta (1997) 0.84
MYLK and MYL9 expression in non-small cell lung cancer identified by bioinformatics analysis of public expression data. Tumour Biol (2014) 0.84
Stimulation by parathyroid hormone of 45Ca2+ uptake in osteoblast-like cells: possible involvement of alkaline phosphatase. Endocrinology (1990) 0.84
Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis. J Immunol (2012) 0.84