Published in Oncogene on November 21, 2002
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Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
G-protein signaling: back to the future. Cell Mol Life Sci (2005) 2.38
Specificity in Ras and Rap signaling. J Biol Chem (2008) 1.62
Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. Biochem J (2004) 1.31
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. Mol Biol Cell (2007) 1.30
Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation. Proc Natl Acad Sci U S A (2007) 1.24
G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner. J Biol Chem (2005) 1.14
Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell Signal (2012) 1.10
Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon. Mol Cell Biol (2005) 1.08
Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice. J Physiol (2010) 1.07
Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc Natl Acad Sci U S A (2013) 0.98
Phospholipase C isozymes as effectors of Ras superfamily GTPases. J Lipid Res (2008) 0.92
Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1. Vitam Horm (2010) 0.91
Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3. Mol Cell Biol (2004) 0.89
Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca. PLoS Genet (2013) 0.88
Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF. J Cell Sci (2012) 0.83
Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma. PLoS One (2014) 0.81
Rap2B promotes migration and invasion of human suprarenal epithelioma. Tumour Biol (2014) 0.80
PLCε mediated sustained signaling pathways. Adv Biol Regul (2014) 0.78
Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras-associating Domains of Phospholipase Cϵ. J Biol Chem (2015) 0.78
A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis. Mol Carcinog (2013) 0.78
Filamin and Phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans Spermatheca. Worm (2013) 0.75
Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier. PLoS One (2016) 0.75
U-73122 reduces the cell growth in cultured MG-63 ostesarcoma cell line involving Phosphoinositide-specific Phospholipases C. Springerplus (2016) 0.75
The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression. J Cancer (2017) 0.75
AMID mediates adenosine-induced caspase-independent HuH-7 cell apoptosis. Cell Physiol Biochem (2011) 0.75
Structure, functional regulation and signaling properties of Rap2B. Oncol Lett (2016) 0.75
p53 upregulates PLCε-IP3-Ca(2+) pathway and inhibits autophagy through its target gene Rap2B. Oncotarget (2017) 0.75
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A (2013) 3.10
Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep (2008) 2.90
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci U S A (2007) 2.59
Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell (2003) 2.54
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res (2004) 1.84
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. Carcinogenesis (2009) 1.62
P53 codon 72 polymorphism contributes to breast cancer risk: a meta-analysis based on 39 case-control studies. Breast Cancer Res Treat (2009) 1.61
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal (2010) 1.52
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells. Proc Natl Acad Sci U S A (2002) 1.52
Lattice dynamics of the Zn-Mg-Sc icosahedral quasicrystal and its Zn-Sc periodic 1/1 approximant. Nat Mater (2007) 1.51
Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex. EMBO J (2003) 1.48
Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol (2007) 1.48
The effects of prostaglandin inhibition on whole-body ischemia-reperfusion in swine. Am J Emerg Med (2008) 1.40
Kinin B1 Receptor Antagonist BI113823 Reduces Acute Lung Injury. Crit Care Med (2015) 1.38
Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma. FASEB J (2010) 1.35
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. Mol Biol Cell (2007) 1.30
Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity. Neurochem Int (2009) 1.27
Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized on the plasma membrane of living cells. Chemphyschem (2003) 1.26
Structural basis for conformational dynamics of GTP-bound Ras protein. J Biol Chem (2010) 1.26
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester. Cancer Res (2008) 1.25
Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging. Biomaterials (2010) 1.24
Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo. J Biol Chem (2002) 1.21
Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases. J Biol Chem (2005) 1.21
Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells. Biol Cell (2008) 1.19
Modulation of early human preadipocyte differentiation by glucocorticoids. Endocrinology (2006) 1.16
Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. Proc Natl Acad Sci U S A (2007) 1.15
18F-Labeled magnetic-upconversion nanophosphors via rare-Earth cation-assisted ligand assembly. ACS Nano (2011) 1.11
Exposure of pregnant mice to carbon black by intratracheal instillation: toxicogenomic effects in dams and offspring. Mutat Res (2011) 1.09
Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon. Mol Cell Biol (2005) 1.08
Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers. J Biol Chem (2011) 1.07
Late-onset CMT2 associated with a novel missense mutation in the cytoplasmic domain of the MPZ gene. Clin Neurol Neurosurg (2010) 1.06
Targeted dual-contrast T1- and T2-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide nanoparticles. Biomaterials (2011) 1.06
Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans. Dev Biol (2004) 1.05
A novel functional polymorphism C1797G in the MDM2 promoter is associated with risk of bladder cancer in a Chinese population. Clin Cancer Res (2008) 1.03
Requirement of activated Cdc42-associated kinase for survival of v-Ras-transformed mammalian cells. Mol Cancer Res (2005) 1.03
Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome. Biochem Biophys Res Commun (2009) 1.02
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol Cell Biol (2008) 1.01
Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants. FEBS Lett (2012) 1.00
Genetic variation in PLCE1 is associated with gastric cancer survival in a Chinese population. J Gastroenterol (2011) 0.99
Increased brachial-ankle pulse wave velocity is independently associated with white matter hyperintensities. Neuroepidemiology (2011) 0.97
Neuronal lineage-specific induction of phospholipase Cepsilon expression in the developing mouse brain. Eur J Neurosci (2003) 0.96
Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics. Biochem Biophys Res Commun (2008) 0.95
An active nuclear retention signal in the glucocorticoid receptor functions as a strong inducer of transcriptional activation. J Biol Chem (2007) 0.94
Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites. Cell Signal (2004) 0.94
Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect. Eur J Neurosci (2009) 0.94
Amino acid sequence of the ligand-binding domain of the aryl hydrocarbon receptor 1 predicts sensitivity of wild birds to effects of dioxin-like compounds. Toxicol Sci (2012) 0.94
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5. Int J Cancer (2010) 0.94
Microwave-assisted extraction of polyphenols from Camellia oleifera fruit hull. Molecules (2011) 0.94
The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis. J Cancer Res Clin Oncol (2012) 0.93
Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins. J Biol Chem (2011) 0.93
Gd3+ complex-modified NaLuF4-based upconversion nanophosphors for trimodality imaging of NIR-to-NIR upconversion luminescence, X-Ray computed tomography and magnetic resonance. Biomaterials (2012) 0.92
IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation. J Immunol (2013) 0.92
A polymorphism (rs2295080) in mTOR promoter region and its association with gastric cancer in a Chinese population. PLoS One (2013) 0.92
Overexpression of Wld(S) or Nmnat2 in mauthner cells by single-cell electroporation delays axon degeneration in live zebrafish. J Neurosci Res (2010) 0.92
Dynamic polymorphism of Ras observed by single molecule FRET is the basis for molecular recognition. Biochem Biophys Res Commun (2006) 0.92
PLCε cooperates with the NF-κB pathway to augment TNFα-stimulated CCL2/MCP1 expression in human keratinocyte. Biochem Biophys Res Commun (2011) 0.91
Crucial role of phospholipase Cepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity. J Immunol (2009) 0.91
Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer. Cancer (2012) 0.91
Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells. PLoS One (2013) 0.91
Improved siderotic nodule detection in cirrhosis with susceptibility-weighted magnetic resonance imaging: a prospective study. PLoS One (2012) 0.90
Pulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage. Toxicology (2011) 0.90
Core-shell NaYF4:Yb3+,Tm3+@FexOy nanocrystals for dual-modality T2-enhanced magnetic resonance and NIR-to-NIR upconversion luminescent imaging of small-animal lymphatic node. Biomaterials (2011) 0.89
TERT polymorphisms modify the risk of acute lymphoblastic leukemia in Chinese children. Carcinogenesis (2012) 0.89
Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells. Cell Signal (2012) 0.88
Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung. Environ Mol Mutagen (2012) 0.88
The MPO -463G>A polymorphism and cancer risk: a meta-analysis based on 43 case-control studies. Mutagenesis (2010) 0.88
The behavior after intravenous injection in mice of multiwalled carbon nanotube / Fe3O4 hybrid MRI contrast agents. Biomaterials (2011) 0.88
Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells. Cell Signal (2013) 0.88
Phospholipase Cɛ has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC. Lab Invest (2011) 0.87
Structural analysis of triacylglycerols by using a MALDI-TOF/TOF system with monoisotopic precursor selection. J Am Soc Mass Spectrom (2012) 0.87
Genetic variation of CTNNB1 gene is associated with susceptibility and prognosis of gastric cancer in a Chinese population. Mutagenesis (2012) 0.87
Critical function of the Ras-associating domain as a primary Ras-binding site for regulation of Saccharomyces cerevisiae adenylyl cyclase. J Biol Chem (2001) 0.87
Detailed structural analysis of lipids directly on tissue specimens using a MALDI-SpiralTOF-Reflectron TOF mass spectrometer. PLoS One (2012) 0.87
FAS and FAS ligand polymorphisms in the promoter regions and risk of gastric cancer in Southern China. Biochem Genet (2009) 0.87
Insulin sensitization of human preadipocytes through glucocorticoid hormone induction of forkhead transcription factors. Mol Endocrinol (2009) 0.87
RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures. Neurosci Res (2011) 0.87