A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans.

PubWeight™: 4.03‹?› | Rank: Top 1%

🔗 View Article (PMID 2702689)

Published in Cell on April 07, 1989

Authors

V Ambros1

Author Affiliations

1: Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.

Articles citing this

A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA (2008) 6.86

The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell (2005) 5.90

Ordering gene function: the interpretation of epistasis in regulatory hierarchies. Trends Genet (1992) 3.65

Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics (1995) 3.07

fusca3: A Heterochronic Mutation Affecting Late Embryo Development in Arabidopsis. Plant Cell (1994) 3.06

daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans. Genes Dev (2000) 3.03

The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease. Cell Death Differ (2013) 2.41

A simple array platform for microRNA analysis and its application in mouse tissues. RNA (2007) 1.91

Genetic analysis reveals functional redundancy and the major target genes of the Arabidopsis miR159 family. Proc Natl Acad Sci U S A (2007) 1.83

NAViGaTing the micronome--using multiple microRNA prediction databases to identify signalling pathway-associated microRNAs. PLoS One (2011) 1.80

Temporal reiteration of a precise gene expression pattern during nematode development. EMBO J (1996) 1.60

C. elegans sym-1 is a downstream target of the hunchback-like-1 developmental timing transcription factor. Cell Cycle (2009) 1.50

The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3'UTR-mediated repression of the let-7 microRNA target gene, hbl-1. Dev Biol (2007) 1.46

Nuclear hormone receptor CHR3 is a critical regulator of all four larval molts of the nematode Caenorhabditis elegans. Proc Natl Acad Sci U S A (2001) 1.34

Characterization and expression patterns of let-7 microRNA in the silkworm (Bombyx mori). BMC Dev Biol (2007) 1.32

Identification of heterochronic mutants in Caenorhabditis elegans. Temporal misexpression of a collagen::green fluorescent protein fusion gene. Genetics (1998) 1.29

Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans. EMBO J (2006) 1.29

Identification of microRNAs with regulatory potential using a matched microRNA-mRNA time-course data. Nucleic Acids Res (2009) 1.24

The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis. Dev Biol (2008) 1.20

Transcriptional network underlying Caenorhabditis elegans vulval development. Proc Natl Acad Sci U S A (2005) 1.19

Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics (2001) 1.12

Dampening of expression oscillations by synchronous regulation of a microRNA and its target. Nat Genet (2013) 1.11

Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage. Genome Biol (2011) 1.09

MicroRNAs: new players in IBD. Gut (2014) 1.07

Genes that can be mutated to unmask hidden antigenic determinants in the cuticle of the nematode Caenorhabditis elegans. Proc Natl Acad Sci U S A (1990) 1.05

A developmental timing switch promotes axon outgrowth independent of known guidance receptors. PLoS Genet (2010) 1.04

lin-28 controls the succession of cell fate choices via two distinct activities. PLoS Genet (2012) 1.04

Molecular cloning of lin-29, a heterochronic gene required for the differentiation of hypodermal cells and the cessation of molting in C.elegans. Nucleic Acids Res (1991) 1.03

DAF-12 regulates a connected network of genes to ensure robust developmental decisions. PLoS Genet (2011) 1.02

Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1. Dev Biol (2009) 1.02

The Yin and Yang of microRNAs: leukemia and immunity. Immunol Rev (2013) 0.98

Evolution of the let-7 microRNA family. RNA Biol (2012) 0.97

CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans. Elife (2014) 0.97

MicroR159 regulation of most conserved targets in Arabidopsis has negligible phenotypic effects. Silence (2010) 0.96

LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning. Curr Biol (2010) 0.96

Regulation of lin-4 miRNA expression, organismal growth and development by a conserved RNA binding protein in C. elegans. Dev Biol (2010) 0.94

Computational prediction of the localization of microRNAs within their pre-miRNA. Nucleic Acids Res (2013) 0.94

MicroRNA-target interactions: new insights from genome-wide approaches. Ann N Y Acad Sci (2012) 0.93

Uncovering new functions for microRNAs in Caenorhabditis elegans. Curr Biol (2011) 0.92

Cell autonomous specification of temporal identity by Caenorhabditis elegans microRNA lin-4. Dev Biol (2010) 0.91

The Phytochemical Shikonin Stimulates Epithelial-Mesenchymal Transition (EMT) in Skin Wound Healing. Evid Based Complement Alternat Med (2013) 0.89

The elephant in the room: do microRNA-based therapies have a realistic chance of succeeding for brain tumors such as glioblastoma? J Neurooncol (2010) 0.88

Elements and machinery of non-coding RNAs: toward their taxonomy. EMBO Rep (2014) 0.88

Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes. BMC Syst Biol (2009) 0.87

Toward a unified model of developmental timing: A "molting" approach. Worm (2012) 0.86

New frontiers in heart hypertrophy during pregnancy. Am J Cardiovasc Dis (2012) 0.86

Altered expression of an L1-specific, O-linked cuticle surface glycoprotein in mutants of the nematode Caenorhabditis elegans. J Cell Biol (1991) 0.86

Transcriptional selectivity in early mouse embryos: a qualitative study. Nucleic Acids Res (1991) 0.85

Vascular and circulating microRNAs in renal ischaemia-reperfusion injury. J Physiol (2015) 0.85

Chronic nicotine exposure systemically alters microRNA expression profiles during post-embryonic stages in Caenorhabditis elegans. J Cell Physiol (2014) 0.85

microRNAs: the art of silencing in the ear. EMBO Mol Med (2012) 0.84

NOVOMIR: De Novo Prediction of MicroRNA-Coding Regions in a Single Plant-Genome. J Nucleic Acids (2010) 0.83

A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. elegans. RNA (2015) 0.83

Prediction of human miRNA target genes using computationally reconstructed ancestral mammalian sequences. Nucleic Acids Res (2016) 0.83

MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans. Development (2011) 0.82

A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport. Genes Dev (2016) 0.82

The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans. Genetics (2010) 0.82

MicroRNA-650 in a copy number-variable region regulates the production of interleukin 6 in human osteosarcoma cells. Oncol Lett (2015) 0.81

RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis elegans. Cell Cycle (2014) 0.81

The miR-302/367 cluster: a comprehensive update on its evolution and functions. Open Biol (2015) 0.80

Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression. Proc Natl Acad Sci U S A (2014) 0.78

Functional relevance of "seed" and "non-seed" sequences in microRNA-mediated promotion of C. elegans developmental progression. RNA (2015) 0.78

Inferring plant microRNA functional similarity using a weighted protein-protein interaction network. BMC Bioinformatics (2015) 0.77

How microRNAs modify protein production. J Invest Dermatol (2015) 0.77

Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2015) 0.77

An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem (2015) 0.77

miRNAs and their putative roles in the development and progression of Parkinson's disease. Front Genet (2013) 0.77

Formulation of New Algorithmics for miRNAs. Open Virol J (2008) 0.76

Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell (2016) 0.76

Deep sequencing of wheat sRNA transcriptome reveals distinct temporal expression pattern of miRNAs in response to heat, light and UV. Sci Rep (2016) 0.76

The evolutionary origin of plant and animal microRNAs. Nat Ecol Evol (2017) 0.76

Conserved behavioral and genetic mechanisms in the pre-hatching molt of the nematode Pristionchus pacificus. Evodevo (2014) 0.75

The ortholog of the human proto-oncogene ROS1 is required for epithelial development in C. elegans. Genesis (2013) 0.75

The 2006 Genetics Society of America Medal. Victor Ambros. Genetics (2006) 0.75

Lin28 and let-7: roles and regulation in liver diseases. Am J Physiol Gastrointest Liver Physiol (2016) 0.75

Stage-Specific Timing of the microRNA Regulation of lin-28 by the Heterochronic Gene lin-14 in Caenorhabditis elegans. Genetics (2016) 0.75

The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review). Int J Oncol (2015) 0.75

Post-transcriptional Regulation of BRCA2 through Interactions with miR-19a and miR-19b. Front Genet (2016) 0.75

Potential diagnostic implications of miR-144 overexpression in human oesophageal cancer. Indian J Med Res (2016) 0.75