Published in Oncogene on April 04, 2016
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol (2006) 13.12
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene (2007) 11.85
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell (2007) 7.99
The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol (2007) 6.16
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell (1994) 5.37
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res (2001) 4.73
Muscleblind proteins regulate alternative splicing. EMBO J (2004) 4.01
Aberrant activation of notch signaling in human breast cancer. Cancer Res (2006) 3.92
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol (2004) 3.87
Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science (1999) 3.74
Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci (2007) 3.13
Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci U S A (2009) 3.10
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem (2003) 2.94
Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell (2007) 2.83
numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell (1989) 2.72
Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls. Science (2010) 2.69
Numb is an endocytic protein. J Cell Biol (2000) 2.39
Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol (2008) 2.00
The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. EMBO J (2001) 1.92
Numb regulates post-endocytic trafficking and degradation of Notch1. J Biol Chem (2009) 1.89
Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. J Biol Chem (1999) 1.81
Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro. Oncogene (2007) 1.77
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun (2005) 1.65
Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage. Proc Natl Acad Sci U S A (1999) 1.54
Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience (1999) 1.54
Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer. Mol Cell Biol (2010) 1.53
Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta (2010) 1.50
Mouse numb is an essential gene involved in cortical neurogenesis. Proc Natl Acad Sci U S A (2000) 1.49
RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation. Mol Cell (2013) 1.47
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. Cancer Cell (2012) 1.44
Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate. Curr Biol (1996) 1.41
Notch signaling pathway as a therapeutic target in breast cancer. Mol Cancer Ther (2010) 1.39
Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC. Cell Rep (2012) 1.36
SFmap: a web server for motif analysis and prediction of splicing factor binding sites. Nucleic Acids Res (2010) 1.33
Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol Biol Cell (2011) 1.27
Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines. Brain (2009) 1.22
Multiple roles of mouse Numb in tuning developmental cell fates. Curr Biol (2001) 1.20
High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer. Proc Natl Acad Sci U S A (2013) 1.16
The RNA-binding protein QKI suppresses cancer-associated aberrant splicing. PLoS Genet (2014) 1.15
Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development. J Cell Biol (2013) 1.13
Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma. Mod Pathol (2006) 1.09
Nuclear RNA export and packaging functions of HIV-1 Rev revisited. J Virol (2010) 1.05
Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell (2006) 1.04
Expression of the splicing regulator polypyrimidine tract-binding protein in normal and neoplastic brain. Neuro Oncol (2004) 1.01
Exon array analysis using re-defined probe sets results in reliable identification of alternatively spliced genes in non-small cell lung cancer. BMC Genomics (2010) 1.01
Two novel human NUMB isoforms provide a potential link between development and cancer. Neural Dev (2010) 1.00
A switch in numb isoforms is a critical step in cortical development. Dev Dyn (2007) 0.99
Transgenic expression of numb inhibits notch signaling in immature thymocytes but does not alter T cell fate specification. J Immunol (2002) 0.98
Asymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio. Dev Dyn (2006) 0.97
Alternative splicing is frequent during early embryonic development in mouse. BMC Genomics (2010) 0.95
Transcriptome profiling of a multiple recurrent muscle-invasive urothelial carcinoma of the bladder by deep sequencing. PLoS One (2014) 0.93
Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties. Oncogenesis (2014) 0.93
PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis. Mol Carcinog (2011) 0.92
Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain. Dev Neurosci (2006) 0.88
HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells. PLoS One (2013) 0.87
Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas. Differentiation (2003) 0.86
Involvement of numb in vertebrate retinal development: evidence for multiple roles of numb in neural differentiation and maturation. J Neurobiol (2003) 0.86
NumbL is essential for Xenopus primary neurogenesis. BMC Dev Biol (2013) 0.76