Published in J Cell Mol Med on April 07, 2016
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet (2004) 42.12
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) Lancet (1994) 40.72
Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation (2012) 30.79
The mammalian epigenome. Cell (2007) 18.13
Switching from repression to activation: microRNAs can up-regulate translation. Science (2007) 17.00
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia (1992) 13.20
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
Transcriptional control of adipocyte formation. Cell Metab (2006) 9.50
Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A (2008) 8.39
RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. Nature (2006) 6.90
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev (2002) 6.46
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature (2010) 6.23
Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J (2006) 5.93
Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A (2003) 4.70
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect (2006) 4.46
Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med (2009) 4.44
Cancer epigenetics: modifications, screening, and therapy. Annu Rev Med (2008) 4.41
Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period. Eur J Hum Genet (2002) 4.33
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet (2009) 4.25
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05
Fetal nutrition and adult disease. Am J Clin Nutr (2000) 3.92
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science (2005) 3.80
PPARγ signaling and metabolism: the good, the bad and the future. Nat Med (2013) 3.71
MicroRNAs add a new dimension to cardiovascular disease. Circulation (2010) 3.64
Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study. Lancet (1999) 3.34
Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol (2010) 3.06
DNA methylation: the nuts and bolts of repression. J Cell Physiol (2007) 3.00
Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nat Rev Genet (2012) 2.93
Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev (2008) 2.89
Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev (2009) 2.40
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet (2012) 2.39
Metabolic requirements for the maintenance of self-renewing stem cells. Nat Rev Mol Cell Biol (2014) 2.36
RNA induction and inheritance of epigenetic cardiac hypertrophy in the mouse. Dev Cell (2008) 2.23
Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers. Mol Cell (2011) 2.12
Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology (2010) 2.10
Fetal origins of adult disease. Curr Probl Pediatr Adolesc Health Care (2011) 2.08
Non-genomic transgenerational inheritance of disease risk. Bioessays (2007) 2.07
Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genet (2006) 2.07
DNA methylation as a biomarker for cardiovascular disease risk. PLoS One (2010) 2.04
Environmental epigenetics. Heredity (Edinb) (2010) 1.99
Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation (2009) 1.92
Maternal high-fat diet effects on third-generation female body size via the paternal lineage. Endocrinology (2011) 1.85
The miR-124-Sox9 paramutation: RNA-mediated epigenetic control of embryonic and adult growth. Development (2009) 1.83
DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E. J Biol Chem (2004) 1.82
IGF-1, inflammation and stem cells: interactions during muscle regeneration. Trends Immunol (2005) 1.79
The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol (2009) 1.78
IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proc Natl Acad Sci U S A (2007) 1.77
IGF2: epigenetic regulation and role in development and disease. Cytokine Growth Factor Rev (2008) 1.73
Long-term reprogramming of cardiovascular function in infants of active smokers. Hypertension (2010) 1.73
Fetal origins of cardiovascular disease. Ann Med (1999) 1.70
Increased cardiac myocyte progenitors in failing human hearts. Circulation (2008) 1.68
p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively. J Biol Chem (1999) 1.66
Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care (2001) 1.63
DNA methylation and Rett syndrome. Hum Mol Genet (2003) 1.62
Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray. Circulation (2002) 1.58
A functional polymorphism of PON1 interferes with microRNA binding to increase the risk of ischemic stroke and carotid atherosclerosis. Atherosclerosis (2013) 1.56
Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy. Diabetes Care (2010) 1.55
OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases. FASEB J (2011) 1.53
Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans. Epigenetics (2011) 1.50
OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: novel mechanisms for cardiovascular diseases. J Mol Cell Cardiol (2011) 1.49
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet (2012) 1.47
Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. BMC Med (2013) 1.44
Meeting report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD). Pediatr Res (2007) 1.44
The marks, mechanisms and memory of epigenetic states in mammals. Biochem J (2001) 1.43
Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene. FASEB J (2009) 1.41
DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. Vasc Med (2002) 1.40
Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation. J Mol Cell Cardiol (2010) 1.37
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo. Endocrinology (2006) 1.36
Cardiovascular epigenetics: basic concepts and results from animal and human studies. Circ Cardiovasc Genet (2010) 1.33
Transgenerational epigenetic inheritance: how important is it? Nat Rev Genet (2013) 1.32
Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum. Nat Methods (2014) 1.31
miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes. FEBS Lett (2010) 1.28
Control of MyoD function during initiation of muscle differentiation by an autocrine signaling pathway activated by insulin-like growth factor-II. J Biol Chem (2006) 1.27
Metabolic programming of MEST DNA methylation by intrauterine exposure to gestational diabetes mellitus. Diabetes (2012) 1.25
Placental adiponectin gene DNA methylation levels are associated with mothers' blood glucose concentration. Diabetes (2012) 1.24
β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2014) 1.23
Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation (2011) 1.20
The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. Nutr Rev (2008) 1.20
Modulation of the PI 3-kinase-Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells. J Cell Sci (2006) 1.16
Fishing for the genetic basis of cardiovascular disease. Dis Model Mech (2009) 1.16
The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances. J Gerontol A Biol Sci Med Sci (2012) 1.14
Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle. Int J Biochem Cell Biol (2011) 1.10
Variable histone modifications at the A(vy) metastable epiallele. Epigenetics (2010) 1.09
CTCF binding at the insulin-like growth factor-II (IGF2)/H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues. Endocrinology (2003) 1.07
Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. Arterioscler Thromb Vasc Biol (2009) 1.07
Endogenous IGF-1 regulates the neuronal differentiation of adult stem cells. J Neurosci Res (2000) 1.05
Myostatin, the cardiac chalone of insulin-like growth factor-1. Cardiovasc Res (2005) 1.05
Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. Int J Obes (Lond) (2013) 1.05
Epigenetic codes of PPARγ in metabolic disease. FEBS Lett (2011) 1.04
Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks (Review). Int J Mol Med (2013) 1.03
ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia. Epigenetics (2012) 1.02
Maternal obesity induces epigenetic modifications to facilitate Zfp423 expression and enhance adipogenic differentiation in fetal mice. Diabetes (2013) 1.02
Epigenetic modifications in cardiovascular disease. Basic Res Cardiol (2012) 1.02
Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders. Epigenetics (2011) 1.01
Role of histone methylation and demethylation in adipogenesis and obesity. Organogenesis (2010) 1.01
Genetic mechanisms mediating atherosclerosis susceptibility at the chromosome 9p21 locus. Curr Atheroscler Rep (2011) 0.98
The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes Dev (2013) 0.98