Published in FASEB J on April 01, 2006
Allogeneic MSC Treatment for Pulmonary Emphysema | NCT04918706
Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res (2008) 8.49
Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ Res (2011) 4.75
Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov (2013) 4.35
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res (2010) 4.19
Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res (2013) 3.56
Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation (2010) 3.42
Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell (2012) 3.33
Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood (2008) 3.13
Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells (2008) 3.12
Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85
Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. Am J Respir Crit Care Med (2009) 2.83
Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. PLoS One (2007) 2.80
Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs. Nucleic Acids Res (2009) 2.66
Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med (2013) 2.60
Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Am J Respir Crit Care Med (2009) 2.60
Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase. Circulation (2009) 2.44
Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium. J Thorac Cardiovasc Surg (2015) 2.43
Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem Biophys Res Commun (2007) 2.35
VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart. Cardiovasc Res (2011) 2.30
Cardiac cell therapy: where we've been, where we are, and where we should be headed. Br Med Bull (2011) 2.26
Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair. J Am Coll Cardiol (2012) 2.18
Composite scaffold provides a cell delivery platform for cardiovascular repair. Proc Natl Acad Sci U S A (2011) 2.14
Stem cell paracrine actions and tissue regeneration. Regen Med (2010) 1.99
Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol (2010) 1.95
Mesenchymal stem cells for the treatment of neurodegenerative disease. Regen Med (2010) 1.89
Factors released from embryonic stem cells inhibit apoptosis of H9c2 cells. Am J Physiol Heart Circ Physiol (2007) 1.87
Myogenic endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infarcted myocardium. J Am Coll Cardiol (2008) 1.85
In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium. Arterioscler Thromb Vasc Biol (2011) 1.80
Myocardial AKT: the omnipresent nexus. Physiol Rev (2011) 1.76
Myocardial oxygenation and functional recovery in infarct rat hearts transplanted with mesenchymal stem cells. Am J Physiol Heart Circ Physiol (2009) 1.74
Long-term functional improvement and gene expression changes after bone marrow-derived multipotent progenitor cell transplantation in myocardial infarction. Am J Physiol Heart Circ Physiol (2010) 1.73
Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. Transplantation (2009) 1.73
Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation (2008) 1.68
Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol (2009) 1.64
Fate of culture-expanded mesenchymal stem cells in the microvasculature: in vivo observations of cell kinetics. Circ Res (2008) 1.62
Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc (2009) 1.62
Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells. BMC Cell Biol (2010) 1.62
Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem Cells (2009) 1.60
Cardiogenic differentiation and transdifferentiation of progenitor cells. Circ Res (2008) 1.54
Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc Natl Acad Sci U S A (2010) 1.51
Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction. Stem Cells (2009) 1.50
Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6. Stem Cell Res Ther (2011) 1.49
Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells. J Cell Mol Med (2010) 1.47
Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells. Am J Physiol Cell Physiol (2010) 1.47
CXCL14 and MCP1 are potent trophic factors associated with cell migration and angiogenesis leading to higher regenerative potential of dental pulp side population cells. Stem Cell Res Ther (2015) 1.46
Cardiac progenitor cell cycling stimulated by pim-1 kinase. Circ Res (2010) 1.46
Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action. Am J Physiol Lung Cell Mol Physiol (2012) 1.44
Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling. Stem Cells Dev (2010) 1.44
Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res (2008) 1.42
Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol (2012) 1.39
Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis. Fibrogenesis Tissue Repair (2008) 1.37
Hypoxia and stem cell-based engineering of mesenchymal tissues. Biotechnol Prog (2009) 1.36
Cell therapy for ischaemic heart disease: focus on the role of resident cardiac stem cells. Neth Heart J (2009) 1.35
Bone marrow stem cell derived paracrine factors for regenerative medicine: current perspectives and therapeutic potential. Bone Marrow Res (2010) 1.34
Bioenergetic and functional consequences of cellular therapy: activation of endogenous cardiovascular progenitor cells. Circ Res (2012) 1.34
Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circ Res (2013) 1.33
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper. J Extracell Vesicles (2015) 1.30
Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs. J Transl Med (2011) 1.29
Stem cells for myocardial repair with use of a transarterial catheter. Circulation (2009) 1.26
Differentiation of human bone marrow mesenchymal stem cells into bladder cells: potential for urological tissue engineering. Tissue Eng Part A (2010) 1.25
Empowering adult stem cells for myocardial regeneration. Circ Res (2011) 1.25
Cartilage repair: past and future--lessons for regenerative medicine. J Cell Mol Med (2009) 1.24
Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival. Am J Physiol Heart Circ Physiol (2010) 1.23
Survival and maturation of human embryonic stem cell-derived cardiomyocytes in rat hearts. J Mol Cell Cardiol (2007) 1.23
Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction. J Cell Mol Med (2011) 1.21
A fibrin patch-based enhanced delivery of human embryonic stem cell-derived vascular cell transplantation in a porcine model of postinfarction left ventricular remodeling. Stem Cells (2011) 1.18
Epidermal growth factor (EGF) treatment on multipotential stromal cells (MSCs). Possible enhancement of therapeutic potential of MSC. J Biomed Biotechnol (2010) 1.16
Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development (2008) 1.15
Improved survival of mesenchymal stromal cell after hypoxia preconditioning: role of oxidative stress. Life Sci (2010) 1.14
Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction. J Biomed Sci (2009) 1.13
Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century. Stem Cells Int (2015) 1.12
Benefits of hypoxic culture on bone marrow multipotent stromal cells. Am J Blood Res (2012) 1.11
Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease. Mol Neurobiol (2011) 1.11
A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods. J Transl Med (2014) 1.10
Enhanced recovery of mechanical function in the canine heart by seeding an extracellular matrix patch with mesenchymal stem cells committed to a cardiac lineage. Am J Physiol Heart Circ Physiol (2008) 1.10
The relative contribution of paracine effect versus direct differentiation on adipose-derived stem cell transplantation mediated cardiac repair. PLoS One (2013) 1.09
Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling. J Am Heart Assoc (2013) 1.09
Cellular and extracellular programming of cell fate through engineered intracrine-, paracrine-, and endocrine-like mechanisms. Biomaterials (2011) 1.08
Strategies for cardiac regeneration and repair. Sci Transl Med (2014) 1.08
Gene manipulated peritoneal cell patch repairs infarcted myocardium. J Mol Cell Cardiol (2009) 1.08
IL1β induces mesenchymal stem cells migration and leucocyte chemotaxis through NF-κB. Stem Cell Rev (2012) 1.07
Mesenchymal stem cells for vascular regeneration. Regen Med (2008) 1.06
Tissue-resident mesenchymal stem/progenitor cells in skeletal muscle: collaborators or saboteurs? FEBS J (2013) 1.05
Hypoxia-inducible vascular endothelial growth factor-engineered mesenchymal stem cells prevent myocardial ischemic injury. Mol Ther (2011) 1.05
Embryonic stem cells attenuate myocardial dysfunction and inflammation after surgical global ischemia via paracrine actions. Am J Physiol Heart Circ Physiol (2008) 1.05
Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells. Cell Transplant (2008) 1.05
Human embryonic stem cell-derived mesenchymal stromal cell transplantation in a rat hind limb injury model. Cytotherapy (2009) 1.05
Patching the heart: cardiac repair from within and outside. Circ Res (2013) 1.04
Activation of growth hormone releasing hormone (GHRH) receptor stimulates cardiac reverse remodeling after myocardial infarction (MI). Proc Natl Acad Sci U S A (2011) 1.04
c-kitpos GATA-4 high rat cardiac stem cells foster adult cardiomyocyte survival through IGF-1 paracrine signalling. PLoS One (2010) 1.03
Factors released from embryonic stem cells inhibit apoptosis in H9c2 cells through PI3K/Akt but not ERK pathway. Am J Physiol Heart Circ Physiol (2008) 1.02
Coronary vessel development and insight towards neovascular therapy. Int J Exp Pathol (2009) 1.00
Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs. Stem Cells (2009) 1.00
Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology. Dev Cell (2016) 0.99
Stem cells as drug delivery methods: application of stem cell secretome for regeneration. Adv Drug Deliv Rev (2014) 0.99
Bone marrow mesenchymal stem cells for post-myocardial infarction cardiac repair: microRNAs as novel regulators. J Cell Mol Med (2012) 0.99
Mesenchymal stem cell administration at coronary artery reperfusion in the rat by two delivery routes: a quantitative assessment. Life Sci (2008) 0.99
Paracrine effects of stem cells in wound healing and cancer progression (Review). Int J Oncol (2014) 0.99
Mesenchymal stromal cells for cardiovascular disease. J Cardiovasc Dis Res (2011) 0.98
Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res (2008) 8.49
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med (2003) 8.46
Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med (2005) 7.66
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab (2005) 4.65
Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery. J Am Coll Cardiol (2010) 4.53
Off-pump or on-pump coronary-artery bypass grafting at 30 days. N Engl J Med (2012) 4.32
Effects of off-pump and on-pump coronary-artery bypass grafting at 1 year. N Engl J Med (2013) 4.27
Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci U S A (2007) 3.74
MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. Circ Res (2012) 3.53
Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci (2002) 3.21
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest (2011) 2.99
Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol Ther (2006) 2.85
Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. Am J Respir Crit Care Med (2009) 2.83
Osseous abnormalities and early osteoarthritis: the role of hip impingement. Clin Orthop Relat Res (2004) 2.76
Predictors of postoperative movement and resting pain following total knee replacement. Pain (2012) 2.36
Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. Circulation (2003) 2.27
Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol Ther (2008) 2.25
Preoperative anxiety as a predictor of mortality and major morbidity in patients aged >70 years undergoing cardiac surgery. Am J Cardiol (2013) 2.18
A novel composite coronary bypass graft strategy: the saphenous vein bridge--a pilot study. Eur J Cardiothorac Surg (2013) 2.03
Therapeutic potential of endothelial progenitor cells in cardiovascular diseases. Hypertension (2005) 2.03
Implantation of CD133+ stem cells in patients undergoing coronary bypass surgery: IMPACT-CABG pilot trial. Can J Cardiol (2012) 2.02
Mechanisms for increased glycolysis in the hypertrophied rat heart. Hypertension (2004) 1.99
An initiative in mentoring to promote residents' and faculty members' careers. Acad Med (2004) 1.95
Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol (2010) 1.95
Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes. Hypertension (2006) 1.91
Atherosclerosis 2005: recent discoveries and novel hypotheses. Circulation (2005) 1.87
Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47(phox) gene expression in response to angiotensin II. Circ Res (2007) 1.79
Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. Mol Biol Cell (2007) 1.72
Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. Circulation (2002) 1.67
Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. Circ Res (2010) 1.60
Bone marrow-derived mesenchymal stem cells: isolation, expansion, characterization, viral transduction, and production of conditioned medium. Methods Mol Biol (2009) 1.60
Molecular genetics and genomics of heart failure. Nat Rev Genet (2004) 1.60
MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo. Magn Reson Med (2007) 1.57
Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiol Genomics (2002) 1.57
Diagnostic and prognostic value of presepsin in the management of sepsis in the emergency department: a multicenter prospective study. Crit Care (2013) 1.55
Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T. J Clin Invest (2003) 1.55
Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Nat Med (2006) 1.53
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell (2011) 1.52
Cell cycle-dependent regulation of smooth muscle cell activation. Arterioscler Thromb Vasc Biol (2004) 1.51
Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc Natl Acad Sci U S A (2010) 1.51
Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction. Stem Cells (2009) 1.50
Oncomodulin links inflammation to optic nerve regeneration. Proc Natl Acad Sci U S A (2009) 1.50
Angiogenesis and vasculogenesis in pregnancy. Eur J Obstet Gynecol Reprod Biol (2003) 1.48
Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. Circ Res (2006) 1.46
Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries. Circulation (2004) 1.46
Addition of frailty and disability to cardiac surgery risk scores identifies elderly patients at high risk of mortality or major morbidity. Circ Cardiovasc Qual Outcomes (2012) 1.41
Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. Circulation (2004) 1.41
Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest (2007) 1.40
Late retrograde perfusion of donor lungs does not decrease the severity of primary graft dysfunction. Ann Thorac Surg (2008) 1.39
Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray. Am J Pathol (2002) 1.38
Improving the health of the community: Duke's experience with community engagement. Acad Med (2008) 1.38
Impact of intracoronary injection of CD133+ bone marrow stem cells on coronary atherosclerotic progression in patients with STEMI: a COMPARE-AMI IVUS substudy. Coron Artery Dis (2016) 1.38
A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth. J Biol Chem (2006) 1.38
Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. J Mol Cell Cardiol (2008) 1.35
Bone marrow stem cell derived paracrine factors for regenerative medicine: current perspectives and therapeutic potential. Bone Marrow Res (2010) 1.34