Microenvironmental regulation of hematopoietic stem cells and its implications in leukemogenesis.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 27071022)

Published in Curr Opin Hematol on July 01, 2016

Authors

Madhav Seshadri1, Cheng-Kui Qu

Author Affiliations

1: Department of Pediatrics, Division of Hematology and Oncology, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA.

Articles cited by this

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00

Osteoblastic cells regulate the haematopoietic stem cell niche. Nature (2003) 19.60

Identification of the haematopoietic stem cell niche and control of the niche size. Nature (2003) 18.17

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature (2010) 15.28

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell (2004) 12.67

Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity (2006) 11.28

Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell (2006) 7.23

Endothelial and perivascular cells maintain haematopoietic stem cells. Nature (2012) 6.60

Haematopoietic stem cell release is regulated by circadian oscillations. Nature (2008) 6.50

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol (2005) 6.49

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature (2010) 5.43

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell (2007) 4.59

Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell (2007) 4.31

Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell (2010) 4.21

Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood (2005) 4.17

The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity (2010) 4.13

Detection of functional haematopoietic stem cell niche using real-time imaging. Nature (2008) 4.06

Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell (2011) 4.04

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature (2013) 4.04

Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A (2003) 3.98

Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell (2007) 3.82

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood (2010) 3.26

Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell (2014) 3.13

Arteriolar niches maintain haematopoietic stem cell quiescence. Nature (2013) 3.07

Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell (2011) 3.05

Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cell (2007) 2.96

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts. Nature (2014) 2.70

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature (2013) 2.62

Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med (2013) 2.48

SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell (2013) 2.47

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell (2013) 2.46

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nat Med (2012) 2.33

CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med (2013) 2.26

Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature (2014) 2.21

Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity (2003) 2.10

Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling. Nat Immunol (2007) 1.99

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner. Cell Stem Cell (2014) 1.81

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nat Med (2014) 1.68

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature (2015) 1.56

Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development. Blood (2015) 1.53

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med (2014) 1.52

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells. Blood (2012) 1.33

Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Rep (2013) 1.32

Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature (2014) 1.31

A role for leptin in sustaining lymphopoiesis and myelopoiesis. Proc Natl Acad Sci U S A (2008) 1.30

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation. Nature (2014) 1.29

The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function. Elife (2014) 1.28

Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche. Cell Stem Cell (2014) 1.27

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells. Blood (2010) 1.25

N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells. Stem Cell Res (2010) 1.16

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche. Nat Commun (2015) 0.95

Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow. EMBO J (2015) 0.84

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche. Cell Metab (2015) 0.84

PTPN13 and β-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche. Stem Cell Reports (2015) 0.78

PTPN13 regulates cellular signalling and β-catenin function during megakaryocytic differentiation. Biochim Biophys Acta (2014) 0.78

FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice. Leukemia (2015) 0.78

Obesity over the life course and risk of acute myeloid leukemia and myelodysplastic syndromes. Cancer Epidemiol (2015) 0.78

Articles by these authors

Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell (2013) 2.12

Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis. Nat Cell Biol (2009) 1.92

Protein tyrosine phosphatases in the JAK/STAT pathway. Front Biosci (2008) 1.63

Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells. J Biol Chem (2005) 1.54

Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. J Exp Med (2011) 1.37

Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP. EMBO J (2005) 1.36

Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling. Oncogene (2003) 1.28

A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol (2011) 1.18

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells. Blood (2010) 1.14

Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome. J Biol Chem (2002) 1.13

Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling. J Biol Chem (2005) 1.11

Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay. J Med Chem (2008) 1.11

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis. Aging (Albany NY) (2010) 1.08

SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG. Proc Natl Acad Sci U S A (2007) 1.07

Abnormal hematopoiesis in Gab2 mutant mice. Blood (2007) 1.04

Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration. Blood (2002) 1.00

A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival. Oncogene (2004) 0.96

DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase. J Biol Chem (2003) 0.95

Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression. J Leukoc Biol (2004) 0.94

Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis. J Biol Chem (2008) 0.93

Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis. J Signal Transduct (2011) 0.91

Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) potentiates cardiac contractility via activation of the ryanodine receptor. J Biol Chem (2010) 0.91

SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl. Blood (2006) 0.91

Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Mol Cell Biol (2002) 0.89

Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response. J Biol Chem (2003) 0.89

Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft. BMC Struct Biol (2007) 0.88

Complex systems biology approach to understanding coordination of JAK-STAT signaling. Biosystems (2007) 0.87

SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively. J Biol Chem (2005) 0.87

Immortalization of yolk sac-derived precursor cells. Blood (2002) 0.87

Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase. Proteins (2011) 0.86

Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1. J Immunol (2005) 0.86

Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies. Mol Cancer Ther (2013) 0.85

SHP-2 tyrosine phosphatase in human diseases. Int J Clin Exp Med (2009) 0.84

Chromosomal instability in in vitro cultured mouse hematopoietic cells associated with oxidative stress. Am J Blood Res (2012) 0.84

Primary T-tubule and autophagy defects in the phosphoinositide phosphatase Jumpy/MTMR14 knockout mice muscle. Adv Biol Regul (2012) 0.84

Molecular targets for the treatment of juvenile myelomonocytic leukemia. Adv Hematol (2011) 0.83

Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability. Cancer Res (2012) 0.83

In vitro hematopoietic differentiation of murine embryonic stem cells. Methods Mol Biol (2008) 0.82

Cited2, a transcriptional modulator protein, regulates metabolism in murine embryonic stem cells. J Biol Chem (2013) 0.82

Hepatocyte growth factor-induced proliferation of hepatic stem-like cells depends on activation of NF-kappaB. J Hepatol (2004) 0.82

Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11). J Med Chem (2013) 0.81

Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence. J Biol Chem (2013) 0.80

Phosphatidylcholine-specific phospholipase C activity is necessary for the activation of STAT6. J Immunol (2003) 0.80

Metabolic plasticity and hematopoietic stem cell biology. Curr Opin Hematol (2013) 0.80

Deficiency of MTMR14 promotes autophagy and proliferation of mouse embryonic fibroblasts. Mol Cell Biochem (2014) 0.79

Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts. Cell Signal (2006) 0.78

Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder. PLoS One (2013) 0.78

Rapid induction and activation of Tec tyrosine kinase in liver regeneration. J Gastroenterol Hepatol (2006) 0.76

Molecular-targeted therapies for hematologic malignancies. Adv Hematol (2011) 0.76

The hematopoietic stem cell landscape. Methods Mol Biol (2014) 0.75

Flow cytometric analysis of signaling and apoptosis in hematopoietic stem cells. Methods Mol Biol (2014) 0.75