Published in Stem Cells Int on March 17, 2016
Cardiac Regenerative Medicine: The Potential of a New Generation of Stem Cells. Transfus Med Hemother (2016) 0.79
Inspiration from heart development: Biomimetic development of functional human cardiac organoids. Biomaterials (2017) 0.75
Opportunities and challenges in phenotypic drug discovery: an industry perspective. Nat Rev Drug Discov (2017) 0.75
Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell (2003) 18.09
Vascular-specific growth factors and blood vessel formation. Nature (2000) 14.42
Evidence for cardiomyocyte renewal in humans. Science (2009) 14.17
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet (2012) 9.86
Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol (2006) 8.81
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation (2007) 8.62
Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res (2004) 8.41
Endothelial/pericyte interactions. Circ Res (2005) 8.24
The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol (2007) 7.38
Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell (2005) 7.07
Stem-cell therapy for cardiac disease. Nature (2008) 5.75
Tissue engineering--current challenges and expanding opportunities. Science (2002) 5.03
Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science (2001) 4.69
Stem cell niches in the adult mouse heart. Proc Natl Acad Sci U S A (2006) 4.58
Cell culture: biology's new dimension. Nature (2003) 4.51
Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res (2003) 4.39
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res (2010) 4.19
Spheroid-based drug screen: considerations and practical approach. Nat Protoc (2009) 4.01
Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci U S A (2005) 3.93
Cell therapy for cardiac repair--lessons from clinical trials. Nat Rev Cardiol (2014) 3.57
Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature (1977) 3.46
Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood (2008) 3.13
Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol Bioeng (2003) 3.04
Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. J Cell Biol (1998) 2.89
Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol J (2008) 2.82
Vascularized organoid engineered by modular assembly enables blood perfusion. Proc Natl Acad Sci U S A (2006) 2.82
Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proc Natl Acad Sci U S A (2010) 2.74
Engineering vascularized tissue. Nat Biotechnol (2005) 2.69
Mechanisms and models in heart failure: A combinatorial approach. Circulation (1999) 2.60
Systems approaches to preventing transplanted cell death in cardiac repair. J Mol Cell Cardiol (2008) 2.60
High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. Analyst (2010) 2.56
Biomaterials for the treatment of myocardial infarction. J Am Coll Cardiol (2006) 2.48
Organ printing: tissue spheroids as building blocks. Biomaterials (2009) 2.43
Concise review: mesenchymal stromal cells: potential for cardiovascular repair. Stem Cells (2008) 2.39
A simplified method for production and growth of multicellular tumor spheroids. Cancer Res (1977) 2.32
ECM signalling: orchestrating cell behaviour and misbehaviour. Trends Cell Biol (1998) 2.30
Cardiac cell therapy: where we've been, where we are, and where we should be headed. Br Med Bull (2011) 2.26
Three-dimensional tissue culture models in cancer biology. Semin Cancer Biol (2005) 2.26
Transplanted adult bone marrow cells repair myocardial infarcts in mice. Ann N Y Acad Sci (2001) 2.17
Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. J Am Coll Cardiol (2011) 2.15
Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair. Stem Cells (2010) 2.10
Intracoronary delivery of self-assembling heart-derived microtissues (cardiospheres) for prevention of adverse remodeling in a pig model of convalescent myocardial infarction. Circ Cardiovasc Interv (2015) 2.04
MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. J Biomed Mater Res A (2004) 2.03
Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair. Circulation (2010) 2.02
Assessment and optimization of cell engraftment after transplantation into the heart. Circ Res (2010) 1.90
Spheroid-based engineering of a human vasculature in mice. Nat Methods (2008) 1.90
Synergistic Effects of Combined Cell Therapy for Chronic Ischemic Cardiomyopathy. J Am Coll Cardiol (2015) 1.86
Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential. Tissue Eng Part C Methods (2010) 1.80
Endogenous cardiac stem cells. Prog Cardiovasc Dis (2007) 1.79
Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology. Int J Exp Pathol (1998) 1.70
Cell-cell signaling by direct contact increases cell proliferation via a PI3K-dependent signal. FEBS Lett (2002) 1.70
First evidence that bone marrow cells contribute to the construction of tissue-engineered vascular autografts in vivo. Circulation (2003) 1.69
Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels. Tissue Eng (2007) 1.69
Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction. Sci Transl Med (2013) 1.69
Mechanism of improved cardiac function after bone marrow mononuclear cell therapy: role of cardiovascular lineage commitment. Circulation (2010) 1.66
Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells (2012) 1.59
Culturing of human mesenchymal stem cells as three-dimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells. J Biol Chem (2008) 1.56
Microscale tissue engineering using gravity-enforced cell assembly. Trends Biotechnol (2004) 1.55
Engineering cellular microenvironments to improve cell-based drug testing. Drug Discov Today (2002) 1.54
Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells. Biomaterials (2011) 1.51
3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials (2009) 1.50
Regulating activation of transplanted cells controls tissue regeneration. Proc Natl Acad Sci U S A (2006) 1.46
Extracellular matrix: a dynamic microenvironment for stem cell niche. Biochim Biophys Acta (2014) 1.45
Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment. Stem Cells (2008) 1.45
Principals of neovascularization for tissue engineering. Mol Aspects Med (2002) 1.44
Mechanisms of cryoinjury in living cells. ILAR J (2000) 1.41
Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential. PLoS One (2015) 1.40
Spheroid culture as a tool for creating 3D complex tissues. Trends Biotechnol (2013) 1.40
Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers. Proc Natl Acad Sci U S A (1998) 1.37
Structural polarity and functional bile canaliculi in rat hepatocyte spheroids. Exp Cell Res (2002) 1.33
Human cardiospheres are a source of stem cells with cardiomyogenic potential. Stem Cells (2010) 1.33
Beta1 integrins participate in the hypertrophic response of rat ventricular myocytes. Circ Res (1998) 1.33
Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report. Eur Heart J (2015) 1.31
A critical appraisal of cryopreservation (slow cooling versus vitrification) of human oocytes and embryos. Hum Reprod Update (2012) 1.30
Design of custom-shaped vascularized tissues using microtissue spheroids as minimal building units. Tissue Eng (2006) 1.29
Allogeneic cardiospheres safely boost cardiac function and attenuate adverse remodeling after myocardial infarction in immunologically mismatched rat strains. J Am Coll Cardiol (2013) 1.28
A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. Lab Chip (2013) 1.27
Bioengineering heart muscle: a paradigm for regenerative medicine. Annu Rev Biomed Eng (2011) 1.26
Advances in the formation, use and understanding of multi-cellular spheroids. Expert Opin Biol Ther (2012) 1.25
Spherically symmetric mesenchymal stromal cell bodies inherent with endogenous extracellular matrices for cellular cardiomyoplasty. Stem Cells (2009) 1.25
Spheroids and cell survival. Crit Rev Oncol Hematol (2001) 1.25
The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities. Biomaterials (2011) 1.25
A novel concept for scaffold-free vessel tissue engineering: self-assembly of microtissue building blocks. J Biotechnol (2010) 1.22
Three-dimensional aggregates of mesenchymal stem cells: cellular mechanisms, biological properties, and applications. Tissue Eng Part B Rev (2013) 1.19
The effect of RGD peptide-conjugated magnetite cationic liposomes on cell growth and cell sheet harvesting. Biomaterials (2005) 1.17
Scaffold: a novel carrier for cell and drug delivery. Crit Rev Ther Drug Carrier Syst (2012) 1.15
384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids. Biotechnol Bioeng (2011) 1.15
Of layers and spheres: the reaggregate approach in tissue engineering. Trends Neurosci (2002) 1.14
Three-dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor. In Vitro Cell Dev Biol Anim (1997) 1.14
Intercellular ice propagation: experimental evidence for ice growth through membrane pores. Biophys J (2001) 1.14
The effect of continuous wavy micropatterns on silicone substrates on the alignment of skeletal muscle myoblasts and myotubes. Biomaterials (2006) 1.13
Design of artificial myocardial microtissues. Tissue Eng (2004) 1.12
Stem cell engraftment and survival in the ischemic heart. Ann Thorac Surg (2011) 1.09
Functional scaffold-free 3-D cardiac microtissues: a novel model for the investigation of heart cells. Am J Physiol Heart Circ Physiol (2012) 1.07
An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids. Biomaterials (2012) 1.05
Mass transfer limitations in embryoid bodies during human embryonic stem cell differentiation. Cells Tissues Organs (2012) 1.05
Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing. Hepatology (2012) 1.03
Long-term effects of chondrospheres on cartilage lesions in an autologous chondrocyte implantation model as investigated in the SCID mouse model. Int J Mol Med (2009) 1.02
Mesenchymal stromal cells derived from various tissues: Biological, clinical and cryopreservation aspects. Cryobiology (2015) 1.02