Published in Dev Cell on November 01, 2005
Hypoxia-inducible factors in physiology and medicine. Cell (2012) 8.16
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32
Hypoxia-inducible factors, stem cells, and cancer. Cell (2007) 5.96
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A (2007) 4.81
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest (2007) 4.80
Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev (2007) 4.46
The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol (2008) 4.43
The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ (2008) 4.31
Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci U S A (2008) 4.20
Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol (2010) 4.04
The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle (2009) 3.55
Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem (2009) 3.23
Hypoxia triggers meiotic fate acquisition in maize. Science (2012) 3.11
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest (2015) 2.93
Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell (2011) 2.80
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal (2013) 2.78
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res (2009) 2.69
Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res (2007) 2.51
The updated biology of hypoxia-inducible factor. EMBO J (2012) 2.49
Targeting Notch to target cancer stem cells. Clin Cancer Res (2010) 2.46
O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol (2010) 2.45
Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal (2014) 2.42
Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest (2010) 2.42
HIF1alpha delays premature senescence through the activation of MIF. Genes Dev (2006) 2.37
Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol (2006) 2.25
Hypoxia, notch signalling, and prostate cancer. Nat Rev Urol (2013) 2.24
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev (2012) 2.24
Hypoxia inducible factors in cancer stem cells. Br J Cancer (2010) 2.21
Biology of hypoxia-inducible factor-2alpha in development and disease. Cell Death Differ (2008) 2.08
Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta (2010) 2.00
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A (2008) 1.93
Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest (2008) 1.89
Emerging role of Notch in stem cells and cancer. Cancer Lett (2008) 1.88
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell (2010) 1.88
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A (2006) 1.87
Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br J Cancer (2009) 1.85
Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med (2009) 1.77
Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Renal Physiol (2010) 1.76
Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo. J Clin Invest (2008) 1.76
Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet (2009) 1.76
Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia. Mol Cell Biol (2007) 1.71
Medulloblastoma stem cells. J Clin Oncol (2008) 1.71
Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene (2010) 1.70
Not(ch) just development: Notch signalling in the adult brain. Nat Rev Neurosci (2011) 1.69
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene (2008) 1.61
The VHL tumor suppressor and HIF: insights from genetic studies in mice. Cell Death Differ (2008) 1.61
Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A (2011) 1.60
Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease. Arthritis Rheum (2011) 1.58
Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes. Curr Opin Genet Dev (2009) 1.57
Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest (2008) 1.56
Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer. Breast Cancer Res (2012) 1.55
Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55
Hypoxia-induced angiogenesis: good and evil. Genes Cancer (2011) 1.52
Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells. J Biol Chem (2008) 1.52
Molecular pathways: vasculogenic mimicry in tumor cells: diagnostic and therapeutic implications. Clin Cancer Res (2012) 1.52
Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta (2010) 1.50
Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J Clin Invest (2012) 1.50
Hypoxia-inducible factor signaling in the development of tissue fibrosis. Cell Cycle (2008) 1.49
Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res (2011) 1.48
Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis. J Biol Chem (2011) 1.48
High levels of Notch signaling down-regulate Numb and Numblike. J Cell Biol (2006) 1.47
Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells. Mol Cell Biol (2012) 1.47
Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev (2013) 1.47
HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells. Proc Natl Acad Sci U S A (2009) 1.46
Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells. Oncogene (2011) 1.41
HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. Cell Death Differ (2011) 1.40
Changes in primary lymphoid organs with aging. Semin Immunol (2012) 1.40
The molecular programme of tumour reversion: the steps beyond malignant transformation. Nat Rev Cancer (2009) 1.39
The functional role of Notch signaling in human gliomas. Neuro Oncol (2009) 1.39
Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet (2008) 1.36
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer. J Physiol (2013) 1.35
Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One (2012) 1.34
Mechanisms of neovascularization and resistance to anti-angiogenic therapies in glioblastoma multiforme. J Mol Med (Berl) (2013) 1.31
Role of stem cells in cardiovascular biology. J Thromb Haemost (2011) 1.31
Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation. Development (2012) 1.31
Hypoxia, HIFs and bone development. Bone (2010) 1.29
Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene (2009) 1.29
Inhibition of myogenesis by Notch: evidence for multiple pathways. J Cell Physiol (2009) 1.28
Hypoxia-inducible factors in stem cells and cancer. J Cell Mol Med (2009) 1.27
Notch3 is critical for proper angiogenesis and mural cell investment. Circ Res (2010) 1.27
TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype. J Cell Physiol (2010) 1.27
The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochim Biophys Acta (2012) 1.26
Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci U S A (2010) 1.25
Increased proliferation and analysis of differential gene expression in human Wharton's jelly-derived mesenchymal stromal cells under hypoxia. Int J Biol Sci (2010) 1.25
Low oxygen enhances primitive and definitive neural stem cell colony formation by inhibiting distinct cell death pathways. Stem Cells (2009) 1.23
Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity. Cancer Res (2009) 1.23
Cited2 is required for normal hematopoiesis in the murine fetal liver. Blood (2007) 1.21
Syndecan-3 and Notch cooperate in regulating adult myogenesis. J Cell Biol (2010) 1.21
Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin. Pigment Cell Melanoma Res (2009) 1.21
Notch inhibition as a promising new approach to cancer therapy. Adv Exp Med Biol (2012) 1.20
Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha. Diabetes (2009) 1.19
Hypoxic tumor microenvironment and cancer cell differentiation. Curr Mol Med (2009) 1.19
Modeling premature brain injury and recovery. Int J Dev Neurosci (2009) 1.18
Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Kidney Int (2009) 1.16
Interaction of hypoxia-inducible factor-1α and Notch signaling regulates medulloblastoma precursor proliferation and fate. Stem Cells (2010) 1.15
Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway. J Biol Chem (2010) 1.15
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms. Proc Natl Acad Sci U S A (2011) 1.14
Neural stem/progenitor cells promote endothelial cell morphogenesis and protect endothelial cells against ischemia via HIF-1alpha-regulated VEGF signaling. J Cereb Blood Flow Metab (2008) 1.14
Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. J Exp Med (2012) 1.14
FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J Biol Chem (2009) 1.14
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature (2008) 5.85
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01
Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci U S A (2008) 4.20
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell (2006) 4.01
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev (2008) 3.90
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Notch signaling: simplicity in design, versatility in function. Development (2011) 3.13
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J (2011) 2.71
Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol (2003) 2.47
Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci U S A (2002) 2.39
HIF1alpha delays premature senescence through the activation of MIF. Genes Dev (2006) 2.37
p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol (2002) 2.29
Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. Development (2003) 2.21
Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res (2008) 2.19
Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells. Circ Res (2008) 2.15
Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice. Proc Natl Acad Sci U S A (2008) 2.07
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab (2011) 2.02
Notch signaling in development and disease. Semin Cancer Biol (2004) 1.97
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A (2008) 1.93
Hypoxia inducible factor-2alpha in cancer. Cell Cycle (2007) 1.90
Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function. Diabetes (2004) 1.87
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling. Cancer Res (2007) 1.85
Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis (2003) 1.84
A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proc Natl Acad Sci U S A (2002) 1.82
Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet (2009) 1.76
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. J Biol Chem (2002) 1.74
PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A (2010) 1.71
PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci U S A (2009) 1.67
A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice. Cancer Res (2004) 1.64
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab (2010) 1.64
Characterization and clinical relevance of circulating and biopsy-derived endothelial progenitor cells in lymphoma patients. Haematologica (2007) 1.62
Hypoxia-inducible factor-1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance. Carcinogenesis (2003) 1.55
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci U S A (2002) 1.54
A nine-transmembrane domain topology for presenilin 1. J Biol Chem (2005) 1.52
High levels of Notch signaling down-regulate Numb and Numblike. J Cell Biol (2006) 1.47
Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state. Stem Cells (2010) 1.44
PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. Mod Pathol (2005) 1.42
Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J Neurotrauma (2002) 1.40
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc Natl Acad Sci U S A (2009) 1.40
Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas. J Clin Endocrinol Metab (2002) 1.38
Physiological activation of hypoxia inducible factor-1 in human skeletal muscle. FASEB J (2005) 1.37
Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells. J Biol Chem (2004) 1.31
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells. J Immunol (2003) 1.31
Immunohistochemical detection of nestin in pediatric brain tumors. J Histochem Cytochem (2002) 1.24
Hypoxia inducible factor regulates the cardiac expression and secretion of apelin. FASEB J (2007) 1.24
HIF-1alpha in endurance training: suppression of oxidative metabolism. Am J Physiol Regul Integr Comp Physiol (2007) 1.22
O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis. Nat Chem Biol (2012) 1.22
Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res (2003) 1.21
Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genet (2011) 1.20
Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein. J Biol Chem (2002) 1.19
A sensitive and quantitative assay for measuring cleavage of presenilin substrates. J Biol Chem (2001) 1.19
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex. J Biol Chem (2003) 1.19
TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells. J Immunol (2005) 1.17
Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer. FASEB J (2005) 1.16
Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp Cell Res (2004) 1.15
Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes Dev (2011) 1.15
Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability. Genes Chromosomes Cancer (2010) 1.14
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms. Proc Natl Acad Sci U S A (2011) 1.14
Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines. Exp Cell Res (2007) 1.14
Role of Islet1 in the patterning of murine dentition. Development (2003) 1.14
A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev (2013) 1.13
Recording Notch signaling in real time. Dev Neurosci (2006) 1.12
Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms. Curr Opin Genet Dev (2008) 1.11
Developmental toxicity screening in zebrafish. Birth Defects Res C Embryo Today (2011) 1.10
Role of CBP in regulating HIF-1-mediated activation of transcription. J Cell Sci (2004) 1.09
HIF-1 induction attenuates Nrf2-dependent IL-8 expression in human endothelial cells. Antioxid Redox Signal (2009) 1.09
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization. Mol Cell Biol (2006) 1.09
Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol (2003) 1.09
Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells. J Biol Chem (2007) 1.07
Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons. Development (2010) 1.07
Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1. Blood (2002) 1.06
[DNA ploidy is an independent prognostic biomarker in breast invasive ductal carcinoma]. Acta Med Port (2013) 1.06
Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product. J Biol Chem (2002) 1.05