Published in Neurobiol Aging on February 13, 2016
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta Neuropathol (2017) 0.75
ER stress and the unfolded protein response in neurodegeneration. Nat Rev Neurol (2017) 0.75
Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production. Front Pharmacol (2017) 0.75
Fine tuning PERK signaling for neuroprotection. J Neurochem (2017) 0.75
The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance. Front Mol Neurosci (2017) 0.75
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature (2002) 19.36
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med (2008) 17.09
LTP and LTD: an embarrassment of riches. Neuron (2004) 15.48
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron (2003) 14.03
Alzheimer's disease is a synaptic failure. Science (2002) 13.82
Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans (2006) 7.69
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science (2000) 5.28
Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng (2001) 4.64
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Sci Transl Med (2013) 4.62
Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron (2009) 3.94
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 3.61
Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature (2012) 3.54
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell (2007) 3.46
Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression. Neuron (2006) 3.37
Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. Nat Neurosci (2010) 2.99
Making synaptic plasticity and memory last: mechanisms of translational regulation. Genes Dev (2009) 2.90
Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Res (2002) 2.88
Biochemical mechanisms for translational regulation in synaptic plasticity. Nat Rev Neurosci (2004) 2.88
Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease. Neuron (2010) 2.67
Translational control and the unfolded protein response. Antioxid Redox Signal (2007) 2.47
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci (2013) 2.35
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci (2011) 2.33
A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci (2010) 2.22
PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Mol Biol Cell (2005) 1.88
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron (2013) 1.87
Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo. J Neurosci (2001) 1.50
Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One (2010) 1.49
Synaptic plasticity and translation initiation. Learn Mem (2004) 1.27
Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Rep (2012) 1.24
Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe. Genetics (2004) 1.17
Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. J Neurosci (2011) 1.14
NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus. Brain Res (2003) 1.11
Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice. J Neurosci (2012) 1.04
mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo. Nat Commun (2014) 0.98
Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease. J Neurochem (2011) 0.98
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia. Acta Neuropathol (2015) 0.97
Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β. J Neurosci (2014) 0.94
Synaptic plasticity disruption by amyloid beta protein: modulation by potential Alzheimer's disease modifying therapies. Biochem Soc Trans (2005) 0.94
The roles of protein expression in synaptic plasticity and memory consolidation. Front Mol Neurosci (2014) 0.87
The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem (2014) 0.86
Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory. Neurobiol Learn Mem (2013) 0.86
Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease. J Neurosci (2015) 0.84
PERK: a novel therapeutic target for neurodegenerative diseases? Alzheimers Res Ther (2014) 0.77
Deconstructing brain-derived neurotrophic factor actions in adult brain circuits to bridge an existing informational gap in neuro-cell biology. Neural Regen Res (2016) 0.78
RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease. Acta Neuropathol (2015) 0.78
Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice. Neuropsychopharmacology (2015) 0.76
Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease. J Alzheimers Dis (2016) 0.75