A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 27126989)

Published in Traffic on May 25, 2016

Authors

Radu Rapiteanu1, Luther J Davis2, James C Williamson1, Richard T Timms1, J Paul Luzio2, Paul J Lehner1

Author Affiliations

1: Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Wellcome Trust/MRC Building Biomedical Campus, Cambridge, CB2 0XY, UK.
2: Departments of Medicine and Clinical Biochemistry, University of Cambridge School of Clinical Medicine, Wellcome Trust/MRC Building Biomedical Campus, Cambridge, CB2 0XY, UK.

Articles cited by this

AKT/PKB signaling: navigating downstream. Cell (2007) 31.26

Genome engineering using the CRISPR-Cas9 system. Nat Protoc (2013) 15.98

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature (2008) 14.99

A hidden Markov model for predicting transmembrane helices in protein sequences. Proc Int Conf Intell Syst Mol Biol (1998) 14.18

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58

The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe (2008) 9.27

Rab conversion as a mechanism of progression from early to late endosomes. Cell (2005) 8.96

The WD repeat: a common architecture for diverse functions. Trends Biochem Sci (1999) 8.39

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature (2011) 5.68

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol (2008) 5.52

Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Traffic (2003) 5.32

Tetherin inhibits HIV-1 release by directly tethering virions to cells. Cell (2009) 5.06

Haploid genetic screens in human cells identify host factors used by pathogens. Science (2009) 4.91

Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. J Virol (2008) 4.72

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library. Nat Biotechnol (2013) 4.72

Inhibition of Lassa and Marburg virus production by tetherin. J Virol (2008) 3.98

Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism. J Virol (2009) 3.67

Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking. PLoS Pathog (2009) 3.66

Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion. Proc Natl Acad Sci U S A (2009) 3.47

Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J Virol (2010) 2.98

HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation. PLoS Pathog (2009) 2.92

Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion. PLoS Pathog (2009) 2.92

Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif. J Cell Sci (2007) 2.90

Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus. J Virol (2009) 2.87

Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments. J Virol (1994) 2.83

Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol Biol Cell (2001) 2.66

Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. Nat Genet (1996) 2.53

Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain. Cell Host Microbe (2010) 2.44

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis. J Biol Chem (1997) 2.42

HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes. J Biol Chem (2009) 2.42

Identification of the homologous beige and Chediak-Higashi syndrome genes. Nature (1996) 2.40

Suppression of Tetherin-restricting activity upon human immunodeficiency virus type 1 particle release correlates with localization of Vpu in the trans-Golgi network. J Virol (2009) 2.35

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nat Biotechnol (2011) 2.23

Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment. PLoS Pathog (2010) 2.12

Innate sensing of HIV-1 assembly by Tetherin induces NFκB-dependent proinflammatory responses. Cell Host Microbe (2012) 2.03

The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. PLoS Pathog (2010) 1.94

Human Vam6p promotes lysosome clustering and fusion in vivo. J Cell Biol (2001) 1.75

Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu. J Virol (2010) 1.67

Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps. PLoS Pathog (2010) 1.66

Determinants of tetherin antagonism in the transmembrane domain of the human immunodeficiency virus type 1 Vpu protein. J Virol (2010) 1.60

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Science (2015) 1.60

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef. Cell Host Microbe (2015) 1.58

Stimulation of NF-κB activity by the HIV restriction factor BST2. J Virol (2012) 1.56

Retroviral retention activates a Syk-dependent HemITAM in human tetherin. Cell Host Microbe (2014) 1.56

Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin. J Virol (2010) 1.48

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Mol Biol Cell (2014) 1.46

Structural insight into the mechanisms of enveloped virus tethering by tetherin. Proc Natl Acad Sci U S A (2010) 1.39

The role of mVps18p in clustering, fusion, and intracellular localization of late endocytic organelles. Mol Biol Cell (2003) 1.37

Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. J Biol Chem (2001) 1.37

The BEACH is hot: a LYST of emerging roles for BEACH-domain containing proteins in human disease. Traffic (2013) 1.35

The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals. J Virol (2014) 1.32

HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction. MBio (2011) 1.30

Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations. Proc Natl Acad Sci U S A (2010) 1.29

Diversity of WD-repeat proteins. Subcell Biochem (2008) 1.28

Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity. Proc Natl Acad Sci U S A (2014) 1.26

BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. PLoS Pathog (2009) 1.24

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2. Retrovirology (2014) 1.22

A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction. PLoS Pathog (2012) 1.21

HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells. J Virol (2014) 1.19

The antiviral activities of tetherin. Curr Top Microbiol Immunol (2013) 1.18

The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation. PLoS Pathog (2011) 1.18

Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogens. J Virol (2011) 1.14

Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction. Viruses (2011) 1.13

The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin. J Infect Dis (2011) 1.10

The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Structure (2012) 1.09

Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred. Genome Res (2011) 1.08

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release. Retrovirology (2011) 1.07

HIV-1 Vpu antagonizes BST-2 by interfering mainly with the trafficking of newly synthesized BST-2 to the cell surface. Traffic (2011) 1.06

Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu. J Virol (2011) 1.01

Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. Elife (2014) 0.99

Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells. PLoS One (2012) 0.98

The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion. Traffic (2012) 0.98

Rab7A is required for efficient production of infectious HIV-1. PLoS Pathog (2011) 0.97

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. Proc Natl Acad Sci U S A (2014) 0.91

Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes. Elife (2015) 0.90

Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases. PLoS Pathog (2013) 0.90

WDR81 is necessary for purkinje and photoreceptor cell survival. J Neurosci (2013) 0.89

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes. Traffic (2015) 0.88

Mechanisms underlying HIV-1 Vpu-mediated viral egress. Front Microbiol (2014) 0.86

Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. J Cell Biol (2016) 0.85

Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors. PLoS Pathog (2015) 0.85

RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking. Sci Rep (2014) 0.84

The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes. J Cell Sci (2015) 0.84

Inhibition of virus-like particle release of Sendai virus and Nipah virus, but not that of mumps virus, by tetherin/CD317/BST-2. Hiroshima J Med Sci (2012) 0.83

BST2/tetherin inhibits dengue virus release from human hepatoma cells. PLoS One (2012) 0.82