Functional modulation of glycine receptors by the alkaloid gelsemine.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27128379)

Published in Br J Pharmacol on June 06, 2016

Authors

Cesar O Lara1, Pablo Murath1, Braulio Muñoz1, Ana M Marileo1, Loreto San Martín1, Victoria P San Martín1, Carlos F Burgos1, Trinidad A Mariqueo2, Luis G Aguayo1, Jorge Fuentealba1, Patricio Godoy3, Leonardo Guzman1, Gonzalo E Yévenes1

Author Affiliations

1: Department of Physiology, Faculty of Biological Sciences, University of Concepcion, Chile.
2: Department of Pharmacology, School of Medicine, University of Talca, Chile.
3: IfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.

Articles cited by this

Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol (2010) 17.30

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Res (2015) 10.66

Experimental design and analysis and their reporting: new guidance for publication in BJP. Br J Pharmacol (2015) 5.43

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP. Br J Pharmacol (2015) 4.46

Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci (2005) 4.07

Molecular structure and function of the glycine receptor chloride channel. Physiol Rev (2004) 3.77

GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science (2004) 3.38

The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol (2015) 2.74

The glycinergic inhibitory synapse. Cell Mol Life Sci (2001) 2.50

Native glycine receptor subtypes and their physiological roles. Neuropharmacology (2008) 2.06

Presynaptic glycine receptors enhance transmitter release at a mammalian central synapse. Nature (2001) 1.94

Allosteric potentiation of glycine receptor chloride currents by glutamate. Nat Neurosci (2010) 1.52

The genetics of hyperekplexia: more than startle! Trends Genet (2008) 1.49

Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci (2014) 1.49

Fast synaptic inhibition in spinal sensory processing and pain control. Physiol Rev (2012) 1.45

Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature (2015) 1.41

The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study. Br J Pharmacol (1997) 1.37

Gephyrin: a master regulator of neuronal function? Nat Rev Neurosci (2014) 1.36

Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors. J Biol Chem (2005) 1.35

Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization. Science (2009) 1.34

Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+. Mol Pharmacol (1994) 1.32

Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors. J Physiol (2000) 1.32

The Concise Guide to PHARMACOLOGY 2015/16: Ligand-gated ion channels. Br J Pharmacol (2015) 1.30

Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice. J Clin Invest (2010) 1.21

Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy. J Cell Mol Med (2008) 1.18

A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol. Proc Natl Acad Sci U S A (2008) 1.17

Modulation of glycine-activated ion channel function by G-protein betagamma subunits. Nat Neurosci (2003) 1.16

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med (2012) 1.11

Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control. Annu Rev Pharmacol Toxicol (2011) 1.11

Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Mol Pharmacol (2005) 1.07

Medicinal plants of the genus Gelsemium (Gelsemiaceae, Gentianales)--a review of their phytochemistry, pharmacology, toxicology and traditional use. J Ethnopharmacol (2014) 1.07

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine. Nature (2015) 1.06

Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor alpha3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin injection. Pain (2006) 1.06

Glycine and glycine receptor signaling in hippocampal neurons: diversity, function and regulation. Prog Neurobiol (2010) 1.06

GABAA and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids. J Physiol (2007) 1.05

Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochem Pharmacol (2008) 1.05

Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation. J Biol Chem (2010) 1.03

Changes in the properties of developing glycine receptors in cultured mouse spinal neurons. Synapse (1998) 1.01

Allosteric modulation of glycine receptors. Br J Pharmacol (2011) 1.01

Antianxiety activity of Gelsemium sempervirens. Pharm Biol (2010) 1.01

A single beta subunit M2 domain residue controls the picrotoxin sensitivity of alphabeta heteromeric glycine receptor chloride channels. J Neurochem (2001) 1.01

Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine. Neuroscience (2008) 0.97

Pharmacological effect and toxicity of alkaloids from Gelsemium elegans Benth. J Ethnopharmacol (2003) 0.95

Changes on the properties of glycine receptors during neuronal development. Brain Res Brain Res Rev (2004) 0.95

Activation of presynaptic glycine receptors facilitates glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus neurons. J Physiol (2003) 0.94

Developmental-dependent action of microtubule depolymerization on the function and structure of synaptic glycine receptor clusters in spinal neurons. J Neurophysiol (2003) 0.91

Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors. Pain (2013) 0.91

The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics. Psychopharmacology (Berl) (2012) 0.90

Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids. PLoS One (2011) 0.90

Early history of glycine receptor biology in Mammalian spinal cord circuits. Front Mol Neurosci (2010) 0.88

Long-term potentiation of glycinergic synapses triggered by interleukin 1β. Proc Natl Acad Sci U S A (2014) 0.85

Pharmacological effect of gelsemine on anxiety-like behavior in rat. Behav Brain Res (2013) 0.83

Glycine receptor beta subunits play a critical role in potentiation of glycine responses by ICS-205,930. Mol Pharmacol (2000) 0.81

Potentiation of chloride responses to glycine by three 5-HT3 antagonists in rat spinal neurones. Br J Pharmacol (1996) 0.80

The kinetic properties of the α3 rat glycine receptor make it suitable for mediating fast synaptic inhibition. J Physiol (2013) 0.80

Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons. J Neurophysiol (2014) 0.80

Strychnine-sensitive glycine receptors on pyramidal neurons in layers II/III of the mouse prefrontal cortex are tonically activated. J Neurophysiol (2014) 0.79

Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex. J Physiol (2012) 0.78

Presynaptic glycine receptors increase GABAergic neurotransmission in rat periaqueductal gray neurons. Neural Plast (2013) 0.78

Antitumor activity of two gelsemine metabolites in rat liver microsomes. J Asian Nat Prod Res (2010) 0.77

Glycine receptor-mediated inhibition of medial prefrontal cortical pyramidal cells. Biochem Biophys Res Commun (2014) 0.76