Published in Br J Pharmacol on December 01, 1997
General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci (1999) 2.43
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel. Anesth Analg (2009) 2.15
Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacol Ther (2007) 1.60
Activation and block of recombinant GABA(A) receptors by pentobarbitone: a single-channel study. Br J Pharmacol (2000) 1.19
The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. Br J Pharmacol (2000) 1.16
Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem (2012) 1.07
Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA. Biophys J (2009) 1.07
Allosteric modulation of glycine receptors. Br J Pharmacol (2011) 1.01
Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation. Br J Pharmacol (1999) 1.01
Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors. Anesthesiology (2009) 0.99
Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin. Front Mol Neurosci (2012) 0.98
Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells. Mol Pharmacol (2009) 0.95
Activation of presynaptic glycine receptors facilitates glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus neurons. J Physiol (2003) 0.94
p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem (2010) 0.93
Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans. Br J Pharmacol (2003) 0.92
A Single phenylalanine residue in the main intracellular loop of α1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol. Anesthesiology (2011) 0.92
Brain-state-independent neural representation of peripheral stimulation in rat olfactory bulb. Proc Natl Acad Sci U S A (2011) 0.89
Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. Mol Pain (2005) 0.88
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain. J Pharmacol Exp Ther (2013) 0.87
Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J Biol Chem (2012) 0.85
GABAA-positive modulator selective discriminative stimulus effects of 1,1,1-trichloroethane vapor. Drug Alcohol Depend (2011) 0.80
Reversal of ion-charge selectivity renders the pentameric ligand-gated ion channel GLIC insensitive to anaesthetics. Biochem J (2013) 0.80
4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors. BMC Neurol (2012) 0.80
During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons. Neuropharmacology (2015) 0.79
Dynamic loss of surface-expressed AMPA receptors in mouse cortical and striatal neurons during anesthesia. J Neurosci Res (2011) 0.79
Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes. PLoS One (2015) 0.77
Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits. PLoS One (2012) 0.77
Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: a patch clamp study. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.77
Structural features of phenol derivatives determining potency for activation of chloride currents via alpha(1) homomeric and alpha(1)beta heteromeric glycine receptors. Br J Pharmacol (2005) 0.77
Effects of different anesthetics on oscillations in the rat olfactory bulb. J Am Assoc Lab Anim Sci (2012) 0.76
Selective potentiation of alpha 1 glycine receptors by ginkgolic acid. Front Mol Neurosci (2015) 0.76
Mode of action of ICS 205,930, a novel type of potentiator of responses to glycine in rat spinal neurones. Br J Pharmacol (1999) 0.76
Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol. Br J Pharmacol (2016) 0.75
Functional modulation of glycine receptors by the alkaloid gelsemine. Br J Pharmacol (2016) 0.75
Bursting as a source of non-linear determinism in the firing patterns of nigral dopamine neurons. Eur J Neurosci (2012) 0.75
Guide to Receptors and Channels (GRAC), 3rd edition. Br J Pharmacol (2008) 13.18
The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature (1999) 2.91
The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. Proc Natl Acad Sci U S A (1997) 2.73
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor. Br J Pharmacol (1997) 2.08
Neurosteroids and GABAA receptor function. Trends Pharmacol Sci (1995) 1.87
The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. Br J Pharmacol (1991) 1.81
Guide to Receptors and Channels (GRAC), 2nd edition (2007 Revision). Br J Pharmacol (2007) 1.56
The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques. Br J Pharmacol (1989) 1.54
Modulation of the GABAA receptor by progesterone metabolites. Proc R Soc Lond B Biol Sci (1987) 1.48
Closure of membrane channels gated by glutamate receptors may be a two-step process. Nature (1982) 1.45
For the benefit of all. Hastings Cent Rep (1994) 1.41
Modulation of GABAA receptor activity by alphaxalone. Br J Pharmacol (1987) 1.40
Non-random openings and concentration-dependent lifetimes of glutamate-gated channels in muscle membrane. Nature (1981) 1.39
Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids. Br J Pharmacol (1988) 1.35
Cloning and functional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit. Eur J Pharmacol (1993) 1.34
Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus. Neuropharmacology (2008) 1.32
Antagonism of GABAA receptors by 4-quinolones. J Antimicrob Chemother (1993) 1.25
Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells. Eur J Pharmacol (1988) 1.25
Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol (1998) 1.20
Recent advances in the electrophysiological characterization of 5-HT3 receptors. Trends Pharmacol Sci (1992) 1.19
Complementary regulation of anaesthetic activation of human (alpha6beta3gamma2L) and Drosophila (RDL) GABA receptors by a single amino acid residue. J Physiol (1999) 1.16
Modulation of native and recombinant GABA(A) receptors by endogenous and synthetic neuroactive steroids. Brain Res Brain Res Rev (2001) 1.15
Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Prog Neurobiol (2003) 1.15
Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes. Br J Pharmacol (1996) 1.14
Neuroactive steroids and inhibitory neurotransmission: mechanisms of action and physiological relevance. Neuroscience (2005) 1.14
Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor. J Pharmacol Exp Ther (1997) 1.11
The structure and (local) stability constants of borate esters of mono- and di-saccharides as studied by 11B and 13C NMR spectroscopy. Carbohydr Res (1994) 1.11
Drug-induced modification of ionic conductance at the neuromuscular junction. Annu Rev Pharmacol Toxicol (1983) 1.10
An electrophysiological investigation of the properties of a murine recombinant 5-HT3 receptor stably expressed in HEK 293 cells. Br J Pharmacol (1995) 1.09
The interaction of general anaesthetics and neurosteroids with GABA(A) and glycine receptors. Neurochem Int (1999) 1.09
National Cancer Institute program on nutrition and cancer. Cancer Res (1975) 1.08
The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells. J Neurosci (1990) 1.07
Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor. Proc Natl Acad Sci U S A (1994) 1.04
The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: a voltage clamp study on neuronal cells in culture. Br J Pharmacol (1989) 1.03
Proportion of heritable paraganglioma cases and associated clinical characteristics. Laryngoscope (2001) 1.02
An electrophysiological investigation of the characteristics and function of GABAA receptors on bovine adrenomedullary chromaffin cells. Pflugers Arch (1989) 1.01
The effects of quinolones and NSAIDs upon GABA-evoked currents recorded from rat dorsal root ganglion neurones. J Antimicrob Chemother (1991) 1.01
The interaction of trichloroethanol with murine recombinant 5-HT3 receptors. Br J Pharmacol (1995) 1.01
Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit. Mol Pharmacol (1995) 1.00
Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci Lett (1990) 0.99
The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor. Br J Pharmacol (1998) 0.99
A comparison of the facilitatory actions of 4-aminopyridine methiodide and 4-aminopyridine on neuromuscular transmission. Br J Pharmacol (1979) 0.99
Guide to receptors and channels, 1st edition. Br J Pharmacol (2004) 0.99
Neurosteroid modulation of native and recombinant GABAA receptors. Cell Mol Neurobiol (1996) 0.98
The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. Br J Anaesth (2004) 0.97
Guide to receptors and channels, 2nd edition. Br J Pharmacol (2006) 0.97
General anaesthetic action at transmitter-gated inhibitory amino acid receptors. Trends Pharmacol Sci (1999) 0.97
Steroid modulation of the GABAA receptor complex: electrophysiological studies. Ciba Found Symp (1990) 0.97
Electrophysiology of 5-HT3 receptors in neuronal cell lines. Trends Pharmacol Sci (1989) 0.96
A patch clamp study of the nicotinic acetylcholine receptor of bovine adrenomedullary chromaffin cells in culture. J Physiol (1992) 0.96
Influence of sex-steroid hormones on the regulation of lymphocyte beta 2-adrenoceptors during the menstrual cycle. Br J Clin Pharmacol (1994) 0.95
Cardiac valve replacement with the stabilized glutaraldehyde porcine aortic valve: indications, operative results, and followup. Chest (1975) 0.95
The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors. J Physiol (2000) 0.95
Synthesis, characterization, and relaxivity of two linear Gd(DTPA)-polymer conjugates. Bioconjug Chem (2001) 0.94
An electrophysiological investigation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture. Br J Pharmacol (1993) 0.94
A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors. Br J Pharmacol (2013) 0.94
Molecular determinants of (+)-tubocurarine binding at recombinant 5-hydroxytryptamine3A receptor subunits. Mol Pharmacol (1999) 0.94
A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor. Eur J Pharmacol (1990) 0.94
Pharmacological characterization of the apparent splice variants of the murine 5-HT3 R-A subunit expressed in Xenopus laevis oocytes. Neuropharmacology (1994) 0.94
Modulation of GABAA and glycine receptors by chlormethiazole. Eur J Pharmacol (1992) 0.93
Correlation of neuroactive steroid modulation of [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding and gamma-aminobutyric acidA receptor function. Mol Pharmacol (1994) 0.93
Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells. Br J Pharmacol (1996) 0.93