UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 27149259)

Published in PLoS Genet on May 05, 2016

Authors

Jianqiang Bao1, Kristoffer Vitting-Seerup2,3, Johannes Waage2,3,4,5, Chong Tang1, Ying Ge2,4,5, Bo T Porse2,4,5, Wei Yan1

Author Affiliations

1: Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, United States of America.
2: Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark.
3: The Bioinformatic Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, Copenhagen, Denmark.
4: The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
5: Danish Stem Cell Centre (DanStem), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Articles citing this

Alternative polyadenylation of mRNA precursors. Nat Rev Mol Cell Biol (2016) 0.84

RNA Decay, Evolution, and the Testis. RNA Biol (2016) 0.75

Articles cited by this

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99

TopHat: discovering splice junctions with RNA-Seq. Bioinformatics (2009) 81.13

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol (2010) 75.21

A global double-fluorescent Cre reporter mouse. Genesis (2007) 17.86

HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature (2008) 14.17

Understanding alternative splicing: towards a cellular code. Nat Rev Mol Cell Biol (2005) 13.21

Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science (2008) 11.33

Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell (2009) 10.50

Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc Natl Acad Sci U S A (2002) 10.28

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise. Nat Genet (2004) 6.14

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol Cell Biol (2002) 5.80

Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. Proc Natl Acad Sci U S A (2009) 5.13

Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nat Genet (1995) 5.02

The power of the 3' UTR: translational control and development. Nat Rev Genet (2003) 4.84

Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal. Physiol Rev (1972) 3.74

NMD: a multifaceted response to premature translational termination. Nat Rev Mol Cell Biol (2012) 3.64

Comprehensive polyadenylation site maps in yeast and human reveal pervasive alternative polyadenylation. Cell (2010) 3.42

Developmentally regulated expression of a mouse germ cell nuclear antigen examined from embryonic day 11 to adult in male and female mice. Dev Biol (1994) 3.07

Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol Cell (2005) 2.79

hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Mol Cell Biol (2006) 2.69

Male germ cell gene expression. Recent Prog Horm Res (2002) 2.66

Reprogramming of 3' untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell types. PLoS One (2009) 2.64

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length. Nat Struct Mol Biol (2006) 2.39

Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet (2013) 2.37

Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development (2004) 2.30

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Nat Struct Mol Biol (2007) 2.30

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev (2008) 2.26

The chromatoid body: a germ-cell-specific RNA-processing centre. Nat Rev Mol Cell Biol (2007) 2.15

Upf1 senses 3'UTR length to potentiate mRNA decay. Cell (2010) 2.09

Generation of a germ cell-specific mouse transgenic Cre line, Vasa-Cre. Genesis (2007) 2.08

Global patterns of tissue-specific alternative polyadenylation in Drosophila. Cell Rep (2012) 1.99

Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A (2006) 1.87

Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic mice. Genesis (2008) 1.83

Sohlh1 is essential for spermatogonial differentiation. Dev Biol (2006) 1.74

Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression. Genes Dev (2013) 1.74

Systematic variation in mRNA 3'-processing signals during mouse spermatogenesis. Nucleic Acids Res (2006) 1.56

Post-transcriptional control of gene expression during spermatogenesis. Semin Cell Dev Biol (1998) 1.54

RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD. Mol Cell (2011) 1.50

Regulation of gene expression during spermatogenesis. Semin Cell Dev Biol (1998) 1.44

Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm. Mol Cell (2007) 1.41

Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs. EMBO J (2001) 1.41

SOHLH1 and SOHLH2 coordinate spermatogonial differentiation. Dev Biol (2011) 1.39

Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay. Genome Res (2013) 1.39

Patterns, mechanisms, and functions of translation regulation in mammalian spermatogenic cells. Cytogenet Genome Res (2003) 1.34

Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns. Genome Biol (2012) 1.34

Molecular characterization of the testis specific c-abl mRNA in mouse. EMBO J (1987) 1.31

MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway. J Biol Chem (2012) 1.31

Male germ cells express abundant endogenous siRNAs. Proc Natl Acad Sci U S A (2011) 1.29

Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility. Proc Natl Acad Sci U S A (2007) 1.29

Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs. Nat Struct Mol Biol (2013) 1.26

Regulation of nonsense-mediated mRNA decay. Wiley Interdiscip Rev RNA (2012) 1.24

Temporal control of protein synthesis during spermatogenesis. Int J Androl (2000) 1.21

Alternative splicing in the testes. Curr Opin Genet Dev (2002) 1.16

Regulation and dysregulation of 3'UTR-mediated translational control. Curr Opin Genet Dev (2013) 1.14

Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability. RNA Biol (2012) 1.13

Rules that govern UPF1 binding to mRNA 3' UTRs. Proc Natl Acad Sci U S A (2013) 1.13

Tissue-specific mechanisms of alternative polyadenylation: testis, brain, and beyond. Wiley Interdiscip Rev RNA (2011) 1.09

Crossing the borders: poly(A)-binding proteins working on both sides of the fence. RNA Biol (2010) 1.09

Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells. Biol Reprod (2008) 1.08

Control of messenger RNA fate by RNA-binding proteins: an emphasis on mammalian spermatogenesis. J Androl (2011) 1.05

Generation of Cyp17iCre transgenic mice and their application to conditionally delete estrogen receptor alpha (Esr1) from the ovary and testis. Genesis (2008) 1.04

Incomplete cre-mediated excision leads to phenotypic differences between Stra8-iCre; Mov10l1(lox/lox) and Stra8-iCre; Mov10l1(lox/Δ) mice. Genesis (2013) 1.01

An atlas of chromatoid body components. RNA (2014) 0.95

Expression profiling reveals developmentally regulated lncRNA repertoire in the mouse male germline. Biol Reprod (2013) 0.94

3'UTRs take a long shot in the brain. Bioessays (2013) 0.92

3' UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons. Cell Rep (2014) 0.92

Separate elements in the 3' untranslated region of the mouse protamine 1 mRNA regulate translational repression and activation during murine spermatogenesis. Dev Biol (1997) 0.91

DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic Acids Res (2013) 0.89

The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages. Mol Biol Cell (2011) 0.88

spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data. BMC Bioinformatics (2014) 0.88

STK31(TDRD8) is dynamically regulated throughout mouse spermatogenesis and interacts with MIWI protein. Histochem Cell Biol (2011) 0.85

Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice. Cell Death Differ (2014) 0.82

Expression of MAEL in nuage and non-nuage compartments of rat spermatogenic cells and colocalization with DDX4, DDX25 and MIWI. Histochem Cell Biol (2013) 0.80

Identification of potential regulatory elements in the 5' and 3' UTRs of 12 translationally regulated mRNAs in mammalian spermatids by comparative genomics. J Androl (2011) 0.78

UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. Development (2014) 0.78