Published in Proc Natl Acad Sci U S A on February 12, 2013
Organizing principles of mammalian nonsense-mediated mRNA decay. Annu Rev Genet (2013) 2.55
Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes. Nat Rev Mol Cell Biol (2015) 1.61
Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay. Genome Res (2013) 1.39
Staufen-mediated mRNA decay. Wiley Interdiscip Rev RNA (2013) 1.26
Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs. Nat Struct Mol Biol (2013) 1.26
A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. Genes Dev (2014) 1.09
The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes Dev (2013) 1.07
Nonsense-mediated mRNA decay in humans at a glance. J Cell Sci (2016) 1.01
Mechanism and regulation of the nonsense-mediated decay pathway. Nucleic Acids Res (2016) 0.99
Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story. Annu Rev Genet (2015) 0.98
The dharma of nonsense-mediated mRNA decay in mammalian cells. Mol Cells (2014) 0.95
Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics. Nat Commun (2015) 0.93
NMD: At the crossroads between translation termination and ribosome recycling. Biochimie (2014) 0.90
Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities. Nat Commun (2015) 0.90
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. Mol Cell (2015) 0.89
Nonsense-mediated RNA decay--a switch and dial for regulating gene expression. Bioessays (2015) 0.89
Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit. RNA (2013) 0.88
Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway. Elife (2016) 0.88
Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis. Gene Ther (2014) 0.84
Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila. Genome Res (2015) 0.81
Retroviral strategy to stabilize viral RNA. Curr Opin Microbiol (2014) 0.81
The feedback control of UPF3 is crucial for RNA surveillance in plants. Nucleic Acids Res (2015) 0.78
UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. Development (2014) 0.78
Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay. PLoS Genet (2016) 0.78
Selection for reduced translation costs at the intronic 5' end in fungi. DNA Res (2016) 0.77
Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation. Translation (Austin) (2013) 0.77
Viral Evasion and Manipulation of Host RNA Quality Control Pathways. J Virol (2016) 0.77
Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex. Nucleic Acids Res (2016) 0.77
UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genet (2016) 0.76
A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay. PLoS One (2017) 0.75
The birth of a human-specific neural gene by incomplete duplication and gene fusion. Genome Biol (2017) 0.75
The Arabidopsis NMD Factor UPF3 Is Feedback-Regulated at Multiple Levels and Plays a Role in Plant Response to Salt Stress. Front Plant Sci (2016) 0.75
Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways. RNA (2016) 0.75
ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons. Nat Commun (2016) 0.75
The role of nucleotide composition in premature termination codon recognition. BMC Bioinformatics (2016) 0.75
DNA substrate recognition and processing by the full-length human UPF1 helicase. Nucleic Acids Res (2017) 0.75
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Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev (2006) 5.59
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell (2000) 5.54
Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell (2001) 4.92
Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell (2003) 4.17
Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease. Eur J Hum Genet (2006) 3.80
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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev (1998) 3.71
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell (2008) 3.26
Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cell Mol Life Sci (2009) 2.79
SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Nat Struct Mol Biol (2008) 2.73
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell (2005) 2.71
A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol (2008) 2.61
SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA (2008) 2.54
Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region. PLoS Biol (2008) 2.54
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell (2010) 2.53
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J (2008) 2.52
Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2. Mol Cell (2011) 2.31
Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation. Genes Dev (1994) 2.13
NMD: RNA biology meets human genetic medicine. Biochem J (2010) 2.09
Upf1 senses 3'UTR length to potentiate mRNA decay. Cell (2010) 2.09
UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol Cell (2010) 2.04
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
Disassembly of exon junction complexes by PYM. Cell (2009) 1.69
Introducing sense into nonsense in treatments of human genetic diseases. Trends Genet (2008) 1.69
The pioneer round of translation: features and functions. Cell (2010) 1.66
N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res (2011) 1.55
Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Nat Struct Mol Biol (2007) 1.26
Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. Genes Dev (2009) 1.22
Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev (2013) 1.18
Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors. RNA (2010) 1.00
Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex. Nucleic Acids Res (2010) 0.93
Testing the faux-UTR model for NMD: analysis of Upf1p and Pab1p competition for binding to eRF3/Sup35p. Biochimie (2012) 0.92
Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity. Nucleic Acids Res (2012) 0.92
lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature (2011) 5.42
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev (2007) 4.97
Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell (2003) 4.17
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Cell (2005) 4.02
Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol (2005) 3.99
Regulation of cytoplasmic mRNA decay. Nat Rev Genet (2012) 3.30
Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell (2008) 3.26
Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev (2006) 3.18
The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet (2008) 3.00
The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J (2002) 2.76
Organizing principles of mammalian nonsense-mediated mRNA decay. Annu Rev Genet (2013) 2.55
Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges. Trends Mol Med (2006) 2.39
Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol Cell Biol (2008) 2.25
Staufen1 regulates diverse classes of mammalian transcripts. EMBO J (2007) 2.18
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell (2004) 2.09
UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol Cell (2010) 2.04
CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol (2005) 2.00
SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes Dev (2008) 1.97
A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol (2011) 1.95
The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. Genes Dev (2004) 1.93
eIF4G is required for the pioneer round of translation in mammalian cells. Nat Struct Mol Biol (2004) 1.54
Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Curr Opin Genet Dev (2011) 1.52
Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails. Mol Cell Biol (2006) 1.50
Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon. Proc Natl Acad Sci U S A (2002) 1.33
STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown. Genes Dev (2013) 1.32
Re-capping the message. Trends Biochem Sci (2009) 1.28
Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Nat Struct Mol Biol (2007) 1.26
Staufen-mediated mRNA decay. Wiley Interdiscip Rev RNA (2013) 1.26
Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay. Mol Cell (2008) 1.22
Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. Genes Dev (2009) 1.22
Control of myogenesis by rodent SINE-containing lncRNAs. Genes Dev (2013) 1.21
Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev (2013) 1.18
Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proc Natl Acad Sci U S A (2012) 1.06
Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A (2005) 1.05
mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay. Nat Struct Mol Biol (2013) 1.01
Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay. Nat Struct Mol Biol (2013) 1.00
The dharma of nonsense-mediated mRNA decay in mammalian cells. Mol Cells (2014) 0.95
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. EMBO Rep (2008) 0.95
"Alu"strious long ncRNAs and their role in shortening mRNA half-lives. Cell Cycle (2011) 0.92
Biochemical analysis of long non-coding RNA-containing ribonucleoprotein complexes. Methods (2012) 0.91
Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells. Methods Enzymol (2008) 0.87
Immunopurification and analysis of protein and RNA components of mRNP in mammalian cells. Methods Mol Biol (2004) 0.85
An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA. Trends Cell Biol (2004) 0.80
Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells. Methods Mol Biol (2015) 0.78
RNA turnover in eukaryotes: nucleases, pathways and analysis of mRNA decay. Preface. Methods Enzymol (2008) 0.77
UPF1 learns to relax and unwind. Mol Cell (2011) 0.77
New gene expression pipelines gush lncRNAs. Genome Biol (2013) 0.77
Nonsense-mediated decay: assaying for effects on selenoprotein mRNAs. Methods Enzymol (2002) 0.76
RNA-protein interactions: insight into gene function. Methods (2002) 0.76
Telomeric RNAs as a novel player in telomeric integrity. F1000 Biol Rep (2009) 0.75
RNA turnover in prokaryotes, archaea and organelles. Preface. Methods Enzymol (2008) 0.75
RNA turnover in eukaryotes: analysis of specialized and quality control RNA decay pathways. Preface. Methods Enzymol (2008) 0.75