Published in Nat Struct Mol Biol on December 09, 2007
NMD: a multifaceted response to premature translational termination. Nat Rev Mol Cell Biol (2012) 3.64
The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet (2008) 3.00
Organizing principles of mammalian nonsense-mediated mRNA decay. Annu Rev Genet (2013) 2.55
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell (2010) 2.53
Nonsense-mediated mRNA decay (NMD) mechanisms. Nat Struct Mol Biol (2009) 2.31
Upf1 senses 3'UTR length to potentiate mRNA decay. Cell (2010) 2.09
UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol Cell (2010) 2.04
Translation drives mRNA quality control. Nat Struct Mol Biol (2012) 1.97
SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes Dev (2008) 1.97
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export. Nature (2011) 1.70
Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Curr Opin Genet Dev (2011) 1.52
The regulation of mRNA stability in mammalian cells: 2.0. Gene (2012) 1.46
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. EMBO J (2009) 1.44
Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation. Proc Natl Acad Sci U S A (2015) 1.43
Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay. Genome Res (2013) 1.39
The code within the code: microRNAs target coding regions. Cell Cycle (2010) 1.35
Staufen-mediated mRNA decay. Wiley Interdiscip Rev RNA (2013) 1.26
Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs. Nat Struct Mol Biol (2013) 1.26
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay. PLoS Biol (2009) 1.24
Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. Genes Dev (2009) 1.22
Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Nat Struct Mol Biol (2012) 1.20
Processing bodies are not required for mammalian nonsense-mediated mRNA decay. RNA (2009) 1.20
A UPF3-mediated regulatory switch that maintains RNA surveillance. Nat Struct Mol Biol (2009) 1.16
Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex. Proc Natl Acad Sci U S A (2010) 1.14
Assembly, disassembly and recycling: the dynamics of exon junction complexes. RNA Biol (2011) 1.14
Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation. RNA (2008) 1.13
Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes. Genes Dev (2014) 1.13
The exon junction complex differentially marks spliced junctions. Nat Struct Mol Biol (2010) 1.12
A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. Genes Dev (2014) 1.09
Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways. RNA (2013) 1.07
Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proc Natl Acad Sci U S A (2012) 1.06
Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe. EMBO J (2010) 1.06
The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end. Nat Struct Mol Biol (2012) 1.04
Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains. Nucleic Acids Res (2012) 1.04
Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine. Cell (2016) 1.01
Nonsense-mediated mRNA decay in humans at a glance. J Cell Sci (2016) 1.01
mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay. Nat Struct Mol Biol (2013) 1.01
CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter. Cold Spring Harb Symp Quant Biol (2011) 1.00
Mechanism and regulation of the nonsense-mediated decay pathway. Nucleic Acids Res (2016) 0.99
An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev (2013) 0.99
eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol (2013) 0.99
The exon junction complex as a node of post-transcriptional networks. Nat Rev Mol Cell Biol (2015) 0.99
Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability. Mol Psychiatry (2011) 0.99
The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1. J Virol (2012) 0.99
Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story. Annu Rev Genet (2015) 0.98
Structural bioinformatics of the human spliceosomal proteome. Nucleic Acids Res (2012) 0.96
Insights into the activation of the helicase Prp43 by biochemical studies and structural mass spectrometry. Nucleic Acids Res (2013) 0.96
Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. RNA (2011) 0.96
Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. J Biol Chem (2009) 0.96
Gene expression networks: competing mRNA decay pathways in mammalian cells. Biochem Soc Trans (2009) 0.96
Perispeckles are major assembly sites for the exon junction core complex. Mol Biol Cell (2012) 0.95
The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. Nat Struct Mol Biol (2012) 0.95
Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics. Nat Commun (2015) 0.93
The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation. Mol Biol Cell (2012) 0.92
Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity. Nucleic Acids Res (2012) 0.92
NMD: At the crossroads between translation termination and ribosome recycling. Biochimie (2014) 0.90
Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities. Nat Commun (2015) 0.90
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. Mol Cell (2015) 0.89
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic Acids Res (2013) 0.89
Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6. Nucleic Acids Res (2014) 0.89
Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit. RNA (2013) 0.88
A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. Nucleic Acids Res (2014) 0.88
Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway. Elife (2016) 0.88
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. Nucleic Acids Res (2013) 0.86
Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. Nucleic Acids Res (2014) 0.85
Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation. RNA (2011) 0.85
Emerging roles for ribonucleoprotein modification and remodeling in controlling RNA fate. Trends Cell Biol (2013) 0.85
The Ighmbp2 helicase structure reveals the molecular basis for disease-causing mutations in DMSA1. Nucleic Acids Res (2012) 0.84
Full UPF3B function is critical for neuronal differentiation of neural stem cells. Mol Brain (2015) 0.84
Nonsense-mediated mRNA decay and development: shoot the messenger to survive? Biochem Soc Trans (2010) 0.83
Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2. Nucleic Acids Res (2013) 0.83
A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation. Nucleic Acids Res (2015) 0.83
The rules and impact of nonsense-mediated mRNA decay in human cancers. Nat Genet (2016) 0.83
Ribosome-based quality control of mRNA and nascent peptides. Wiley Interdiscip Rev RNA (2016) 0.82
Intra- and intermolecular regulatory interactions in Upf1, the RNA helicase central to nonsense-mediated mRNA decay in yeast. Mol Cell Biol (2013) 0.82
A critical role of RBM8a in proliferation and differentiation of embryonic neural progenitors. Neural Dev (2015) 0.82
MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1. PLoS One (2013) 0.81
Dual function of UPF3B in early and late translation termination. EMBO J (2017) 0.81
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. Nucleic Acids Res (2013) 0.79
Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals. EMBO Rep (2014) 0.79
Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID). PLoS One (2016) 0.78
Molecular mechanics of RNA translocases. Methods Enzymol (2012) 0.78
UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. Development (2014) 0.78
Viral Evasion and Manipulation of Host RNA Quality Control Pathways. J Virol (2016) 0.77
A highly conserved region essential for NMD in the Upf2 N-terminal domain. J Mol Biol (2014) 0.77
Multiple transcripts from a 3'-UTR reporter vary in sensitivity to nonsense-mediated mRNA decay in Saccharomyces cerevisiae. PLoS One (2013) 0.77
HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA. Biomolecules (2015) 0.77
Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex. Nucleic Acids Res (2016) 0.77
Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation. Translation (Austin) (2013) 0.77
UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genet (2016) 0.76
The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation. Nat Commun (2016) 0.76
Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. Mol Cell Biol (2014) 0.76
Intranuclear binding in space and time of exon junction complex and NXF1 to premRNPs/mRNPs in vivo. J Cell Biol (2015) 0.76
Harnessing short poly(A)-binding protein-interacting peptides for the suppression of nonsense-mediated mRNA decay. Sci Rep (2016) 0.75
RNA Decay, Evolution, and the Testis. RNA Biol (2016) 0.75
Multifunctional RNA processing protein SRm160 induces apoptosis and regulates eye and genital development in Drosophila. Genetics (2014) 0.75
Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm. Mol Med Rep (2016) 0.75
RNA Exosome Complex Regulates Stability of the Hepatitis B Virus X-mRNA Transcript in a Non-stop-mediated (NSD) RNA Quality Control Mechanism. J Biol Chem (2016) 0.75
Nonsense-mediated decay regulates key components of homologous recombination. Nucleic Acids Res (2016) 0.75
Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science (2006) 3.60
Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. Genes Dev (2004) 3.13
The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. Nat Struct Mol Biol (2005) 2.40
Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2. Mol Cell (2011) 2.31
5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly. Genes Dev (2002) 1.98
MatrixDB, a database focused on extracellular protein-protein and protein-carbohydrate interactions. Bioinformatics (2009) 1.96
MatrixDB, the extracellular matrix interaction database. Nucleic Acids Res (2010) 1.79
DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. Proc Natl Acad Sci U S A (2003) 1.44
CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex. Nat Struct Mol Biol (2012) 1.40
Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. J Biol Chem (2004) 1.34
A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein. EMBO Rep (2006) 1.33
The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction. EMBO Rep (2008) 1.31
Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Res (2007) 1.28
Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance. Proc Natl Acad Sci U S A (2010) 1.25
Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Mol Cell Biol (2011) 1.24
Mechanism of ATP turnover inhibition in the EJC. RNA (2008) 1.21
Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Nat Struct Mol Biol (2012) 1.20
RNA channelling by the eukaryotic exosome. EMBO Rep (2010) 1.16
The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly. J Cell Sci (2007) 1.16
A UPF3-mediated regulatory switch that maintains RNA surveillance. Nat Struct Mol Biol (2009) 1.16
Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization. BMC Biol (2005) 1.15
Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex. Proc Natl Acad Sci U S A (2010) 1.14
The exon junction complex differentially marks spliced junctions. Nat Struct Mol Biol (2010) 1.12
Substrate affinity and substrate specificity of proteasomes with RNase activity. Mol Biol Rep (2003) 1.06
Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains. Nucleic Acids Res (2012) 1.04
The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1. J Virol (2012) 0.99
Matricryptins derived from collagens and proteoglycans. Front Biosci (Landmark Ed) (2011) 0.98
Perispeckles are major assembly sites for the exon junction core complex. Mol Biol Cell (2012) 0.95
The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. Nat Struct Mol Biol (2012) 0.95
EJC core component MLN51 interacts with eIF3 and activates translation. Proc Natl Acad Sci U S A (2013) 0.94
Transcriptome-wide modulation of splicing by the exon junction complex. Genome Biol (2014) 0.94
Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells. Biochem J (2010) 0.94
Four KH domains of the C. elegans Bicaudal-C ortholog GLD-3 form a globular structural platform. RNA (2010) 0.88
Transcriptome-wide identification of RNA binding sites by CLIP-seq. Methods (2013) 0.88
Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain. Proc Natl Acad Sci U S A (2013) 0.85
Biochemical characterization of the RNA helicase UPF1 involved in nonsense-mediated mRNA decay. Methods Enzymol (2012) 0.82
Recombinant protein quality evaluation: proposal for a minimal information standard. Stand Genomic Sci (2011) 0.82
Bacterial expression, purification and preliminary X-ray crystallographic characterization of the invertase inhibitor Nt-CIF from tobacco. Acta Crystallogr D Biol Crystallogr (2003) 0.81
Expression of GFRalpha1 receptor splicing variants with different biochemical properties is modulated during kidney development. Cell Signal (2004) 0.77
Substrate recognition by the bacterial type II secretion system: more than a simple interaction. Mol Microbiol (2014) 0.77
CLIP-seq to discover transcriptome-wide imprinting of RNA binding proteins in living cells. Methods Mol Biol (2015) 0.75