MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy.

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Published in PLoS One on May 19, 2016

Authors

Anna Polak1, Przemysław Kiliszek1, Tomasz Sewastianik1, Maciej Szydłowski1, Ewa Jabłońska1, Emilia Białopiotrowicz1, Patryk Górniak1,2, Sergiusz Markowicz3, Eliza Nowak3, Monika A Grygorowicz3, Monika Prochorec-Sobieszek2, Dominika Nowis4,5, Jakub Gołąb6, Sebastian Giebel7, Ewa Lech-Marańda8,9, Krzysztof Warzocha8, Przemysław Juszczyński1

Author Affiliations

1: Dept. of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
2: Dept. of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
3: Dept. of Immunology, Maria Sklodowska-Curie Memorial Cancer Center-Institute of Oncology, Warsaw, Poland.
4: Genomic Medicine, Dept. of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
5: Laboratory of Experimental Medicine, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
6: Dept. of Immunology, Center of Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
7: Dept. of Bone Marrow Transplantation and Hematology-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland.
8: Dept. of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
9: Dept. of Hematology and Transfusion Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland.

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