Published in Cell on October 13, 2000
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol (2008) 5.19
MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer (2013) 3.60
Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol (2002) 2.61
The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev (2010) 2.27
Role of p14(ARF) in replicative and induced senescence of human fibroblasts. Mol Cell Biol (2001) 2.27
Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc Natl Acad Sci U S A (2001) 2.10
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J (2002) 1.96
TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells. Proc Natl Acad Sci U S A (2011) 1.94
Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 1.89
Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res (2009) 1.87
Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol (2004) 1.85
Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival. Pigment Cell Melanoma Res (2007) 1.80
Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J (2001) 1.69
Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion. Mol Cell Biol (2008) 1.53
The MDM2-p53 pathway revisited. J Biomed Res (2013) 1.52
TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. J Clin Invest (2009) 1.50
Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Mol Cell Biol (2005) 1.50
p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J (2003) 1.44
Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling. Mol Cell Biol (2001) 1.37
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. Genes Dev (2002) 1.36
The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck. J Med Genet (2005) 1.34
Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Mol Cell Biol (2003) 1.32
Integrins regulate the apoptotic response to DNA damage through modulation of p53. Proc Natl Acad Sci U S A (2002) 1.29
Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression. Mol Cell Biol (2004) 1.19
Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol (2001) 1.19
c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation. Mol Cell Biol (2004) 1.13
Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function. Neoplasia (2009) 1.13
Nucleolar adaptation in human cancer. Cancer Invest (2005) 1.13
Functions of MDMX in the modulation of the p53-response. J Biomed Biotechnol (2011) 1.12
Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2. PLoS One (2012) 1.09
ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation. Mol Cell Biol (2009) 1.09
Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck. Mol Carcinog (2011) 1.07
MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism. BMC Cancer (2008) 1.06
Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Cancer Res (2008) 1.02
Regulation of MDMX expression by mitogenic signaling. Mol Cell Biol (2008) 1.01
A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function. Mol Cell Biol (2007) 1.00
An update on molecular genetics of gastrointestinal stromal tumours. J Clin Pathol (2006) 1.00
Ets1 induces dysplastic changes when expressed in terminally-differentiating squamous epidermal cells. PLoS One (2009) 1.00
Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J Biol Chem (2010) 0.99
Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53. Mol Cell Biol (2004) 0.97
Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5. J Biol Chem (2013) 0.97
SHP2E76K mutant promotes lung tumorigenesis in transgenic mice. Carcinogenesis (2014) 0.97
Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage. Mol Cell Biol (2006) 0.95
Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth. Cancer Res (2011) 0.94
Mdm2 links genotoxic stress and metabolism to p53. Protein Cell (2011) 0.92
Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis. Proc Natl Acad Sci U S A (2002) 0.91
MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change. J Biol Chem (2010) 0.90
The Many Faces of MDM2 Binding Partners. Genes Cancer (2012) 0.90
MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress. Mol Cell Biol (2012) 0.89
Transcription factor NFAT1 activates the mdm2 oncogene independent of p53. J Biol Chem (2012) 0.88
MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia. Blood (2015) 0.88
Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer. Oncol Rep (2013) 0.88
Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell Death Differ (2012) 0.88
Identification of functional DNA variants in the constitutive promoter region of MDM2. Hum Genomics (2012) 0.87
Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts. J Biol Chem (2008) 0.87
Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis. Nucleic Acids Res (2008) 0.86
Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway. Cell Signal (2009) 0.86
Regions and activities of simian virus 40 T antigen that cooperate with an activated ras oncogene in transforming primary rat embryo fibroblasts. J Virol (2002) 0.86
Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytes. Am J Pathol (2003) 0.86
Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation. J Biol Chem (2012) 0.86
Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytes. J Biol Chem (2009) 0.85
MDM2: a novel mineralocorticoid-responsive gene involved in aldosterone-induced human vascular structural remodeling. Am J Pathol (2006) 0.85
Tumor suppression in skin and other tissues via cross-talk between vitamin D- and p53-signaling. Front Physiol (2014) 0.84
P53 is necessary for the apoptotic response mediated by a transient increase of Ras activity. Mol Cell Biol (2002) 0.83
A 40-bp insertion/deletion polymorphism of Murine Double Minute2 (MDM2) increased the risk of breast cancer in Zahedan, Southeast Iran. Iran Biomed J (2014) 0.83
Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation. J Biol Chem (2014) 0.82
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. Br J Cancer (2008) 0.82
MDM2 SNP309 polymorphism is associated with colorectal cancer risk. Sci Rep (2014) 0.81
Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa. Br J Cancer (2010) 0.81
Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras. Exp Cell Res (2011) 0.80
TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis. Cancer Res (2015) 0.80
microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. Oncotarget (2016) 0.79
Vitamin D directly regulates Mdm2 gene expression in osteoblasts. Biochem Biophys Res Commun (2012) 0.79
Therapeutic considerations for Mdm2: not just a one trick pony. Expert Opin Drug Discov (2008) 0.79
Significance of MDM2 and P14 ARF polymorphisms in susceptibility to differentiated thyroid carcinoma. Surgery (2012) 0.78
Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neck. Eur J Cancer (2013) 0.77
Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome. PLoS One (2016) 0.75
NORE1A Regulates MDM2 Via β-TrCP. Cancers (Basel) (2016) 0.75
MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy. PLoS One (2016) 0.75
Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention. Med Mol Morphol (2007) 0.75
Modulation of the p53 family network by RNA-binding proteins. Transl Cancer Res (2016) 0.75
Association of MDM2 expression with shorter progression-free survival and overall survival in patients with advanced pancreatic cancer treated with gemcitabine-based chemotherapy. PLoS One (2017) 0.75
Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (1999) 20.34
The GTPase superfamily: conserved structure and molecular mechanism. Nature (1991) 19.64
The GTPase superfamily: a conserved switch for diverse cell functions. Nature (1990) 11.71
Proteins regulating Ras and its relatives. Nature (1993) 9.87
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature (1991) 9.21
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell (1984) 8.32
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science (1997) 8.17
mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01
A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science (1987) 7.69
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature (1985) 6.86
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol (1988) 6.44
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell (1990) 6.37
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science (1994) 6.07
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (1996) 5.97
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature (1990) 5.57
Wild-type p53 can inhibit oncogene-mediated focus formation. Proc Natl Acad Sci U S A (1989) 5.40
An essential role for Rac in Ras transformation. Nature (1995) 5.34
Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev (1998) 5.14
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell (1992) 5.09
Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells. J Virol (1980) 4.88
PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell (1990) 4.85
Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science (1993) 4.76
Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science (1988) 4.58
Inhibition by cAMP of Ras-dependent activation of Raf. Science (1993) 4.50
Pneumocystis carinii infection: evidence for high prevalence in normal and immunosuppressed children. Pediatrics (1978) 4.44
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol (1997) 4.36
Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene (1998) 4.31
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A (2000) 3.74
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med (1997) 3.64
The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. Nature (1995) 3.61
A role for Rho in Ras transformation. Proc Natl Acad Sci U S A (1995) 3.59
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature (1999) 3.50
Wild-type p53 can down-modulate the activity of various promoters. Proc Natl Acad Sci U S A (1991) 3.45
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev (1995) 3.40
Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53. Mol Cell Biol (1983) 3.39
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol Cell Biol (1992) 3.37
Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. J Biol Chem (2000) 3.28
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature (2001) 3.24
Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol (1998) 3.23
Nomenclature for factors of the HLA system, 2010. Tissue Antigens (2010) 3.22
p53 in growth control and neoplasia. Biochim Biophys Acta (1996) 3.19
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J (1985) 3.18
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol Cell Biol (1993) 3.13
p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors. Mol Cell Biol (1985) 3.13
Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res (1995) 3.11
Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene (1993) 3.08
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet (1996) 3.08
Signal transduction. How receptors turn Ras on. Nature (1993) 3.01
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J (1995) 2.99
Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proc Natl Acad Sci U S A (1988) 2.99
A single gene and a pseudogene for the cellular tumour antigen p53. Nature (1984) 2.98
Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg. Neuron (1996) 2.97
Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling. Mol Cell (2000) 2.95
Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. Nature (1986) 2.94
Analysis of the gene coding for the murine cellular tumour antigen p53. EMBO J (1984) 2.94
Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J Biol Chem (2001) 2.93
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med (1998) 2.91
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev (1994) 2.88
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.87
Canadian medicare: view from Utopia. CMAJ (1991) 2.84
Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N Engl J Med (1994) 2.81
p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death Differ (2009) 2.80
Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Res (2001) 2.78
Differential affinities of simian virus 40 large tumor antigen for DNA. Proc Natl Acad Sci U S A (1980) 2.75
Overproduction of p53 antigen makes established cells highly tumorigenic. Nature (1985) 2.72
Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. Cancer Res (1992) 2.72
Meth A fibrosarcoma cells express two transforming mutant p53 species. Oncogene (1988) 2.71
Whither health care in South Africa? BMJ (1993) 2.68
Non-visualization of the cavum septi pellucidi is not synonymous with agenesis of the corpus callosum. Ultrasound Obstet Gynecol (2012) 2.65
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J (1999) 2.64
Brefeldin A: the advantage of being uncompetitive. Cell (1999) 2.63
Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev (2000) 2.62
A model for the tertiary structure of p21, the product of the ras oncogene. Science (1985) 2.61
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett (2001) 2.57
Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev (2001) 2.56
Localization of gene for human p53 tumour antigen to band 17p13. Nature (1986) 2.56
Molecular analysis of a human interferon-inducible gene family. Eur J Biochem (1991) 2.46
Interventions for promoting the initiation of breastfeeding. Cochrane Database Syst Rev (2005) 2.45
Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science (1994) 2.44
Genetic analysis of mammalian GAP expressed in yeast. Cell (1989) 2.44
Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol Cell Biol (1997) 2.44
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene (1999) 2.43
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Mol Cell Biol (1991) 2.40
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans (2000) 2.40
RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J (1993) 2.38
Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell (1992) 2.32
p53-mediated cell death: relationship to cell cycle control. Mol Cell Biol (1993) 2.27
Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. Cell (1991) 2.26
TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma. Cell Death Differ (2005) 2.25
Strength in study: an informal history of the college of family physicians. Can Fam Physician (1979) 2.25
Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol (1990) 2.25
Insulin stimulation of gene expression mediated by p21ras activation. EMBO J (1991) 2.23
A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res (1995) 2.23