Autophagy regulation by p53.

Autophagy in malignant transformation and cancer progression. EMBO J (2015) 2.67

FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature (2013) 2.62

Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32

Metabolic regulation by p53 family members. Cell Metab (2013) 2.00

Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ (2014) 2.00

Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov (2014) 1.97

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev (2013) 1.88

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci U S A (2010) 1.77

BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Blood (2011) 1.61

Autophagy and cancer. Exp Mol Med (2012) 1.57

p53, ROS and senescence in the control of aging. Aging (Albany NY) (2010) 1.56

Autophagy as a therapeutic target in cardiovascular disease. J Mol Cell Cardiol (2011) 1.48

p53/HMGB1 complexes regulate autophagy and apoptosis. Cancer Res (2012) 1.41

TP53 and MTOR crosstalk to regulate cellular senescence. Aging (Albany NY) (2010) 1.32

Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle (2012) 1.25

Cerium dioxide nanoparticles induce apoptosis and autophagy in human peripheral blood monocytes. ACS Nano (2012) 1.19

MicroRNAs in apoptosis, autophagy and necroptosis. Oncotarget (2015) 1.17

Review: Oxygen and trophoblast biology--a source of controversy. Placenta (2011) 1.16

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy. Trends Cell Biol (2015) 1.16

Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol (2011) 1.13

Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle. J Physiol (2013) 1.12

Trial watch: DNA vaccines for cancer therapy. Oncoimmunology (2013) 1.11

Hormesis, cell death and aging. Aging (Albany NY) (2011) 1.11

Negative regulation of autophagy. Cell Death Differ (2010) 1.07

Increased autophagy in placentas of intrauterine growth-restricted pregnancies. PLoS One (2012) 1.07

p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO J (2011) 1.07

Emerging roles of E3 ubiquitin ligases in autophagy. Trends Biochem Sci (2013) 1.07

7SL RNA represses p53 translation by competing with HuR. Nucleic Acids Res (2014) 1.06

Tumor suppressor p53 and its mutants in cancer metabolism. Cancer Lett (2013) 1.04

The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence. Int J Mol Sci (2013) 1.04

Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03

Regulation of autophagy by nucleoporin Tpr. Sci Rep (2012) 1.02

XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling. EMBO J (2013) 1.02

Regulation of autophagy by kinases. Cancers (Basel) (2011) 1.02

Functions of BCL-X L at the Interface between Cell Death and Metabolism. Int J Cell Biol (2013) 1.02

The complex interplay between autophagy and NF-κB signaling pathways in cancer cells. Am J Cancer Res (2011) 1.01

Deacetylation of p53 induces autophagy by suppressing Bmf expression. J Cell Biol (2013) 1.01

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes. Proc Natl Acad Sci U S A (2014) 1.00

TP53 status and response to treatment in breast cancers. J Biomed Biotechnol (2011) 0.99

DRAM-1 encodes multiple isoforms that regulate autophagy. Autophagy (2012) 0.99

Regulation of the autophagic bcl-2/beclin 1 interaction. Cells (2012) 0.98

Regulation of autophagy by glucose in Mammalian cells. Cells (2012) 0.97

p53 and mitochondrial function in neurons. Biochim Biophys Acta (2014) 0.97

Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells. PLoS One (2012) 0.97

The Regulation of Aging and Longevity: A New and Complex Role of p53. Genes Cancer (2011) 0.97

Caught in the cross fire: p53 in inflammation. Carcinogenesis (2014) 0.95

Human apolipoprotein L1 (ApoL1) in cancer and chronic kidney disease. FEBS Lett (2012) 0.95

Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. PLoS Genet (2013) 0.94

Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure. Cell Cycle (2011) 0.94

Neem oil limonoids induces p53-independent apoptosis and autophagy. Carcinogenesis (2012) 0.94

Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. Breast Cancer Res (2013) 0.93

The p53 control of apoptosis and proliferation: lessons from Drosophila. Apoptosis (2014) 0.93

IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PLoS One (2011) 0.92

Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille's heel to be exploited for the therapy of MYCN-amplified neuroblastoma. Front Oncol (2012) 0.91

Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. Cell Cycle (2012) 0.90

Survival by self-destruction: a role for autophagy in the placenta? Placenta (2012) 0.90

p53 is necessary for the adaptive changes in cellular milieu subsequent to an acute bout of endurance exercise. Am J Physiol Cell Physiol (2013) 0.90

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. Drug Des Devel Ther (2015) 0.90

ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells. Cell Death Dis (2014) 0.90

The interplay between DNA repair and autophagy in cancer therapy. Cancer Biol Ther (2015) 0.89

Tumor suppressor p53 and its gain-of-function mutants in cancer. Acta Biochim Biophys Sin (Shanghai) (2013) 0.89

The family that eats together stays together: new p53 family transcriptional targets in autophagy. Genes Dev (2013) 0.89

Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis. Oncotarget (2015) 0.88

p53 as guardian of the mitochondrial genome. FEBS Lett (2016) 0.87

Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment. Cell Cycle (2013) 0.87

Detection of WIPI1 mRNA as an indicator of autophagosome formation. Autophagy (2013) 0.87

Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition. Autophagy (2012) 0.87

Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells. PLoS One (2014) 0.86

Wip1 phosphatase: between p53 and MAPK kinases pathways. Oncotarget (2016) 0.86

Understanding the non-canonical pathways involved in p53-mediated tumor suppression. Carcinogenesis (2013) 0.86

Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells. Aging (Albany NY) (2010) 0.86

Trial Watch: DNA vaccines for cancer therapy. Oncoimmunology (2014) 0.86

A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. Autophagy (2014) 0.85

A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma. PLoS One (2013) 0.85

Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? Carcinogenesis (2015) 0.85

Clinical utility of anti-p53 auto-antibody: systematic review and focus on colorectal cancer. World J Gastroenterol (2013) 0.84

Autophagy, a process within reperfusion injury: an update. Int J Clin Exp Pathol (2014) 0.84

PTEN deficiency and mutant p53 confer glucose-addiction to thyroid cancer cells: impact of glucose depletion on cell proliferation, cell survival, autophagy and cell migration. Genes Cancer (2014) 0.84

Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases. Mol Neurobiol (2014) 0.81

Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. PLoS Genet (2014) 0.81

Unbreak my heart: targeting mitochondrial autophagy in diabetic cardiomyopathy. Antioxid Redox Signal (2015) 0.81

Inhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic death. PLoS One (2014) 0.81

Tumor bioenergetics: an emerging avenue for cancer metabolism targeted therapy. BMB Rep (2014) 0.81

Epigenetic control of autophagy by microRNAs in ovarian cancer. Biomed Res Int (2014) 0.81

The role of p21 in regulating mammalian regeneration. Stem Cell Res Ther (2011) 0.81

Transcriptional Regulation by Nuclear Corepressors and PGC-1α: Implications for Mitochondrial Quality Control and Insulin Sensitivity. PPAR Res (2012) 0.80

The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core. PLoS One (2015) 0.80

Volatile Oil of Acori Graminei Rhizoma-Induced Apoptosis and Autophagy are dependent on p53 Status in Human Glioma Cells. Sci Rep (2016) 0.80

Tetraploidization or autophagy: The ultimate fate of senescent human endometrial stem cells under ATM or p53 inhibition. Cell Cycle (2016) 0.80

The fine tuning of metabolism, autophagy and differentiation during in vitro myogenesis. Cell Death Dis (2016) 0.80

Involvement of autophagy in cardiac remodeling in transgenic mice with cardiac specific over-expression of human programmed cell death 5. PLoS One (2012) 0.79

Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin. Biomed Res Int (2015) 0.79

MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation. PLoS One (2015) 0.79

Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy. Part Fibre Toxicol (2016) 0.79

New small molecules targeting apoptosis and cell viability in osteosarcoma. PLoS One (2015) 0.79

The molecular mechanisms between autophagy and apoptosis: potential role in central nervous system disorders. Cell Mol Neurobiol (2014) 0.79

GADD45A inhibits autophagy by regulating the interaction between BECN1 and PIK3C3. Autophagy (2015) 0.78

MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation. Autophagy (2015) 0.78

Emerging roles of p53 and other tumour-suppressor genes in immune regulation. Nat Rev Immunol (2016) 0.78

Autophagy inhibition enhances apoptosis induced by dioscin in huh7 cells. Evid Based Complement Alternat Med (2012) 0.78

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47

The hallmarks of aging. Cell (2013) 14.29

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90

The pathophysiology of mitochondrial cell death. Science (2004) 13.87

Mitochondrial membrane permeabilization in cell death. Physiol Rev (2007) 12.72

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72

Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54

Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27

Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73

Immunological aspects of cancer chemotherapy. Nat Rev Immunol (2008) 6.61

Immunogenic cell death in cancer therapy. Annu Rev Immunol (2012) 6.59

Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol (2006) 6.13

Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov (2006) 5.99

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

Autophagy and aging. Cell (2011) 5.96

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science (2011) 5.62

Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23

Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00

Cell death by mitotic catastrophe: a molecular definition. Oncogene (2004) 4.75

Cell death by necrosis: towards a molecular definition. Trends Biochem Sci (2006) 4.67

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60

Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy (2008) 4.42

An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35

Immunogenic and tolerogenic cell death. Nat Rev Immunol (2009) 4.34

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med (2005) 4.32

Targeting mitochondria for cancer therapy. Nat Rev Drug Discov (2010) 4.07

The anticancer immune response: indispensable for therapeutic success? J Clin Invest (2008) 4.01

The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Sci (2005) 3.93

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science (2011) 3.74

Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity (2013) 3.73

Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med (2005) 3.64

The secret ally: immunostimulation by anticancer drugs. Nat Rev Drug Discov (2012) 3.60

Decoding cell death signals in inflammation and immunity. Cell (2010) 3.41

Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat Rev Clin Oncol (2011) 3.41

Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol (2011) 3.40

Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity (2013) 3.26

Does autophagy contribute to cell death? Autophagy (2005) 3.21

A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med (2006) 3.21

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle (2006) 3.21

AIF deficiency compromises oxidative phosphorylation. EMBO J (2004) 3.19

BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 3.03

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev (2007) 2.96

Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle (2009) 2.72

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72

Platelet formation is the consequence of caspase activation within megakaryocytes. Blood (2002) 2.62

Necroptosis: a specialized pathway of programmed necrosis. Cell (2008) 2.61

Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med (2003) 2.56

Can autophagy promote longevity? Nat Cell Biol (2010) 2.55

Cell death assays for drug discovery. Nat Rev Drug Discov (2011) 2.51

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol (2002) 2.47

The IKK complex contributes to the induction of autophagy. EMBO J (2009) 2.41

Fatty acids trigger mitochondrion-dependent necrosis. Cell Cycle (2010) 2.37

Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol (2003) 2.37

Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36

An AIF orthologue regulates apoptosis in yeast. J Cell Biol (2004) 2.33

Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32

Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32

Immunogenic tumor cell death for optimal anticancer therapy: the calreticulin exposure pathway. Clin Cancer Res (2010) 2.29

Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol (2012) 2.28

miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Res (2010) 2.24

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23

Viral control of mitochondrial apoptosis. PLoS Pathog (2008) 2.21