Published in Invest New Drugs on May 25, 2016
Metformin and reduced risk of cancer in diabetic patients. BMJ (2005) 13.04
Nile red: a selective fluorescent stain for intracellular lipid droplets. J Cell Biol (1985) 8.03
AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol (2007) 3.72
Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology (2001) 3.38
The preparation of, and studies on, free cell suspensions from mouse pancreatic islets. Diabetologia (1974) 2.69
Mechanisms of beta-cell death in type 2 diabetes. Diabetes (2005) 2.50
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci (2004) 1.89
The regulation of AMP-activated protein kinase by H(2)O(2). Biochem Biophys Res Commun (2001) 1.84
NF-kappa B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Mol Cell Biol (2005) 1.43
AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J Mol Endocrinol (2003) 1.33
AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. Diabetologia (2003) 1.30
Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo. J Endocrinol (2005) 1.08
The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells. Diabetologia (2008) 1.08
Beta cell death and protection. Ann N Y Acad Sci (2003) 1.07
AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells. Diabetologia (2010) 1.00
Role of AMPK in pancreatic beta cell function. Mol Cell Endocrinol (2012) 1.00
On-line monitoring of apoptosis in insulin-secreting cells. Diabetes (2003) 0.99
Diabetes, pancreatic cancer, and metformin therapy. Front Physiol (2014) 0.92
Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells. Neurosci Lett (2010) 0.89
Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery. Diabetes (1996) 0.86
The novel imidazoline compound BL11282 potentiates glucose-induced insulin secretion in pancreatic beta-cells in the absence of modulation of K(ATP) channel activity. Diabetes (2001) 0.86
Two generations of insulinotropic imidazoline compounds. Diabetes (2002) 0.85
Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line. J Endocrinol (2007) 0.84
Differential protein expression in pancreatic islets after treatment with an imidazoline compound. Cell Mol Life Sci (2007) 0.82
Activation of AMP-activated protein kinase mediates acute and severe hypoxic injury to pancreatic beta cells. Biochem Biophys Res Commun (2009) 0.80
Effects of imidazoline derivative RX871024 on insulin, glucagon, and somatostatin secretion from isolated perfused rat pancreas. Biochem Biophys Res Commun (1998) 0.80
On the formation and nature of the imidazoline I2 binding site on human monoamine oxidase-B. Pharmacol Res (2010) 0.80
Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cells. Biochem Biophys Res Commun (2005) 0.78
RX871024 induces Ca2+ mobilization from thapsigargin-sensitive stores in mouse pancreatic beta-cells. Diabetes (1998) 0.78
Metformin can activate imidazoline I-2 receptors to lower plasma glucose in type 1-like diabetic rats. Horm Metab Res (2010) 0.78
RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines. Biochem Biophys Res Commun (2006) 0.77
The imidazoline I2-site ligands BU 224 and 2-BFI inhibit MAO-A and MAO-B activities, hydrogen peroxide production, and lipolysis in rodent and human adipocytes. Eur J Pharmacol (2006) 0.77
Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. Diabetes (2001) 0.77
The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase. Cell Mol Life Sci (2008) 0.77
Islet cell tumours. Adv Exp Med Biol (2010) 0.76