Published in Nat Cell Biol on May 27, 2016
Ubiquitin-Dependent Regulation of Stem Cell Biology. Trends Cell Biol (2017) 0.81
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Cell Rep (2016) 0.80
Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination. J Mol Biol (2016) 0.80
The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97. Front Mol Biosci (2017) 0.79
Ever HRD a ubiquitin-gated channel? Cell Res (2016) 0.75
Revealing a Novel Otubain-Like Enzyme from Leishmania infantum with Deubiquitinating Activity toward K48-Linked Substrate. Front Chem (2017) 0.75
Septins: Regulators of Protein Stability. Front Cell Dev Biol (2016) 0.75
Mechanism of catalysis, E2 recognition, and autoinhibition for the IpaH family of bacterial E3 ubiquitin ligases. Proc Natl Acad Sci U S A (2017) 0.75
A high throughput mutagenic analysis of yeast sumo structure and function. PLoS Genet (2017) 0.75
Guard the guardian: A CRL4 ligase stands watch over histone production. Nucleus (2017) 0.75
USP9X regulates centrosome duplication and promotes breast carcinogenesis. Nat Commun (2017) 0.75
Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25. Sci Rep (2017) 0.75
Beyond Mitophagy: The Diversity and Complexity of Parkin Function. Circ Res (2017) 0.75
Determination of the pKa of the N-terminal amino group of ubiquitin by NMR. Sci Rep (2017) 0.75
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells. Cell Commun Signal (2017) 0.75
ρ⁰ Cells Feature De-Ubiquitination of SLC Transporters and Increased Levels and Fluxes of Amino Acids. Int J Mol Sci (2017) 0.75
Controlling DNA-End Resection: An Emerging Task for Ubiquitin and SUMO. Front Genet (2016) 0.75
The TRIMendous Role of TRIMs in Virus-Host Interactions. Vaccines (Basel) (2017) 0.75
Meddling with Fate: The Proteasomal Deubiquitinating Enzymes. J Mol Biol (2017) 0.75
Enzyme-substrate relationships in the ubiquitin system: approaches for identifying substrates of ubiquitin ligases. Cell Mol Life Sci (2017) 0.75
Site-specific incorporation of phosphotyrosine using an expanded genetic code. Nat Chem Biol (2017) 0.75
Legionella and Coxiella effectors: strength in diversity and activity. Nat Rev Microbiol (2017) 0.75
Targeted Protein Degradation: from Chemical Biology to Drug Discovery. Cell Chem Biol (2017) 0.75
Determining Atomistic SAXS Models of Tri-Ubiquitin Chains from Bayesian Analysis of Accelerated Molecular Dynamics Simulations. J Chem Theory Comput (2017) 0.75
Ubiquitin Chain Enrichment Middle-Down Mass Spectrometry Enables Characterization of Branched Ubiquitin Chains in Cellulo. Anal Chem (2017) 0.75
Dynamic ubiquitin signaling in cell cycle regulation. J Cell Biol (2017) 0.75
Ubiquitin enzymes in the regulation of immune responses. Crit Rev Biochem Mol Biol (2017) 0.75
Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome. J Mol Biol (2017) 0.75
Why Ubiquitin Has Not Evolved. Int J Mol Sci (2017) 0.75
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature (2002) 14.63
RING domain E3 ubiquitin ligases. Annu Rev Biochem (2009) 12.55
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature (2004) 12.41
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell (1993) 12.41
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85
TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature (2001) 11.84
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell (2000) 10.90
A proteomics approach to understanding protein ubiquitination. Nat Biotechnol (2003) 10.51
Recognition of the polyubiquitin proteolytic signal. EMBO J (2000) 10.12
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science (1989) 9.68
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature (2007) 8.87
A proteolytic pathway that recognizes ubiquitin as a degradation signal. J Biol Chem (1995) 7.79
TRAF6 is a signal transducer for interleukin-1. Nature (1996) 7.38
Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
The ubiquitin code. Annu Rev Biochem (2012) 7.08
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell (1999) 6.04
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell (2009) 5.96
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol (2008) 5.90
Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell (2010) 5.83
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell (2009) 5.76
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science (2011) 5.46
Building ubiquitin chains: E2 enzymes at work. Nat Rev Mol Cell Biol (2009) 5.41
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell (2008) 5.37
A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting. Cell (2005) 4.97
A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J (2006) 4.95
Linear ubiquitination prevents inflammation and regulates immune signalling. Nature (2011) 4.85
Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol (2008) 4.68
Direct activation of protein kinases by unanchored polyubiquitin chains. Nature (2009) 4.65
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell (2008) 4.33
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature (2011) 4.14
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature (2009) 4.12
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell (2009) 4.11
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell (2011) 4.00
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat Rev Mol Cell Biol (2009) 3.95
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep (2009) 3.94
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex. Nature (2011) 3.77
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. J Biol Chem (2007) 3.68
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol (2010) 3.68
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature (2013) 3.57
A ubiquitin mutant with specific defects in DNA repair and multiubiquitination. Mol Cell Biol (1995) 3.56
Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34. Cell (2005) 3.44
Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature (2014) 3.36
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. Biochem J (2014) 3.35
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature (2014) 3.26
Global identification of modular cullin-RING ligase substrates. Cell (2011) 3.13
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol (2014) 3.12
Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer. Cell (2001) 3.09
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature (2015) 2.96
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Cell (2013) 2.91
Ubiquitin-dependent regulation of COPII coat size and function. Nature (2012) 2.88
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell (2006) 2.87
A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell (2009) 2.81
SUMO-targeted ubiquitin ligases in genome stability. EMBO J (2007) 2.77
Identification of a physiological E2 module for the human anaphase-promoting complex. Proc Natl Acad Sci U S A (2009) 2.65
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell (2011) 2.58
AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol (2004) 2.58
Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem (2012) 2.53
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell (2012) 2.53
K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody. Mol Cell (2010) 2.52
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Mol Cell (2014) 2.52
Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain. Cell (2000) 2.51
Ubiquitin-dependent proteolytic control of SUMO conjugates. J Biol Chem (2007) 2.44
The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Proc Natl Acad Sci U S A (2006) 2.41
Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair. Cell (2012) 2.36
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol (2010) 2.31
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. Nat Cell Biol (2009) 2.29
Microtubule-dependent regulation of mitotic protein degradation. Mol Cell (2014) 2.24
K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. Mol Cell (2014) 2.23
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J (2009) 2.17
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev (2012) 2.16
UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proc Natl Acad Sci U S A (2010) 2.15
The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation. J Biol Chem (2007) 2.14
Novel multiubiquitin chain linkages catalyzed by the conjugating enzymes E2EPF and RAD6 are recognized by 26 S proteasome subunit 5. J Biol Chem (1996) 2.10
Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation. Curr Biol (1996) 2.10
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase. Nat Chem Biol (2010) 2.09
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell (2013) 2.05
Mechanism of phospho-ubiquitin-induced PARKIN activation. Nature (2015) 2.02
The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases. Nat Cell Biol (2010) 2.02
Enhanced protein degradation by branched ubiquitin chains. Cell (2014) 2.02
Regulation of ubiquitin chain initiation to control the timing of substrate degradation. Mol Cell (2011) 2.01
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci U S A (2013) 1.97
Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. Mol Cell (2012) 1.94
Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome. EMBO J (2009) 1.93
Engineering and structural characterization of a linear polyubiquitin-specific antibody. J Mol Biol (2011) 1.93
Conformational switching of the 26S proteasome enables substrate degradation. Nat Struct Mol Biol (2013) 1.90
SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev (2012) 1.90
The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy. Mol Cell (2015) 1.90
K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway. J Cell Biol (2009) 1.90
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell (2009) 1.82
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science (2010) 1.77
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev (2010) 1.74
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature (2013) 1.70
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell (2012) 1.66
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature (2014) 1.66
Cell-fate determination by ubiquitin-dependent regulation of translation. Nature (2015) 1.55