Published in Cell on March 04, 2011
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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol (2012) 3.42
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Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circ Res (2015) 1.03
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KAP1 regulates gene networks controlling T-cell development and responsiveness. FASEB J (2012) 1.02
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ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. J Neurosci (2013) 1.02
Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma. Hepatology (2012) 1.01
Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function. Hum Mol Genet (2012) 1.01
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Animal models of the non-motor features of Parkinson's disease. Neurobiol Dis (2012) 1.00
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Declines in Drp1 and parkin expression underlie DNA damage-induced changes in mitochondrial length and neuronal death. J Neurosci (2013) 0.99
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The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease. Sci Rep (2014) 0.98
MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. Elife (2014) 0.97
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Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation. PLoS One (2012) 0.95
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Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol Cell Biol (2013) 0.93
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Parkin plays a role in sporadic Parkinson's disease. Neurodegener Dis (2013) 0.93
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Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn (2012) 0.91
Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder. Nat Commun (2014) 0.91
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