Published in Cell on February 06, 2009
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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell (2010) 4.73
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature (2009) 4.30
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BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol (2009) 3.79
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Nature (2009) 3.62
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A (2010) 3.31
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature (2011) 3.30
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol (2010) 3.27
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Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol Cell (2011) 2.46
Ubiquitin signalling in DNA replication and repair. Nat Rev Mol Cell Biol (2010) 2.41
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat Cell Biol (2009) 2.37
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DNA damage signaling in response to double-strand breaks during mitosis. J Cell Biol (2010) 2.30
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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage. Nature (2015) 2.16
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Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80. EMBO J (2009) 2.14
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PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol Cell (2013) 1.95
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A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol (2010) 1.90
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair. EMBO J (2010) 1.86
The ubiquitin landscape at DNA double-strand breaks. J Cell Biol (2009) 1.86
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol (2010) 1.82
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription. Genes Dev (2012) 1.81
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol (2010) 1.80
A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. PLoS Biol (2010) 1.77
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. EMBO J (2010) 1.75
53BP1: pro choice in DNA repair. Trends Cell Biol (2013) 1.75
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Chromatin and the genome integrity network. Nat Rev Genet (2013) 1.72
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The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol (2012) 1.64
Chromatin dynamics and the repair of DNA double strand breaks. Cell Cycle (2011) 1.63
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Mol Cell (2012) 1.58
RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Dev Cell (2010) 1.57
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
A two-step mechanism for TRF2-mediated chromosome-end protection. Nature (2013) 1.55
BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol Cell Biol (2011) 1.52
REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature (2015) 1.50
Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci (2009) 1.49
Modulation of DNA damage and repair pathways by human tumour viruses. Viruses (2015) 1.49
DNA-damage response and repair activities at uncapped telomeres depend on RNF8. Nat Cell Biol (2011) 1.49
DNA damage response: three levels of DNA repair regulation. Cold Spring Harb Perspect Biol (2013) 1.48
A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. Cell Cycle (2012) 1.46
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RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage. Sci Signal (2012) 1.40
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Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks. J Cell Biol (2012) 1.37
The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0. PLoS Pathog (2011) 1.37
RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX. BMC Mol Biol (2009) 1.34
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. J Exp Med (2010) 1.33
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol Cell (2010) 1.32
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Double strand break repair functions of histone H2AX. Mutat Res (2013) 1.31
The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol Cell Biol (2011) 1.31
Push back to respond better: regulatory inhibition of the DNA double-strand break response. Nat Rev Mol Cell Biol (2013) 1.29
Monoubiquitination of H2AX protein regulates DNA damage response signaling. J Biol Chem (2011) 1.29
Links between genome integrity and BRCA1 tumor suppression. Trends Biochem Sci (2012) 1.26
Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. J Biol Chem (2010) 1.26
A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure. EMBO J (2012) 1.24
The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proc Natl Acad Sci U S A (2009) 1.24
BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. Mol Cell (2009) 1.23
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet (2011) 1.23
DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger. J Cell Biol (2012) 1.22
The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. J Biol Chem (2010) 1.22
Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia. Cell Death Differ (2011) 1.21
The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases. J Biol Chem (2013) 1.20
Primary antibody deficiencies. Nat Rev Immunol (2013) 1.20
UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway. Mol Cell Biol (2010) 1.18
CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage. Nucleic Acids Res (2012) 1.16
Give me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling events. Cell Cycle (2011) 1.16
MDC1: The art of keeping things in focus. Chromosoma (2010) 1.15
Pathway choice in DNA double strand break repair: observations of a balancing act. Genome Integr (2012) 1.13
The increasing complexity of the ubiquitin code. Nat Cell Biol (2016) 1.13
Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex. J Biol Chem (2010) 1.12
USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response. Genes Dev (2016) 1.12
Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. PLoS Genet (2014) 1.10
The ATM signaling network in development and disease. Front Genet (2013) 1.09
Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins. Breast Cancer Res (2010) 1.09
The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A. Nat Commun (2014) 1.07
Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1. Cell Death Differ (2011) 1.07
USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15. Cell Cycle (2013) 1.07
The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. J Biol Chem (2013) 1.07
H2AX post-translational modifications in the ionizing radiation response and homologous recombination. Cell Cycle (2010) 1.06
Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain. Mol Cell (2012) 1.06
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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89
MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell (2006) 5.33
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (2010) 4.69
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods (2013) 4.34
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
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Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature (2006) 3.81
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Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science (2013) 3.33
Mitosis inhibits DNA double-strand break repair to guard against telomere fusions. Science (2014) 3.31
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ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells. J Immunol (2006) 2.99
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Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol (2005) 2.64
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