Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 27249024)

Published in PLoS One on June 01, 2016

Authors

Yeon-Jung Kim1, Heun-Sik Lee1, Yun Kyoung Kim1, Suyeon Park1, Jeong-Min Kim1, Jun Ho Yun1, Ho-Yeong Yu1, Bong-Jo Kim1

Author Affiliations

1: Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Korea.

Articles cited by this

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46

Genetic studies of body mass index yield new insights for obesity biology. Nature (2015) 8.27

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39

Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One (2007) 4.92

Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation (1998) 4.89

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50

Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes (2008) 3.45

Health risks associated with overweight and obesity. Obes Rev (2007) 2.71

Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes (2012) 2.62

C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J Exp Med (2000) 2.57

Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity (Silver Spring) (2010) 2.15

Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes (2008) 2.12

Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes. Diabetes (2006) 1.75

FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med Genet (2010) 1.38

Genetic variation in metabolic phenotypes: study designs and applications. Nat Rev Genet (2012) 1.38

Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition Study. Diabetes Metab Res Rev (2009) 1.28

Human metabolic correlates of body mass index. Metabolomics (2014) 1.24

FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Hum Mol Genet (2014) 1.11

Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans. Clin Chim Acta (2010) 1.08

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes (2013) 1.06

Relationship between obesity and serum markers of oxidative stress and inflammation in Japanese. Asian Pac J Cancer Prev (2003) 1.04

Metabolomics platforms for genome wide association studies--linking the genome to the metabolome. Curr Opin Biotechnol (2012) 0.99

Association of the common FTO-rs9939609 polymorphism with type 2 diabetes, independent of obesity-related traits in a Vietnamese population. Gene (2012) 0.93

Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146. PLoS One (2013) 0.90

Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma. Allergy (2013) 0.89

Relationship between the lipidome, inflammatory markers and insulin resistance. Mol Biosyst (2014) 0.84

Genomic and metabolomic profile associated to microalbuminuria. PLoS One (2014) 0.82

[Validity of indices (BMI, Rohrer index, Broca method) for assessment of obesity]. Nihon Rinsho (2009) 0.82

Significance of two obesity indices, Broca-Katsura and Quetelet, compared with Abdel-Malek index. Sangyo Igaku (1993) 0.77

[Validity of various indices of obesity calculated from height and weight data for adult males use of the underwater-weighing method as a reference]. Nihon Koshu Eisei Zasshi (2001) 0.77

Body mass index (BMI) is a reliable index to estimate obesity as a risk factor for deteriorating health. Tokushima J Exp Med (1996) 0.77

Evaluation of validity of five weight-height obesity indices. Fukuoka Igaku Zasshi (1993) 0.77

Body shape analyses of large persons in South Korea. Ergonomics (2013) 0.76