MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesis.

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Published in Cell Res on June 03, 2016

Authors

Jinzhen Guo1,2, Liya Gu2, Michael Leffak3, Guo-Min Li1,2

Author Affiliations

1: Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing 100084, China.
2: Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1450 Biggy Street, Los Angeles, CA 90033, USA.
3: Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.

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