Published in J Biol Chem on November 24, 2000
Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology (2008) 5.19
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87
A universal protein-protein interaction motif in the eubacterial DNA replication and repair systems. Proc Natl Acad Sci U S A (2001) 2.40
DNA mismatch repair: molecular mechanism, cancer, and ageing. Mech Ageing Dev (2008) 2.40
hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci. Genes Dev (2001) 2.11
Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates. Cell (2011) 2.02
Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I. Proc Natl Acad Sci U S A (2001) 1.84
Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. Ann Bot (2010) 1.81
exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair. Mol Cell Biol (2001) 1.79
DNA replication fidelity and cancer. Semin Cancer Biol (2010) 1.69
hMutSbeta is required for the recognition and uncoupling of psoralen interstrand cross-links in vitro. Mol Cell Biol (2002) 1.58
The N terminus of Saccharomyces cerevisiae Msh6 is an unstructured tether to PCNA. Mol Cell (2007) 1.51
Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae. Mol Cell Biol (2002) 1.49
Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA. Genes Dev (2007) 1.47
Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication. Science (2011) 1.34
Isolation and characterization of new proliferating cell nuclear antigen (POL30) mutator mutants that are defective in DNA mismatch repair. Mol Cell Biol (2002) 1.22
Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae. Curr Genet (2003) 1.21
Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A. Mol Cell Biol (2002) 1.18
DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae. Genetics (2013) 1.17
DNA repair in antibody somatic hypermutation. Trends Immunol (2006) 1.17
The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. J Biol Chem (2008) 1.15
A proteomic characterization of factors enriched at nascent DNA molecules. Cell Rep (2013) 1.15
DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase. Mol Cell Biol (2005) 1.14
Loading clamps for DNA replication and repair. DNA Repair (Amst) (2009) 1.12
Oligonucleotide transformation of yeast reveals mismatch repair complexes to be differentially active on DNA replication strands. Proc Natl Acad Sci U S A (2007) 1.09
Role of DNA mismatch repair and double-strand break repair in genome stability and antifungal drug resistance in Candida albicans. Eukaryot Cell (2007) 1.03
Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function. Mol Cell Biol (2009) 1.02
MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells. PLoS One (2012) 1.01
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA. PLoS One (2012) 1.01
Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA). Nucleic Acids Res (2007) 1.00
Physical and functional interactions between Escherichia coli MutY glycosylase and mismatch repair protein MutS. J Bacteriol (2006) 0.99
Regulation of the DNA replication fork: a way to fight genomic instability. Chromosoma (2004) 0.98
PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells. Nucleic Acids Res (2005) 0.97
Physical and functional interaction of human nuclear uracil-DNA glycosylase with proliferating cell nuclear antigen. DNA Repair (Amst) (2005) 0.97
Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins. Proc Natl Acad Sci U S A (2013) 0.97
MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. J Biol Chem (2010) 0.96
Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks. DNA Repair (Amst) (2010) 0.95
MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites. PLoS One (2010) 0.95
Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis. Proc Natl Acad Sci U S A (2015) 0.94
Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. J Biol Chem (2009) 0.92
Spatiotemporally different DNA repair systems participate in Epstein-Barr virus genome maturation. J Virol (2011) 0.91
Involvement of the beta clamp in methyl-directed mismatch repair in vitro. J Biol Chem (2009) 0.91
Role of proliferating cell nuclear antigen interactions in the mismatch repair-dependent processing of mitotic and meiotic recombination intermediates in yeast. Genetics (2008) 0.91
Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. Mutat Res (2013) 0.91
Regulation of interactions with sliding clamps during DNA replication and repair. Curr Genomics (2009) 0.89
Multiple functions for the N-terminal region of Msh6. Nucleic Acids Res (2007) 0.89
Exonuclease 1-dependent and independent mismatch repair. DNA Repair (Amst) (2015) 0.88
A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cells. Cell Cycle (2015) 0.87
Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1. DNA Repair (Amst) (2010) 0.87
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1. J Biol Chem (2011) 0.86
A proposal: Evolution of PCNA's role as a marker of newly replicated DNA. DNA Repair (Amst) (2015) 0.85
Human DNA mismatch repair in vitro operates independently of methylation status at CpG sites. Nucleic Acids Res (2001) 0.85
The unstructured linker arms of Mlh1-Pms1 are important for interactions with DNA during mismatch repair. J Mol Biol (2012) 0.83
Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage. DNA Repair (Amst) (2009) 0.83
Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication. Mol Cell Biol (2005) 0.83
Different roles of eukaryotic MutS and MutL complexes in repair of small insertion and deletion loops in yeast. PLoS Genet (2013) 0.82
A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair. DNA Repair (Amst) (2015) 0.82
HTLV-I Tax-Mediated Inactivation of Cell Cycle Checkpoints and DNA Repair Pathways Contribute to Cellular Transformation: "A Random Mutagenesis Model". J Cancer Sci (2015) 0.81
Distinct structural alterations in proliferating cell nuclear antigen block DNA mismatch repair. Biochemistry (2013) 0.81
DNA mismatch repair and Lynch syndrome. J Mol Histol (2006) 0.81
The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis. PLoS Genet (2015) 0.81
Genetic instability in budding and fission yeast-sources and mechanisms. FEMS Microbiol Rev (2015) 0.80
Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage. Nucleic Acids Res (2013) 0.80
Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks. DNA Repair (Amst) (2016) 0.79
New insights into the mechanism of DNA mismatch repair. Chromosoma (2015) 0.78
New insights and challenges in mismatch repair: getting over the chromatin hurdle. DNA Repair (Amst) (2014) 0.78
Human DNA mismatch repair: coupling of mismatch recognition to strand-specific excision. Nucleic Acids Res (2007) 0.77
Base excision repair and the role of MUTYH. Hered Cancer Clin Pract (2007) 0.77
Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I. J Mol Biol (2011) 0.77
MutSα maintains the mismatch repair capability by inhibiting PCNA unloading. Elife (2016) 0.77
Mutations at the Subunit Interface of Yeast Proliferating Cell Nuclear Antigen Reveal a Versatile Regulatory Domain. PLoS One (2016) 0.77
Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells. DNA Repair (Amst) (2015) 0.77
Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells. Oncol Lett (2012) 0.77
The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia. Oncotarget (2015) 0.76
MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesis. Cell Res (2016) 0.76
Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR. DNA Repair (Amst) (2016) 0.76
A Delicate Balance Between Repair and Replication Factors Regulates Recombination Between Divergent DNA Sequences in Saccharomyces cerevisiae. Genetics (2015) 0.76
HNPCC: six new pathogenic mutations. BMC Med Genet (2004) 0.75
Epigenetic Enhancement of the Post-replicative DNA Mismatch Repair of Mammalian Genomes by a Hemi-(m)CpG-Np95-Dnmt1 Axis. Sci Rep (2016) 0.75
Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci U S A (1985) 68.48
Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. Biochemistry (1988) 9.66
The accuracy of reverse transcriptase from HIV-1. Science (1988) 8.24
Efficient site-directed mutagenesis using uracil-containing DNA. Methods Enzymol (1991) 7.94
Fidelity of DNA synthesis. Annu Rev Biochem (1982) 6.54
Plasmid vector pBR322 and its special-purpose derivatives--a review. Gene (1986) 6.52
Mutational specificity of depurination. Proc Natl Acad Sci U S A (1984) 6.51
The Y-family of DNA polymerases. Mol Cell (2001) 6.49
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell (1996) 4.47
DNA polymerase fidelity and the polymerase chain reaction. PCR Methods Appl (1991) 4.31
The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation. J Biol Chem (1986) 4.25
Deoxynucleoside [1-thio]triphosphates prevent proofreading during in vitro DNA synthesis. Proc Natl Acad Sci U S A (1981) 4.14
High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase. Nucleic Acids Res (1990) 4.12
The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations. J Biol Chem (1985) 3.98
Aromatic hydrogen bond in sequence-specific protein DNA recognition. Nat Struct Biol (1996) 3.91
Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. J Biol Chem (1989) 3.80
Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res (1994) 3.63
Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Nat Immunol (2001) 3.60
A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. Biochemistry (1990) 3.51
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity. Proc Natl Acad Sci U S A (1991) 3.44
Heteroduplex repair in extracts of human HeLa cells. J Biol Chem (1991) 3.13
Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro. Mol Cell Biol (1989) 3.00
Infidelity of DNA synthesis associated with bypass of apurinic sites. Proc Natl Acad Sci U S A (1983) 2.95
Low fidelity DNA synthesis by human DNA polymerase-eta. Nature (2000) 2.85
Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem (1994) 2.82
The mutational specificity of DNA polymerases-alpha and -gamma during in vitro DNA synthesis. J Biol Chem (1985) 2.66
Passing the baton in base excision repair. Nat Struct Biol (2000) 2.65
Nucleotide repeats. Slippery DNA and diseases. Nature (1993) 2.56
Analyzing fidelity of DNA polymerases. Methods Enzymol (1995) 2.52
Frameshift mutagenesis by eucaryotic DNA polymerases in vitro. J Biol Chem (1986) 2.40
Depurination-induced infidelity of deoxyribonucleic acid synthesis with purified deoxyribonucleic acid replication proteins in vitro. Biochemistry (1983) 2.38
Pathway engineering for the production of aromatic compounds in Escherichia coli. Nat Biotechnol (1996) 2.36
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. J Biol Chem (1990) 2.36
Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res (1995) 2.35
Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations. Mol Cell Biol (1999) 2.26
On the fidelity of DNA replication. Effect of divalent metal ion activators and deoxyrionucleoside triphosphate pools on in vitro mutagenesis. J Biol Chem (1979) 2.20
DNA loop repair by human cell extracts. Science (1994) 2.19
Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res (1995) 2.17
Fidelity of mammalian DNA polymerases. Science (1981) 2.17
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. Proc Natl Acad Sci U S A (2001) 2.16
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. J Biol Chem (2000) 2.06
Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme. J Biol Chem (1990) 2.06
Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. J Biol Chem (1993) 2.04
Mutagenesis in vitro by DNA polymerase from an RNA tumour virus. Nature (1979) 2.00
Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase delta. Curr Biol (2006) 1.98
Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res (1997) 1.96
Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair. J Biol Chem (2001) 1.94
Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates. Proc Natl Acad Sci U S A (1992) 1.93
The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit. J Biol Chem (2001) 1.92
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2. Proc Natl Acad Sci U S A (1998) 1.86
International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability. Mutat Res (1994) 1.86
Error rate and specificity of human and murine DNA polymerase eta. J Mol Biol (2001) 1.86
The effects of dNTP pool imbalances on frameshift fidelity during DNA replication. J Biol Chem (1992) 1.85
Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta. J Biol Chem (1996) 1.85
Repeat expansion--all in a flap? Nat Genet (1997) 1.80
Exonucleolytic proofreading during replication of repetitive DNA. Biochemistry (1996) 1.79
DNA-replication fidelity, mismatch repair and genome instability in cancer cells. Eur J Biochem (1996) 1.79
Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine. J Biol Chem (1992) 1.75
Role of glutamic acid-181 in DNA-sequence recognition by the catabolite gene activator protein (CAP) of Escherichia coli: altered DNA-sequence-recognition properties of [Val181]CAP and [Leu181]CAP. Proc Natl Acad Sci U S A (1987) 1.75
Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment). J Biol Chem (1999) 1.71
Functional overlap in mismatch repair by human MSH3 and MSH6. Genetics (1998) 1.70
In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta. Genetics (2001) 1.67
On the fidelity of DNA replication. The accuracy of T4 DNA polymerases in copying phi X174 DNA in vitro. J Biol Chem (1984) 1.65
Mechanism of HIV-1 reverse transcriptase. Termination of processive synthesis on a natural DNA template is influenced by the sequence of the template-primer stem. J Biol Chem (1993) 1.64
Exonucleolytic proofreading by calf thymus DNA polymerase delta. Proc Natl Acad Sci U S A (1987) 1.61
On the fidelity of DNA replication. The accuracy of Escherichia coli DNA polymerase I in copying natural DNA in vitro. J Biol Chem (1980) 1.58
Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain. J Biol Chem (1995) 1.57
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. Science (2001) 1.55
On the fidelity of DNA replication. Effect of the next nucleotide on proofreading. J Biol Chem (1981) 1.53
Effect of reaction pH on the fidelity and processivity of exonuclease-deficient Klenow polymerase. J Biol Chem (1993) 1.51
Frameshift errors initiated by nucleotide misincorporation. Proc Natl Acad Sci U S A (1990) 1.48
The fidelity of DNA polymerase beta during distributive and processive DNA synthesis. J Biol Chem (1999) 1.46
Cloning of the two pyruvate kinase isoenzyme structural genes from Escherichia coli: the relative roles of these enzymes in pyruvate biosynthesis. J Bacteriol (1995) 1.43
Fidelity of mammalian DNA replication and replicative DNA polymerases. Biochemistry (1991) 1.43
Mutagenesis in vitro by depurination of phiX174 dna. Nature (1981) 1.41
Determination of the nucleotide sequence for the glutamate synthase structural genes of Escherichia coli K-12. Gene (1987) 1.41
Purification and properties of wild-type and exonuclease-deficient DNA polymerase II from Escherichia coli. J Biol Chem (1995) 1.40
Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: alteration of DNA binding specificity through alteration of DNA kinking. J Mol Biol (2001) 1.40
The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts. Cancer Res (1998) 1.39
The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair. J Biol Chem (2001) 1.38
Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain. J Biol Chem (1997) 1.37
Cytosine deamination in mismatched base pairs. Biochemistry (1993) 1.35
The use of native T7 DNA polymerase for site-directed mutagenesis. Nucleic Acids Res (1989) 1.34
Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene. Proc Natl Acad Sci U S A (1999) 1.32
Activities and incision patterns of ABC excinuclease on modified DNA containing single-base mismatches and extrahelical bases. J Biol Chem (1986) 1.31
A minor groove binding track in reverse transcriptase. Nat Struct Biol (1997) 1.31
DNA replication fidelity with 8-oxodeoxyguanosine triphosphate. Biochemistry (1994) 1.28
Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat Genet (1996) 1.28
Asymmetric recognition of DNA local distortion. Structure-based functional studies of eukaryotic Msh2-Msh6. J Biol Chem (2001) 1.28
Fidelity of a human cell DNA replication complex. Proc Natl Acad Sci U S A (1988) 1.26
Microsatellite instability and mismatch repair defects in cancer. Mutat Res (1996) 1.25
High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer. J Mol Biol (2001) 1.22
Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain. J Biol Chem (1994) 1.20
Origin of respiratory sinus arrhythmia in conscious humans. An important role for arterial carotid baroreceptors. Circulation (1997) 1.19
Streisinger revisited: DNA synthesis errors mediated by substrate misalignments. Cold Spring Harb Symp Quant Biol (2000) 1.17
Rearrangements of DNA mediated by terminal transferase. Proc Natl Acad Sci U S A (1986) 1.17
A thumb subdomain mutant of the large fragment of Escherichia coli DNA polymerase I with reduced DNA binding affinity, processivity, and frameshift fidelity. J Biol Chem (1996) 1.17
Mutator phenotypes of common polymorphisms and missense mutations in MSH2. Curr Biol (1999) 1.15