Published in Nat Rev Immunol on June 06, 2016
Crosstalk of cell polarity signaling pathways. Protoplasma (2017) 0.81
Mutations affecting segment number and polarity in Drosophila. Nature (1980) 18.72
The immunological synapse: a molecular machine controlling T cell activation. Science (1999) 17.41
Three-dimensional segregation of supramolecular activation clusters in T cells. Nature (1998) 14.14
Intraflagellar transport. Nat Rev Mol Cell Biol (2002) 10.86
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature (1989) 9.29
Vertebrate Smoothened functions at the primary cilium. Nature (2005) 9.24
Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21
The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet (2010) 8.81
Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature (2003) 8.38
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity (2006) 6.93
The primary cilium as the cell's antenna: signaling at a sensory organelle. Science (2006) 6.79
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet (2005) 6.15
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun (2011) 5.95
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
Reconstructions of centriole formation and ciliogenesis in mammalian lungs. J Cell Sci (1968) 5.07
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. J Exp Med (2010) 4.90
The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity (2001) 4.72
ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol (2006) 4.64
Combined immunodeficiency associated with DOCK8 mutations. N Engl J Med (2009) 4.52
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell (2000) 4.45
Centrosome polarization delivers secretory granules to the immunological synapse. Nature (2006) 4.28
The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol (2013) 3.84
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci (2009) 3.74
Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J Exp Med (2005) 3.41
Cep97 and CP110 suppress a cilia assembly program. Cell (2007) 3.15
Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity (2007) 3.14
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity (2005) 2.97
Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse. Nat Cell Biol (2009) 2.94
Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events. Nat Immunol (2011) 2.75
Primary cilia are specialized calcium signalling organelles. Nature (2013) 2.63
Secretory mechanisms in cell-mediated cytotoxicity. Annu Rev Cell Dev Biol (2007) 2.63
The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer (2011) 2.60
Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease? Nat Rev Genet (2005) 2.55
Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes. Immunity (2004) 2.47
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature (2005) 2.42
Regulation of leading edge microtubule and actin dynamics downstream of Rac1. J Cell Biol (2003) 2.41
Direct recording and molecular identification of the calcium channel of primary cilia. Nature (2013) 2.27
Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells. J Cell Biol (1982) 2.26
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling. Dev Cell (2015) 2.26
Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing. Immunity (2002) 2.21
Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J Cell Biol (2007) 2.19
Recruitment of dynein to the Jurkat immunological synapse. Proc Natl Acad Sci U S A (2006) 2.15
LFA-1 contributes an early signal for NK cell cytotoxicity. J Immunol (2004) 2.00
Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1. J Biol Chem (2003) 1.99
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Nature (2014) 1.99
Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Immunity (2009) 1.98
Cytoskeletal regulation: rich in lipids. Nat Rev Mol Cell Biol (2004) 1.94
Cutting edge: MHC class II-restricted killing in vivo during viral infection. J Immunol (2005) 1.93
Clinical experience with Hedgehog pathway inhibitors. J Clin Oncol (2010) 1.93
Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse. PLoS Biol (2011) 1.92
The cilium secretes bioactive ectosomes. Curr Biol (2013) 1.88
Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism. J Cell Biol (1998) 1.85
Hedgehog signaling controls T cell killing at the immunological synapse. Science (2013) 1.84
Primary cilia in normal and pathological tissues. Pathobiology (1995) 1.84
Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells. Mol Biol Cell (2012) 1.82
Actin depletion initiates events leading to granule secretion at the immunological synapse. Immunity (2015) 1.80
MTOC translocation modulates IS formation and controls sustained T cell signaling. J Cell Biol (2008) 1.75
Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex. Blood (2012) 1.75
Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation. Immunity (2011) 1.75
Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells. Nat Immunol (2009) 1.72
Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy. PLoS Biol (2011) 1.70
Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output. Dev Cell (2015) 1.69
Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse. Sci Signal (2010) 1.69
The immunological synapse: a focal point for endocytosis and exocytosis. J Cell Biol (2010) 1.68
Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles. J Immunol (1999) 1.65
Centriole distal appendages promote membrane docking, leading to cilia initiation. Genes Dev (2013) 1.65
The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells. J Mol Cell Immunol (1985) 1.62
Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells. Proc Natl Acad Sci U S A (2001) 1.61
Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. J Immunol (2003) 1.58
A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells. J Cell Biol (2011) 1.52
Sonic hedgehog signalling in T-cell development and activation. Nat Rev Immunol (2007) 1.51
The mechanism of T-cell mediated cytotoxicity. VI. T-cell projections and their role in target cell killing. Immunology (1979) 1.47
A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol (2010) 1.42
Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem (2011) 1.41
IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport. Dev Cell (2012) 1.40
Diacylglycerol and protein kinase D localization during T lymphocyte activation. Immunity (2006) 1.40
A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells. Nat Immunol (2011) 1.39
Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation. Immunity (2011) 1.35
TGF-β signaling is associated with endocytosis at the pocket region of the primary cilium. Cell Rep (2013) 1.34
Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol (2013) 1.31
Imaging techniques for assaying lymphocyte activation in action. Nat Rev Immunol (2011) 1.27
Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage. J Cell Biol (2013) 1.26
Cilia and centrioles of the rat adrenal cortex. J Anat (1967) 1.26
Confocal analysis of primary cilia structure and colocalization with the Golgi apparatus in chondrocytes and aortic smooth muscle cells. Cell Biol Int (1997) 1.23
The mechanism of T cell mediated cytotoxicity. V. Morphological studies by electron microscopy. Proc R Soc Lond B Biol Sci (1977) 1.23
Integration of the movement of signaling microclusters with cellular motility in immunological synapses. Nat Immunol (2012) 1.23
NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol (2012) 1.22
VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites. Nat Immunol (2013) 1.21
How do cilia organize signalling cascades? Philos Trans R Soc Lond B Biol Sci (2014) 1.19
CD4+ T-cell synapses involve multiple distinct stages. Proc Natl Acad Sci U S A (2011) 1.19
Ultrastructure of cilia and flagella - back to the future! Biol Cell (2011) 1.18
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites. Cell Signal (2007) 1.16
Casein kinase I delta controls centrosome positioning during T cell activation. J Cell Biol (2011) 1.15
Cdc42-mediated MTOC polarization in dendritic cells controls targeted delivery of cytokines at the immune synapse. J Exp Med (2010) 1.13
Centrosome docking at the immunological synapse is controlled by Lck signaling. J Cell Biol (2011) 1.13
Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II. Proc Natl Acad Sci U S A (2013) 1.12
Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse. J Exp Med (2013) 1.12
C. elegans ciliated sensory neurons release extracellular vesicles that function in animal communication. Curr Biol (2014) 1.11
Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway. Elife (2015) 1.10