Published in Nat Rev Mol Cell Biol on January 01, 2006
Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer (2010) 11.16
Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol (2009) 3.83
Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol (2011) 3.68
Paxillin comes of age. J Cell Sci (2008) 3.57
Integrin signalling at a glance. J Cell Sci (2009) 3.28
Integrins in cell migration. Cold Spring Harb Perspect Biol (2011) 3.15
Kindlin-2 controls bidirectional signaling of integrins. Genes Dev (2008) 3.15
Integrin signalling adaptors: not only figurants in the cancer story. Nat Rev Cancer (2010) 2.94
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. J Cell Biol (2007) 2.79
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat Chem Biol (2010) 2.53
Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol (2007) 2.48
Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev (2006) 2.29
Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner. Curr Biol (2013) 2.20
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
Ancient origin of the integrin-mediated adhesion and signaling machinery. Proc Natl Acad Sci U S A (2010) 1.81
Anchoring junctions as drug targets: role in contraceptive development. Pharmacol Rev (2008) 1.76
Fibroblast activation and myofibroblast generation in obstructive nephropathy. Nat Rev Nephrol (2009) 1.76
Pseudokinases-remnants of evolution or key allosteric regulators? Curr Opin Struct Biol (2010) 1.76
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol (2007) 1.63
The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol Cell (2009) 1.62
Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol (2007) 1.60
Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature (2009) 1.55
Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization. J Cell Biol (2008) 1.53
Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. Circ Res (2009) 1.46
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature (2009) 1.45
Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol (2009) 1.45
Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition. J Cell Biol (2012) 1.45
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J (2010) 1.45
Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene Expression. Oxid Med Cell Longev (2015) 1.39
Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria. Kidney Int (2010) 1.36
Structural determinants of integrin binding to the talin rod. J Biol Chem (2009) 1.35
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J Cell Biol (2009) 1.33
Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. J Clin Invest (2007) 1.33
Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology (2008) 1.31
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation. PLoS One (2010) 1.31
β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. Mol Biol Cell (2013) 1.29
The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. J Mol Biol (2009) 1.25
Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage. J Cell Biol (2008) 1.24
The mechanism of kindlin-mediated activation of integrin αIIbβ3. Curr Biol (2013) 1.22
Kindlin-2 is required for myocyte elongation and is essential for myogenesis. BMC Cell Biol (2008) 1.22
The structural basis of integrin-linked kinase-PINCH interactions. Proc Natl Acad Sci U S A (2008) 1.21
The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase. Mol Biol Cell (2007) 1.16
Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J (2009) 1.15
Integrin β1 mediates vaccinia virus entry through activation of PI3K/Akt signaling. J Virol (2012) 1.14
Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation. J Signal Transduct (2011) 1.14
Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis. Neoplasia (2008) 1.13
Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem (2011) 1.12
Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development (2009) 1.11
The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells. Eur J Cell Biol (2008) 1.11
Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. J Cell Commun Signal (2009) 1.11
Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Mol Biol Cell (2008) 1.11
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha. J Clin Invest (2010) 1.09
Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy. PLoS One (2011) 1.09
A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion. Blood (2008) 1.09
The extracellular matrix as an adhesion checkpoint for mammary epithelial function. Int J Biochem Cell Biol (2006) 1.09
Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation (2009) 1.08
Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism. J Cell Physiol (2010) 1.07
Differential gene expression in a coculture model of angiogenesis reveals modulation of select pathways and a role for Notch signaling. Physiol Genomics (2008) 1.05
Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition. Mol Biol Cell (2012) 1.04
Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. J Biol Chem (2008) 1.03
Imaging key biomarkers of tumor angiogenesis. Theranostics (2012) 1.03
Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase. Proc Natl Acad Sci U S A (2007) 1.03
Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction. Genes Dev (2009) 1.01
Integrins and integrin-associated proteins in the cardiac myocyte. Circ Res (2014) 1.00
LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration. FASEB J (2012) 1.00
The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. J Biol Chem (2008) 1.00
Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions. J Biol Chem (2009) 0.99
Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. J Biol Chem (2008) 0.99
Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK): cross-validation of the pseudokinase. J Biol Chem (2011) 0.99
Integrin signaling and lung cancer. Cell Adh Migr (2010) 0.99
The small molecule inhibitor QLT0267 Radiosensitizes squamous cell carcinoma cells of the head and neck. PLoS One (2009) 0.98
Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics. PLoS One (2012) 0.97
β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells. PLoS One (2014) 0.96
A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rats. Gut (2006) 0.96
Gene transcriptional networks integrate microenvironmental signals in human breast cancer. Integr Biol (Camb) (2010) 0.96
The development of the myotendinous junction. A review. Muscles Ligaments Tendons J (2012) 0.96
Anion exchanger 1 interacts with nephrin in podocytes. J Am Soc Nephrol (2010) 0.96
Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency. Am J Pathol (2007) 0.95
Signals and cells involved in regulating liver regeneration. Cells (2012) 0.94
Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation. Biochem Biophys Res Commun (2006) 0.94
Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation. Mol Cell Biol (2007) 0.94
Integrin beta3 down-regulates invasive features of ovarian cancer cells in SKOV3 cell subclones. J Cancer Res Clin Oncol (2008) 0.94
Immunopathologies linked to integrin signalling. Semin Immunopathol (2010) 0.94
Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Development (2010) 0.93
tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling. Am J Pathol (2010) 0.93
Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression. Cancer Res (2010) 0.93
Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Mol Biol Cell (2009) 0.93
Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol. Elife (2014) 0.92
Mechanical stimuli and IL-13 interact at integrin adhesion complexes to regulate expression of smooth muscle myosin heavy chain in airway smooth muscle tissue. Am J Physiol Lung Cell Mol Physiol (2011) 0.92
Regulation of cell-matrix contacts and beta-catenin signaling in VSMC by integrin-linked kinase: implications for intimal thickening. Basic Res Cardiol (2007) 0.92
Structural basis for paxillin binding and focal adhesion targeting of β-parvin. J Biol Chem (2012) 0.92
Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J (2011) 0.92
Role of the RNA-binding protein IMP-2 in muscle cell motility. Mol Cell Biol (2010) 0.91
mda-9/Syntenin protein positively regulates the activation of Akt protein by facilitating integrin-linked kinase adaptor function during adhesion to type I collagen. J Biol Chem (2011) 0.91
Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review). Int J Oncol (2015) 0.90
The function of integrin-linked kinase in normal and activated stellate cells: implications for fibrogenesis in wound healing. Lab Invest (2011) 0.90
Novel actions of tissue-type plasminogen activator in chronic kidney disease. Front Biosci (2008) 0.90
Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell (2008) 5.02
Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med (2008) 4.55
The tail of integrins, talin, and kindlins. Science (2009) 4.51
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell (2006) 4.43
Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev (2009) 3.57
Kindlin-2 controls bidirectional signaling of integrins. Genes Dev (2008) 3.15
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med (2009) 2.85
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2008) 2.77
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev (2003) 2.68
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med (2006) 2.59
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol (2013) 2.52
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol (2008) 2.46
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities. Development (2004) 2.44
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med (2007) 2.43
The Kindlins: subcellular localization and expression during murine development. Exp Cell Res (2006) 2.36
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron (2003) 2.31
Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails. J Cell Sci (2009) 2.29
The integrin-actin connection, an eternal love affair. EMBO J (2003) 2.26
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev (2003) 2.21
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol (2005) 2.10
The role of laminin in embryonic cell polarization and tissue organization. Dev Cell (2003) 2.05
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood (2010) 2.04
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development (2004) 2.04
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell (2007) 2.00
Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Cell Stem Cell (2008) 1.98
Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res (2002) 1.96
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep (2011) 1.96
Integrins in invasive growth. J Clin Invest (2002) 1.96
The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol (2008) 1.89
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. PLoS Genet (2008) 1.78
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med (2006) 1.75
Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A (2003) 1.74
Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol (2006) 1.73
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72
Integrin trafficking regulated by Rab21 is necessary for cytokinesis. Dev Cell (2008) 1.70
Laminin: the crux of basement membrane assembly. J Cell Biol (2004) 1.69
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res (2008) 1.68
A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy. J Clin Invest (2008) 1.67
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol (2007) 1.63
Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep (2003) 1.63
Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J (2005) 1.61
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest (2014) 1.59
Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med (2009) 1.59
The N terminus of monoamine transporters is a lever required for the action of amphetamines. J Biol Chem (2010) 1.58
The Kindlin protein family: new members to the club of focal adhesion proteins. Trends Cell Biol (2009) 1.57
Cylindroma as tumor of hair follicle origin. J Invest Dermatol (2006) 1.56
Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature (2009) 1.55
Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol (2007) 1.53
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail. Nat Cell Biol (2012) 1.48
Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol Cell Biol (2002) 1.48
Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol (2011) 1.46
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature (2009) 1.45
Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability. Circ Res (2008) 1.43
Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action. Mol Pharmacol (2005) 1.42
Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity (2002) 1.38
Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape. J Cell Sci (2008) 1.38
Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts. Dev Biol (2006) 1.37
Regulation of neural progenitor proliferation and survival by beta1 integrins. J Cell Sci (2005) 1.34
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage. J Cell Sci (2005) 1.34
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J Cell Biol (2009) 1.33
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest (2013) 1.32
Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function. EMBO J (2007) 1.32
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol (2011) 1.32
Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol Cell Biol (2002) 1.31
Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. FASEB J (2003) 1.28
Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A (2009) 1.27
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development (2009) 1.27
Integrin-linked kinase: integrin's mysterious partner. Curr Opin Cell Biol (2004) 1.27
Integrins are required for the differentiation of visceral endoderm. J Cell Sci (2009) 1.26
Identification of an additional interaction domain in transmembrane domains 11 and 12 that supports oligomer formation in the human serotonin transporter. J Biol Chem (2003) 1.25
Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes. J Cell Sci (2006) 1.24
Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis. Sci Signal (2009) 1.24
Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage. J Cell Biol (2008) 1.24
The mechanism of kindlin-mediated activation of integrin αIIbβ3. Curr Biol (2013) 1.22
Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep (2013) 1.22
Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. J Cell Sci (2005) 1.22
Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin. Methods Enzymol (2007) 1.21
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J (2009) 1.21
Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration. J Neurosci (2012) 1.21
The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain. Gene Expr Patterns (2003) 1.21
Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision. PLoS Biol (2007) 1.20
Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1). J Biol Chem (2004) 1.20
Mechanoinduction of lymph vessel expansion. EMBO J (2011) 1.19
Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation. J Cell Sci (2009) 1.19
Profilin 1 is required for abscission during late cytokinesis of chondrocytes. EMBO J (2009) 1.19
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. J Exp Med (2012) 1.18
Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Dev Biol (2007) 1.16
Adult murine hematopoiesis can proceed without beta1 and beta7 integrins. Blood (2006) 1.16
PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp Cell Res (2003) 1.16