Published in Cell Death Dis on June 30, 2016
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Monocyte and macrophage heterogeneity. Nat Rev Immunol (2005) 24.36
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature (2000) 13.45
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res (2005) 11.88
Developmental origin of fat: tracking obesity to its source. Cell (2007) 8.80
Macrophage biology in development, homeostasis and disease. Nature (2013) 8.28
PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab (2007) 7.19
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell (1998) 5.78
Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol (2011) 4.68
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes (2008) 4.56
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest (2010) 4.56
Tissue-resident macrophages. Nat Immunol (2013) 4.09
In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding. Cell Metab (2012) 3.90
Alternative macrophage activation and metabolism. Annu Rev Pathol (2011) 3.59
The adipose organ. Prostaglandins Leukot Essent Fatty Acids (2005) 3.34
Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res (2008) 3.03
Apoptotic cell clearance: basic biology and therapeutic potential. Nat Rev Immunol (2014) 2.59
Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab (2013) 2.23
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A (2007) 2.18
12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity (2012) 2.06
Resolution of inflammation: an integrated view. EMBO Mol Med (2013) 2.01
Orchestration of metabolism by macrophages. Cell Metab (2012) 1.92
Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J Biol Chem (1996) 1.91
Functional and pathological roles of the 12- and 15-lipoxygenases. Prog Lipid Res (2010) 1.72
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates. EMBO J (2009) 1.70
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Am J Physiol Endocrinol Metab (2008) 1.52
Metabolic and cellular plasticity in white adipose tissue II: role of peroxisome proliferator-activated receptor-alpha. Am J Physiol Endocrinol Metab (2005) 1.51
12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity (Silver Spring) (2009) 1.46
Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab (2013) 1.45
The immune system as a sensor of the metabolic state. Immunity (2013) 1.45
Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab (2013) 1.36
12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One (2009) 1.34
Cellular origins of cold-induced brown adipocytes in adult mice. FASEB J (2014) 1.34
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases. Bioorg Med Chem (2006) 1.29
Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab (2010) 1.20
Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity. J Biol Chem (2011) 1.13
Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta (2013) 1.12
p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression. Nat Commun (2014) 1.06
A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis (1998) 1.04
Adipogenic role of alternatively activated macrophages in β-adrenergic remodeling of white adipose tissue. Am J Physiol Regul Integr Comp Physiol (2015) 0.89
PPARγ and the Innate Immune System Mediate the Resolution of Inflammation. PPAR Res (2015) 0.85
Exploring the activated adipogenic niche: interactions of macrophages and adipocyte progenitors. Cell Cycle (2014) 0.85
12- and 15-lipoxygenases in adipose tissue inflammation. Prostaglandins Other Lipid Mediat (2012) 0.83
Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PLoS One (2014) 0.80