Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial.

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🔗 View Article (PMID 25704439)

Published in Lancet Oncol on February 20, 2015

Authors

Naiyer A Rizvi1, Julien Mazières2, David Planchard3, Thomas E Stinchcombe4, Grace K Dy5, Scott J Antonia6, Leora Horn7, Hervé Lena8, Elisa Minenza9, Bertrand Mennecier10, Gregory A Otterson11, Luis T Campos12, David R Gandara13, Benjamin P Levy14, Suresh G Nair15, Gérard Zalcman16, Jürgen Wolf17, Pierre-Jean Souquet18, Editta Baldini19, Federico Cappuzzo20, Christos Chouaid21, Afshin Dowlati22, Rachel Sanborn23, Ariel Lopez-Chavez24, Christian Grohe25, Rudolf M Huber26, Christopher T Harbison27, Christine Baudelet27, Brian J Lestini27, Suresh S Ramalingam28

Author Affiliations

1: Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address: nar2144@cumc.columbia.edu.
2: Hôpital Larrey, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
3: L'Institut Gustave Roussy, Villejuif, France.
4: University of North Carolina School of Medicine, Chapel Hill, NC, USA.
5: Roswell Park Cancer Institute, Buffalo, NY, USA.
6: H Lee Moffitt Cancer Center, Tampa, FL, USA.
7: Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
8: Centre Hospitalier Universitaire de Rennes, Rennes, France.
9: Ospedale S Maria, Terni, Italy.
10: Nouvel Hôpital Civil Chru de Strasbourg, Strasbourg, France.
11: The Ohio State University Medical Center, Columbus, OH, USA.
12: Oncology Consultants, PA, Houston, TX, USA.
13: University of California Davis Cancer Center, Sacramento, CA, USA.
14: Mount Sinai Beth Israel Comprehensive Cancer Center, New York, NY, USA.
15: Lehigh Valley Hospital, Allentown, PA, USA.
16: Centre Hospitalier Universitaire de Caen, Caen, France.
17: Universitaetsklinik Koeln, Koeln, Germany.
18: Hospices Civils de Lyon, Ch Lyon Sud, Pierre Benite, France.
19: Ospedale Campo Di Marte, Lucca, Italy.
20: Istituto Toscano Tumori, Livorno, Italy.
21: Chi De Creteil, Creteil, France.
22: University Hospitals of Cleveland, Cleveland, OH, USA.
23: Providence Portland Medical Center, Portland, OR, USA.
24: University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
25: Evangelische Lungenklinik Berlin, Berlin, Germany.
26: Klinikum der Universitaet Muenchen-Innenstadt, German Center for Lung Research, Munich, Germany.
27: Bristol-Myers Squibb, Princeton, NJ, USA.
28: Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Associated clinical trials:

Study of Nivolumab (BMS-936558) in Patients With Advanced or Metastatic Squamous Cell Nonsmall-cell Lung Cancer Who Have Received At Least 2 Prior Systemic Regimens | NCT01721759

Atezolizumab Immunotherapy in Patients With Advanced NSCLC | NCT03102242

Early Switch Maintenance vs Delayed Second-line Nivolumab in Advanced Stage Squamous Non-small Cell Lung Cancer (NSCLC) Patients (EDEN Trial) (EDEN) | NCT03542461

The Assessment of Immune Response in Newly Diagnosed Glioblastoma Patients Treated With Pembrolizumab (PIRG) | NCT05235737

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