Genomic diversity of colorectal cancer: Changing landscape and emerging targets.

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🔗 View Article (PMID 27433082)

Published in World J Gastroenterol on July 07, 2016

Authors

Daniel H Ahn1, Kristen K Ciombor1, Sameh Mikhail1, Tanios Bekaii-Saab1

Author Affiliations

1: Daniel H Ahn, Tanios Bekaii-Saab, Division of Medical Oncology, Mayo Clinic, Phoenix, AZ 85054, United States.

Associated clinical trials:

A Phase 1/2 Study to Evaluate MEDI4736 | NCT01693562

Phase 2 Study of MK-3475 in Patients With Microsatellite Unstable (MSI) Tumors | NCT01876511

A Phase 1 Study to Evaluate MEDI4736 in Combination With Tremelimumab | NCT01975831

A Study of Nivolumab and Nivolumab Plus Ipilimumab in Recurrent and Metastatic Colon Cancer (CheckMate 142) | NCT02060188

BRAF/MEK/EGFR Inhibitor Combination Study in Colorectal Cancer (CRC) | NCT01750918

An Open-label, Phase 2 Study of Neratinib in Patients With Solid Tumors With Somatic Human Epidermal Growth Factor Receptor (EGFR, HER2, HER3) Mutations or EGFR Gene Amplification | NCT01953926

Vaccine Therapy in Treating Patients With Metastatic Solid Tumors | NCT01376505

Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer | NCT01719380

S1406 Phase II Study of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF Mutant Metastatic Colorectal Cancer | NCT02164916

Phase 1b Trial of BGJ398/BYL719 in Solid Tumors | NCT01928459

A Phase 1 Trial of Vandetanib (a Multi-kinase Inhibitor of EGFR, VEGFR and RET Inhibitor) in Combination With Everolimus (an mTOR Inhibitor) in Advanced Cancer | NCT01582191

Phase Ib/II Study of Efficacy and Safety of MEK162 and Panitumumab, in Adult mCRC Patients With Mutant or Wild-type RAS Tumors | NCT01927341

Safety and Efficacy Study of Neratinib and Cetuximab to Treat Patients With Quadruple Wild-Type Metastatic Colorectal Cancer | NCT01960023

Study of Tivantinib (ARQ 197) Plus Cetuximab in EGFR Inhibitor-Resistant MET High Subjects | NCT01892527

Sorafenib or Crizotinib and Vemurafenib in Advanced Cancer | NCT01531361

Cabozantinib and Panitumumab to Treat KRAS Wild-Type Metastatic Colorectal Cancer (CaboMAb) | NCT02008383

MErCuRIC1: MEK and MET Inhibition in Colorectal Cancer (MErCuRIC1) | NCT02510001

Study of Pembrolizumab in Combination With Chemotherapy for Patients With Advanced Colorectal Cancer | NCT02375672

Ponatinib for Patients Whose Advanced Solid Tumor Cancer Has Activating Mutations Involving the Following Genes: FGFR1, FGFR2, FGFR3, FGFR4, RET, KIT. | NCT02272998

Study of RXDX-105 (RET and BRAF Inhibitor) in Patients With Advanced Solid Tumors | NCT01877811

Phase I/II Trial of Antagonism of HER in GI Cancer (PANTHER) | NCT01862003

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