Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27442016)

Published in PLoS One on July 21, 2016

Authors

Jingyue Xu1, Han Liu1, Ok Hee Chai1,2, Yu Lan3, Rulang Jiang1,4

Author Affiliations

1: Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States of America.
2: Department of Anatomy, Chonbuk National University Medical School and Institute for Medical Sciences, Deokjin-gu, Jeonju 561-756, Republic of Korea.
3: Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA Yu.Lan@cchmc.org.
4: Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States of America.

Articles cited by this

Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00

WT-1 is required for early kidney development. Cell (1993) 7.05

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature (2008) 7.03

Nephron number in patients with primary hypertension. N Engl J Med (2003) 6.74

Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature (1996) 4.37

Renal and neuronal abnormalities in mice lacking GDNF. Nature (1996) 4.06

Defects in enteric innervation and kidney development in mice lacking GDNF. Nature (1996) 3.82

Pax-2 controls multiple steps of urogenital development. Development (1995) 3.42

Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J (2006) 3.26

Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet (1999) 3.24

Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development (1990) 2.72

Six1 is required for the early organogenesis of mammalian kidney. Development (2003) 2.47

Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development (2001) 2.42

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor. Proc Natl Acad Sci U S A (1992) 2.42

SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A (2004) 2.41

SIX2 and BMP4 mutations associate with anomalous kidney development. J Am Soc Nephrol (2008) 2.30

The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo. Mech Dev (1993) 2.26

GDNF signalling through the Ret receptor tyrosine kinase. Nature (1996) 2.21

The many facets of the Wilms' tumour gene, WT1. Hum Mol Genet (2006) 2.10

Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev Biol (2008) 2.08

Human nephron number: implications for health and disease. Pediatr Nephrol (2011) 2.03

Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development. Development (1996) 1.96

Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development (2001) 1.84

Mammalian kidney development: principles, progress, and projections. Cold Spring Harb Perspect Biol (2012) 1.80

Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev Biol (1994) 1.71

Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development (2006) 1.69

Is there such a thing as a renal stem cell? J Am Soc Nephrol (2009) 1.61

Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc Natl Acad Sci U S A (1996) 1.58

Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development. Dev Biol (2005) 1.47

Renal-coloboma syndrome: report of a novel PAX2 gene mutation. Am J Ophthalmol (2001) 1.46

Primary renal hypoplasia in humans and mice with PAX2 mutations: evidence of increased apoptosis in fetal kidneys of Pax2(1Neu) +/- mutant mice. Hum Mol Genet (2000) 1.44

A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia. Mol Cell Biol (2004) 1.44

Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development. Mech Dev (2001) 1.38

Nephron number, renal function, and arterial pressure in aged GDNF heterozygous mice. Hypertension (2003) 1.37

The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor. FASEB J (1993) 1.31

Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev Genet (1999) 1.11

Nephron endowment in glial cell line-derived neurotrophic factor (GDNF) heterozygous mice. Kidney Int (2001) 1.08

WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors. Nat Commun (2014) 1.06

Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development (2014) 1.05

The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment. Cell Rep (2014) 1.03

The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Dev Cell (2013) 1.02

Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped. Mech Dev (1999) 1.01

Molecular regulation of nephron endowment. Am J Physiol (1999) 0.99

Genetics of renal hypoplasia: insights into the mechanisms controlling nephron endowment. Pediatr Res (2010) 0.98

A variant OSR1 allele which disturbs OSR1 mRNA expression in renal progenitor cells is associated with reduction of newborn kidney size and function. Hum Mol Genet (2011) 0.95

Branchio-oto-renal syndrome caused by partial EYA1 deletion due to LINE-1 insertion. Pediatr Nephrol (2010) 0.92

Renal-coloboma syndrome: prenatal detection and clinical spectrum in a large family. Am J Med Genet (2001) 0.88

Wilms' tumor-1: a riddle wrapped in a mystery, inside a kidney. Kidney Int (2008) 0.82

The OSR1 rs12329305 polymorphism contributes to the development of congenital malformations in cases of stillborn/neonatal death. Med Sci Monit (2014) 0.78