Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function.

PubWeight™: 0.87‹?›

🔗 View Article (PMID 27448090)

Published in Clin Pharmacol Ther on August 27, 2016

Authors

S Y Chang1, E J Weber2, Kp Van Ness2, D L Eaton1, E J Kelly3

Author Affiliations

1: Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, Washington, USA.
2: Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.
3: Department of Pharmaceutics, University of Washington, Seattle, Washington, USA. edkelly@uw.edu.

Articles citing this

Microphysiological Systems to Assess Nonclinical Toxicity. Curr Protoc Toxicol (2017) 0.75

Organ-on-a-chip for assessing environmental toxicants. Curr Opin Biotechnol (2017) 0.75

Articles cited by this

Clinical importance of the cytochromes P450. Lancet (2002) 3.77

HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int (1994) 3.60

Impact of OATP transporters on pharmacokinetics. Br J Pharmacol (2009) 2.97

Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97

Cytochromes P450 and metabolism of xenobiotics. Cell Mol Life Sci (2001) 2.54

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology (2006) 2.43

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology (2001) 2.36

Microengineered physiological biomimicry: organs-on-chips. Lab Chip (2012) 2.21

Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev (2011) 2.08

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab Dispos (2007) 1.97

Organs-on-chips at the frontiers of drug discovery. Nat Rev Drug Discov (2015) 1.95

Perfused multiwell plate for 3D liver tissue engineering. Lab Chip (2009) 1.88

Tissue culture of human kidney epithelial cells of proximal tubule origin. Kidney Int (1984) 1.76

An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture. Biotechnol Bioeng (2007) 1.75

The relevance and potential roles of microphysiological systems in biology and medicine. Exp Biol Med (Maywood) (2014) 1.74

Identification and characterization of a prostaglandin transporter. Science (1995) 1.65

A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab Chip (2010) 1.60

Formation of steady-state oxygen gradients in vitro: application to liver zonation. Biotechnol Bioeng (2003) 1.58

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab Chip (2009) 1.57

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity. Drug Metab Rev (2010) 1.52

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr Biol (Camb) (2013) 1.52

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. Toxicol Appl Pharmacol (2003) 1.49

Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure. Kidney Int (2004) 1.47

Organotypic liver culture models: meeting current challenges in toxicity testing. Crit Rev Toxicol (2012) 1.46

Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating. Drug Metab Dispos (2006) 1.38

Multi-cell type human liver microtissues for hepatotoxicity testing. Arch Toxicol (2012) 1.36

Tissue engineering of a bioartificial renal tubule assist device: in vitro transport and metabolic characteristics. Kidney Int (1999) 1.35

Structure and function of the human breast cancer resistance protein (BCRP/ABCG2). Curr Drug Metab (2010) 1.33

A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues. Drug Metab Dispos (2010) 1.26

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity. Toxicol Appl Pharmacol (2013) 1.25

Drug transport proteins in the liver. Adv Drug Deliv Rev (2003) 1.14

In vitro platforms for evaluating liver toxicity. Exp Biol Med (Maywood) (2014) 1.11

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes. Drug Metab Dispos (2011) 1.10

Biochemical characterization of renal epithelial cell cultures (LLC-PK1 and MDCK). Am J Physiol (1985) 1.09

OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids. Front Biosci (Landmark Ed) (2009) 1.05

In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. J Pharmacol Exp Ther (2001) 1.02

Proximal nephron. Compr Physiol (2013) 1.02

Physiology of cholangiocytes. Compr Physiol (2013) 1.00

A microfluidic hepatic coculture platform for cell-based drug metabolism studies. Biochem Pharmacol (2009) 0.99

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device. Xenobiotica (2014) 0.96

Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling. Toxicol Appl Pharmacol (2008) 0.96

Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies. Tissue Eng Part C Methods (2011) 0.94

Identification of proximal tubular transport functions in the established kidney cell line, OK. Biochim Biophys Acta (1987) 0.94

The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline. Stem Cell Res Ther (2013) 0.94

Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations. Sci Rep (2015) 0.93

The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule. Pflugers Arch (2012) 0.93

Differences in the expression of endogenous efflux transporters in MDR1-transfected versus wildtype cell lines affect P-glycoprotein mediated drug transport. Br J Pharmacol (2010) 0.93

A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Exp Biol Med (Maywood) (2015) 0.91

Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol (2005) 0.91

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans. Toxicol Sci (2012) 0.90

A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol (2015) 0.87

Morphological and biochemical integrity of human liver slices in long-term culture: effects of oxygen tension. Cell Biol Toxicol (2002) 0.87

Tissue engineering of a bioartificial renal tubule. ASAIO J (1998) 0.86

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife (2012) 0.85

Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system. Stem Cell Res Ther (2013) 0.85

Evaluation of bioartificial renal tubule device prepared with lifespan-extended human renal proximal tubular epithelial cells. Nephrol Dial Transplant (2012) 0.85

Uptake and efflux transporters for conjugates in human hepatocytes. Methods Enzymol (2005) 0.84

Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. Drug Metab Dispos (2015) 0.84

A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue. Exp Cell Res (2014) 0.84

Study of the transport of thyroid hormone by transporters of the SLC10 family. Mol Cell Endocrinol (2009) 0.84

Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol (2011) 0.84

Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac. Drug Metab Dispos (2013) 0.83

In vitro and in vivo models for assessing drug efflux transporter activity. Adv Drug Deliv Rev (2003) 0.83

Developing microphysiological systems for use as regulatory tools--challenges and opportunities. ALTEX (2014) 0.82

The paracellular permeability of opossum kidney cells, a proximal tubule cell line. Kidney Int (1999) 0.81

Pharmacokinetic profile that reduces nephrotoxicity of gentamicin in a perfused kidney-on-a-chip. Biofabrication (2016) 0.81

Autoimmune BSEP disease: disease recurrence after liver transplantation for progressive familial intrahepatic cholestasis. Clin Rev Allergy Immunol (2015) 0.79

A human in vitro model that mimics the renal proximal tubule. Tissue Eng Part C Methods (2014) 0.79

Transport of organic cations by kidney epithelial cell line LLC-PK1. J Pharmacol Exp Ther (1990) 0.78

Use of in vitro transporter assays to understand hepatic and renal disposition of new drug candidates. Expert Opin Drug Metab Toxicol (2005) 0.78

Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOC(TM)) System. Toxicol Res (2015) 0.78

Kidney derived micro-scaffolds enable HK-2 cells to develop more in-vivo like properties. Exp Cell Res (2014) 0.76

The bioartificial renal tubule: prospects to improve supportive care in acute renal failure. Ren Fail (1996) 0.76

Establishment of optimized MDCK cell lines for reliable efflux transport studies. J Pharm Sci (2014) 0.76

ABCB4: Insights from pathobiology into therapy. Clin Res Hepatol Gastroenterol (2014) 0.75