Published in Lab Chip on January 05, 2010
From 3D cell culture to organs-on-chips. Trends Cell Biol (2011) 2.83
Humanized mice with ectopic artificial liver tissues. Proc Natl Acad Sci U S A (2011) 2.03
Organs-on-chips at the frontiers of drug discovery. Nat Rev Drug Discov (2015) 1.95
Scaling and systems biology for integrating multiple organs-on-a-chip. Lab Chip (2013) 1.58
25th anniversary article: Rational design and applications of hydrogels in regenerative medicine. Adv Mater (2014) 1.52
Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip (2013) 1.50
Biomimetic tissues on a chip for drug discovery. Drug Discov Today (2011) 1.41
Accelerating drug discovery via organs-on-chips. Lab Chip (2013) 1.26
On being the right size: scaling effects in designing a human-on-a-chip. Integr Biol (Camb) (2013) 1.23
Engineering challenges for instrumenting and controlling integrated organ-on-chip systems. IEEE Trans Biomed Eng (2013) 1.21
Dissecting variability in responses to cancer chemotherapy through systems pharmacology. Clin Pharmacol Ther (2010) 1.11
Cell and tissue engineering for liver disease. Sci Transl Med (2014) 1.08
Bioreactor technologies to support liver function in vitro. Adv Drug Deliv Rev (2014) 1.05
Formation of microvascular networks in vitro. Nat Protoc (2013) 1.03
Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics. Biomicrofluidics (2011) 1.03
Review: toxicometabolomics. J Appl Toxicol (2013) 1.03
Approaching the in vitro clinical trial: engineering organs on chips. Lab Chip (2014) 0.98
Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure. Exp Biol Med (Maywood) (2014) 0.93
Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow. Lab Chip (2015) 0.92
Physiologically relevant organs on chips. Biotechnol J (2013) 0.91
μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips. PLoS One (2015) 0.90
Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system. Biomaterials (2012) 0.90
Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs. Sci Rep (2016) 0.89
A microfluidic platform for controlled biochemical stimulation of twin neuronal networks. Biomicrofluidics (2012) 0.88
Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function. Clin Pharmacol Ther (2016) 0.87
Pumpless microfluidic platform for drug testing on human skin equivalents. Lab Chip (2015) 0.86
Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration. CPT Pharmacometrics Syst Pharmacol (2015) 0.86
Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep (2017) 0.85
In vitro models of tumor vessels and matrix: engineering approaches to investigate transport limitations and drug delivery in cancer. Adv Drug Deliv Rev (2013) 0.85
Organ-on-a-chip and the kidney. Kidney Res Clin Pract (2015) 0.85
Microengineered tumor models: insights & opportunities from a physical sciences-oncology perspective. Biomed Microdevices (2013) 0.84
Microfluidics-assisted in vitro drug screening and carrier production. Adv Drug Deliv Rev (2013) 0.84
Encapsulation of Huh-7 cells within alginate-poly(ethylene glycol) hybrid microspheres. J Mater Sci Mater Med (2011) 0.83
Screening out irrelevant cell-based models of disease. Nat Rev Drug Discov (2016) 0.83
Endothelial Cell Vascular Smooth Muscle Cell Co-Culture Assay For High Throughput Screening Assays For Discovery of Anti-Angiogenesis Agents and Other Therapeutic Molecules. Int J High Throughput Screen (2010) 0.83
Microfluidics-based in vivo mimetic systems for the study of cellular biology. Acc Chem Res (2014) 0.82
Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays. Anal Bioanal Chem (2010) 0.82
Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective. Adv Mater (2013) 0.82
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering. Sensors (Basel) (2015) 0.82
HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease. Stem Cell Res Ther (2013) 0.81
New tools and new biology: recent miniaturized systems for molecular and cellular biology. Mol Cells (2013) 0.81
Deconstructing signaling in three dimensions. Biochemistry (2014) 0.81
Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies. Technology (Singap World Sci) (2015) 0.81
Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. Integr Biol (Camb) (2015) 0.80
Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges. EBioMedicine (2016) 0.80
Microphysiological systems and low-cost microfluidic platform with analytics. Stem Cell Res Ther (2013) 0.79
Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury. Biomed Res Int (2016) 0.78
Single-cell measurement of red blood cell oxygen affinity. Proc Natl Acad Sci U S A (2015) 0.78
Myelination and node of Ranvier formation on sensory neurons in a defined in vitro system. In Vitro Cell Dev Biol Anim (2013) 0.77
Well plate-based perfusion culture device for tissue and tumor microenvironment replication. Lab Chip (2015) 0.76
A Reversibly Sealed, Easy Access, Modular (SEAM) Microfluidic Architecture to Establish In Vitro Tissue Interfaces. PLoS One (2016) 0.76
Microfluidic platform for photodynamic therapy cytotoxicity analysis of nanoencapsulated indocyanine-type photosensitizers. Biomicrofluidics (2016) 0.76
Engineered Liver Platforms for Different Phases of Drug Development. Trends Biotechnol (2016) 0.75
Adding the 'heart' to hanging drop networks for microphysiological multi-tissue experiments. Lab Chip (2015) 0.75
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. ALTEX (2016) 0.75
Recent Progress of Microfluidics in Translational Applications. Adv Healthc Mater (2016) 0.75
A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control. Lab Chip (2016) 0.75
Emerging In Vitro Liver Technologies for Drug Metabolism and Inter-Organ Interactions. Tissue Eng Part B Rev (2016) 0.75
Solving medical problems with BioMEMS. IEEE Pulse (2011) 0.75
Integration concepts for multi-organ chips: how to maintain flexibility?! Future Sci OA (2017) 0.75
Building an experimental model of the human body with non-physiological parameters. Technology (Singap World Sci) (2017) 0.75
Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk. Biotechnol Bioeng (2017) 0.75
Microtechnology-Based Multi-Organ Models. Bioengineering (Basel) (2017) 0.75
A hydrogel-based microfluidic device for the studies of directed cell migration. Lab Chip (2007) 2.34
Integration of cell culture and microfabrication technology. Biotechnol Prog (2003) 1.86
A three-channel microfluidic device for generating static linear gradients and its application to the quantitative analysis of bacterial chemotaxis. Lab Chip (2005) 1.85
Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip (2013) 1.50
A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. Lab Chip (2009) 1.49
The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors. Biotechnol Prog (2004) 1.41
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
Engineered bacterial outer membrane vesicles with enhanced functionality. J Mol Biol (2008) 1.20
Development of a microscale cell culture analog to probe naphthalene toxicity. Biotechnol Prog (2004) 1.19
Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model. Lab Chip (2010) 1.16
Design optimization of nano-grating surface plasmon resonance sensors. Opt Express (2006) 1.14
Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies. Biotechnol Prog (2004) 1.09
Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity. Biotechnol Bioeng (2009) 1.08
Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability. J Nutr Biochem (2008) 1.07
Metacridamides A and B, macrocycles from conidia of the entomopathogenic fungus Metarhizium acridum. J Nat Prod (2012) 1.07
Oral exposure to polystyrene nanoparticles affects iron absorption. Nat Nanotechnol (2012) 1.05
Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury. Lab Chip (2014) 1.04
An endothelial and astrocyte co-culture model of the blood-brain barrier utilizing an ultra-thin, nanofabricated silicon nitride membrane. Lab Chip (2004) 1.02
A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers. Biotechnol Bioeng (2009) 0.96
Determination of spatial distributions of zinc and active biomass in microbial biofilms by two-photon laser scanning microscopy. Appl Environ Microbiol (2005) 0.94
Structural characterization of plant-derived hepatitis B surface antigen employed in oral immunization studies. Vaccine (2003) 0.94
Robust control of initiation of prokaryotic chromosome replication: essential considerations for a minimal cell. Biotechnol Bioeng (2004) 0.93
Prevention of air bubble formation in a microfluidic perfusion cell culture system using a microscale bubble trap. Biomed Microdevices (2009) 0.93
A genomically/chemically complete module for synthesis of lipid membrane in a minimal cell. Biotechnol Bioeng (2007) 0.93
Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow. Lab Chip (2015) 0.92
Effects of glial cells on electrode impedance recorded from neuralprosthetic devices in vitro. Ann Biomed Eng (2010) 0.92
Microtechnology for mimicking in vivo tissue environment. Ann Biomed Eng (2012) 0.91
Novel insect cell line capable of complex N-glycosylation and sialylation of recombinant proteins. Biotechnol Prog (2003) 0.91
Real-time fluorescence detection of multiple microscale cell culture analog devices in situ. Cytometry A (2007) 0.90
Evaluation of Mut+ and MutS Pichia pastoris phenotypes for high level extracellular scFv expression under feedback control of the methanol concentration. Biotechnol Prog (2006) 0.90
Murine in vitro model of the blood-brain barrier for evaluating drug transport. Eur J Pharm Sci (2010) 0.90
Effect of subculture and elicitation on instability of taxol production in Taxus sp. suspension cultures. Biotechnol Prog (2004) 0.89
Antibody-based surface plasmon resonance detection of intact viral pathogen. Biotechnol Bioeng (2006) 0.88
Effect of iron concentration on the growth rate of Pseudomonas syringae and the expression of virulence factors in hrp-inducing minimal medium. Appl Environ Microbiol (2009) 0.87
Fabrication of a multiple-diameter branched network of microvascular channels with semi-circular cross-sections using xenon difluoride etching. Biomed Microdevices (2008) 0.86
Pumpless microfluidic platform for drug testing on human skin equivalents. Lab Chip (2015) 0.86
Characterization of in vitro endothelial linings grown within microfluidic channels. Tissue Eng Part A (2011) 0.85
Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling. Expert Opin Drug Metab Toxicol (2010) 0.85
In vitro microscale systems for systematic drug toxicity study. Bioprocess Biosyst Eng (2009) 0.85
Surface-enhanced localized surface plasmon resonance biosensing of avian influenza DNA hybridization using subwavelength metallic nanoarrays. Nanotechnology (2010) 0.85
Effect of culture conditions on the degree of sialylation of a recombinant glycoprotein expressed in insect cells. Biotechnol Prog (2003) 0.84
Production of a sialylated N-linked glycoprotein in insect cells: role of glycosidases and effect of harvest time on glycosylation. Biotechnol Prog (2003) 0.83
Hepatitis B surface antigen (HBsAg) expression in plant cell culture: Kinetics of antigen accumulation in batch culture and its intracellular form. Biotechnol Bioeng (2002) 0.83
Development of a stable dual cell-line GFP expression system to study estrogenic endocrine disruptors. Biotechnol Bioeng (2008) 0.82
A combined pharmacokinetic-pharmacodynamic (PK-PD) model for tumor growth in the rat with UFT administration. J Pharm Sci (2009) 0.82
Spatial distributions of copper in microbial biofilms by scanning electrochemical microscopy. Environ Sci Technol (2007) 0.82
Optical measurement of neural activity using surface plasmon resonance. Opt Lett (2008) 0.81
Production, secretion, and stability of human secreted alkaline phosphatase in tobacco NT1 cell suspension cultures. Biotechnol Prog (2006) 0.81
Glycosylation profiles of the human colorectal cancer A33 antigen naturally expressed in the human colorectal cancer cell line SW1222 and expressed as recombinant protein in different insect cell lines. Biotechnol Prog (2004) 0.81
Effect of silkworm hemolymph on N-linked glycosylation in two Trichoplusia ni insect cell lines. Biotechnol Bioeng (2003) 0.81
Iron requirement for Mn(II) oxidation by Leptothrix discophora SS-1. Appl Environ Microbiol (2008) 0.80
Accelerating innovation between surgeons and biomedical engineers in the academic setting. Surgery (2008) 0.80
Promises, challenges and future directions of microCCAs. J Biotechnol (2010) 0.80
Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. Integr Biol (Camb) (2015) 0.80
Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices. Biotechnol Bioeng (2009) 0.79
Synthesis and characterization of high-throughput nanofabricated poly(4-hydroxy styrene) membranes for in vitro models of barrier tissue. Tissue Eng Part C Methods (2012) 0.79
Development of a gastrointestinal tract microscale cell culture analog to predict drug transport. Mol Cell Biomech (2008) 0.79
Molecular engineering of epoxide hydrolase and its application to asymmetric and enantioconvergent hydrolysis. Biotechnol Bioeng (2007) 0.79
Microphysiological systems and low-cost microfluidic platform with analytics. Stem Cell Res Ther (2013) 0.79
Macromolecular crowding can account for RNase-sensitive constraint of bacterial nucleoid structure. Biochem Biophys Res Commun (2010) 0.78
An uncertain role for Cu(II) in stimulating Mn(II) oxidation by Leptothrix discophora SS-1. Arch Microbiol (2010) 0.78
Relationship of viability and apoptosis to taxol production in Taxus sp. suspension cultures elicited with methyl jasmonate. Biotechnol Prog (2005) 0.78
Paclitaxel delivery to brain tumors from hydrogels: a computational study. Biotechnol Prog (2011) 0.78
Sensitivity and control analysis of periodically forced reaction networks using the Green's function method. J Theor Biol (2007) 0.78
Effect of oxide formation mechanisms on lead adsorption by biogenic manganese (hydr)oxides, iron (hydr)oxides, and their mixtures. Environ Sci Technol (2002) 0.78
The effect of astrocytes on the induction of barrier properties in aortic endothelial cells. Biotechnol Prog (2011) 0.77
Portable in situ fluorescence cytometry of microscale cell-based assays. Opt Lett (2005) 0.77
Complex responses to culture conditions in Pseudomonas syringae pv. tomato DC3000 continuous cultures: the role of iron in cell growth and virulence factor induction. Biotechnol Bioeng (2010) 0.77
Batch, fed-batch, and microcarrier cultures with CHO cell lines in a pressure-cycle driven miniaturized bioreactor. Biotechnol Bioeng (2011) 0.77
The effect of ajmalicine spiking and resin addition timing on the production of indole alkaloids from Catharanthus roseus cell cultures. Biotechnol Bioeng (2002) 0.77
Factors important in the extraction, stability and in vitro assembly of the hepatitis B surface antigen derived from recombinant plant systems. Biotechnol Prog (2002) 0.77
Development of disposable PDMS micro cell culture analog devices with photopolymerizable hydrogel encapsulating living cells. Biomed Microdevices (2012) 0.76
Mobilization of adsorbed copper and lead from naturally aged soil by bacterial extracellular polymers. Water Res (2004) 0.76
A self-priming microfluidic diaphragm pump capable of recirculation fabricated by combining soft lithography and traditional machining. Biotechnol Bioeng (2004) 0.76
Biomedical Technologies for in vitro Screening and Controlled Delivery of Neuroactive Compounds. Cent Nerv Syst Agents Med Chem (2008) 0.76
Quantification of chemical-polymer surface interactions in microfluidic cell culture devices. Biotechnol Prog (2009) 0.75
Solving medical problems with BioMEMS. IEEE Pulse (2011) 0.75
Predicting the rate and extent of cadmium and copper desorption from soils in the presence of bacterial extracellular polymer. Water Res (2004) 0.75
Effect of the plant peptide regulator, phytosulfokine-alpha, on the growth and Taxol production from Taxus sp. suspension cultures. Biotechnol Bioeng (2006) 0.75
Mini-scale bioprocessing systems for highly parallel animal cell cultures. Biotechnol Prog (2012) 0.75
Lipid-gel and poly(dimethylsiloxane) film to mimic bioaccumulation in adipocytes. Biotechnol Bioeng (2004) 0.75
Development of a model microbial predator-prey system suitable for studies of the behavior of toxic trace metals. Environ Toxicol Chem (2004) 0.75
Cloning, expression and enantioselective hydrolytic catalysis of a microsomal epoxide hydrolase from a marine fish, Mugil cephalus. Biotechnol Lett (2006) 0.75
The effect of various substrates on cell attachment and differentiation of 3T3-F442A preadipocytes. Biotechnol Bioeng (2002) 0.75
Alterations in Taxol production in plant cell culture via manipulation of the phenylalanine ammonia lyase pathway. Biotechnol Prog (2002) 0.75
Prediction of naphthalene bioaccumulation using an adipocyte cell line model. Biotechnol Prog (2002) 0.75
Influence of culture medium supplementation of tobacco NT1 cell suspension cultures on the N-glycosylation of human secreted alkaline phosphatase. Biotechnol Bioeng (2007) 0.75
Behavior of lead in a model microbial predator-prey system. Environ Toxicol Chem (2005) 0.75
Cell cycle progression in Escherichia coli B/r affects transcription of certain genes: Implications for synthetic genome design. Biotechnol Bioeng (2009) 0.75
Elmer L. Gaden, Jr. Tribute. Biotechnol Bioeng (2012) 0.75