Published in Integr Biol (Camb) on September 01, 2013
25th anniversary article: Rational design and applications of hydrogels in regenerative medicine. Adv Mater (2014) 1.52
A bioartificial renal tubule device embedding human renal stem/progenitor cells. PLoS One (2014) 1.45
Microfabrication of human organs-on-chips. Nat Protoc (2013) 1.44
Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells. J Am Soc Nephrol (2016) 1.37
Accelerating drug discovery via organs-on-chips. Lab Chip (2013) 1.26
Organ-on-a-chip platforms for studying drug delivery systems. J Control Release (2014) 1.06
From cardiac tissue engineering to heart-on-a-chip: beating challenges. Biomed Mater (2015) 0.94
Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations. Sci Rep (2015) 0.93
Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure. Exp Biol Med (Maywood) (2014) 0.93
Tissue-engineered kidney disease models. Adv Drug Deliv Rev (2013) 0.93
Development of a microphysiological model of human kidney proximal tubule function. Kidney Int (2016) 0.90
A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening. Exp Biol Med (Maywood) (2014) 0.89
Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function. Clin Pharmacol Ther (2016) 0.87
Mesenchymal Stromal Cells Epithelial Transition Induced by Renal Tubular Cells-Derived Extracellular Vesicles. PLoS One (2016) 0.86
Development of the Mammalian Kidney. Curr Top Dev Biol (2016) 0.86
Biomimetic 3D Tissue Models for Advanced High-Throughput Drug Screening. J Lab Autom (2014) 0.85
Organ-on-a-chip and the kidney. Kidney Res Clin Pract (2015) 0.85
The body-on-a-chip concept: possibilities and limitations. EXCLI J (2014) 0.84
Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology. Trends Pharmacol Sci (2015) 0.84
Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective. Adv Mater (2013) 0.82
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering. Sensors (Basel) (2015) 0.82
Microfluidic approaches for epithelial cell layer culture and characterisation. Analyst (2014) 0.81
Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips. Sci Rep (2016) 0.80
Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. Integr Biol (Camb) (2015) 0.80
Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges. EBioMedicine (2016) 0.80
In situ, dual-mode monitoring of organ-on-a-chip with smartphone-based fluorescence microscope. Biosens Bioelectron (2016) 0.80
Application of small RNA sequencing to identify microRNAs in acute kidney injury and fibrosis. Toxicol Appl Pharmacol (2015) 0.78
Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics. PLoS One (2015) 0.78
Self-organized Kidney Rudiments: Prospects for Better in vitro Nephrotoxicity Assays. Biomark Insights (2015) 0.77
Generating kidney tissue from pluripotent stem cells. Cell Death Discov (2016) 0.77
3D functional and perfusable microvascular networks for organotypic microfluidic models. J Mater Sci Mater Med (2015) 0.77
Organ-on-a-Chip: New Platform for Biological Analysis. Anal Chem Insights (2015) 0.76
Organ-on-chip models: new opportunities for biomedical research. Future Sci OA (2016) 0.75
Toxicity Minimized Cryoprotectant Addition and Removal Procedures for Adherent Endothelial Cells. PLoS One (2015) 0.75
High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures. Arch Toxicol (2015) 0.75
Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells. PLoS One (2015) 0.75
Microfluidics meets metabolomics to reveal the impact of Campylobacter jejuni infection on biochemical pathways. Biomed Microdevices (2016) 0.75
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. ALTEX (2016) 0.75
A Role for 3D Printing in Kidney-on-a-Chip Platforms. Curr Transplant Rep (2016) 0.75
3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing. Front Physiol (2017) 0.75
Nanomedicines for renal disease: current status and future applications. Nat Rev Nephrol (2016) 0.75
Recapitulation of microtissue models connected with real-time readout systems via 3D printing technology. J Thorac Dis (2017) 0.75
From Microscale Devices to 3D Printing: Advances in Fabrication of 3D Cardiovascular Tissues. Circ Res (2017) 0.75
A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells. Biomicrofluidics (2016) 0.75
Long-term ex vivo maintenance of testis tissues producing fertile sperm in a microfluidic device. Sci Rep (2016) 0.75
Priming nanoparticle-guided diagnostics and therapeutics towards human organs-on-chips microphysiological system. Nano Converg (2016) 0.75
Spatial Chemical Stimulation Control in Microenvironment by Microfluidic Probe Integrated Device for Cell-Based Assay. PLoS One (2016) 0.75
Microfluidic cell chips for high-throughput drug screening. Bioanalysis (2016) 0.75
Drug discovery in focal and segmental glomerulosclerosis. Kidney Int (2016) 0.75
Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy. Sci Rep (2016) 0.75
The bioengineered kidney: science or science fiction? Curr Opin Nephrol Hypertens (2016) 0.75
Tissue chips - innovative tools for drug development and disease modeling. Lab Chip (2017) 0.75
Vasculature-On-A-Chip for In Vitro Disease Models. Bioengineering (Basel) (2017) 0.75
Microfluidic on-chip biomimicry for 3D cell culture: a fit-for-purpose investigation from the end user standpoint. Future Sci OA (2017) 0.75
Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway. Mol Biol Cell (2017) 0.75
Microfluidics for Antibiotic Susceptibility and Toxicity Testing. Bioengineering (Basel) (2016) 0.75
Organ-on-a-chip for assessing environmental toxicants. Curr Opin Biotechnol (2017) 0.75
Cdc42 activation couples fluid shear stress to apical endocytosis in proximal tubule cells. Physiol Rep (2017) 0.75
The ascendance of microphysiological systems to solve the drug testing dilemma. Future Sci OA (2017) 0.75
Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Nat Biomed Eng (2017) 0.75
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature (2008) 7.60
Reconstituting organ-level lung functions on a chip. Science (2010) 5.75
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol (2009) 5.41
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J (2006) 4.06
Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett (2005) 3.90
Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol (2006) 3.63
Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J (2002) 3.45
A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature (2009) 3.44
Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science (2012) 3.33
Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation (2008) 3.33
Mechanical control of tissue and organ development. Development (2010) 3.18
Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci (2006) 2.98
Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics (2003) 2.92
From 3D cell culture to organs-on-chips. Trends Cell Biol (2011) 2.83
Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Commun (2003) 2.71
Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol (2006) 2.62
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med (2012) 2.52
Micropatterning tractional forces in living cells. Cell Motil Cytoskeleton (2002) 2.45
High-betweenness proteins in the yeast protein interaction network. J Biomed Biotechnol (2005) 2.44
Cell tension, matrix mechanics, and cancer development. Cancer Cell (2005) 2.42
Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE (2002) 2.36
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip (2012) 2.36
Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells. Lab Chip (2007) 2.30
Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. Proc Natl Acad Sci U S A (2009) 2.25
Nanomagnetic actuation of receptor-mediated signal transduction. Nat Nanotechnol (2007) 2.22
Microengineered physiological biomimicry: organs-on-chips. Lab Chip (2012) 2.21
Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Dev Dyn (2005) 2.13
Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells. Am J Physiol Cell Physiol (2003) 2.09
A flexible and highly sensitive strain-gauge sensor using reversible interlocking of nanofibres. Nat Mater (2012) 2.09
Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity. Neonatology (2013) 2.06
Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J Biol Chem (2004) 1.98
Combined microfluidic-micromagnetic separation of living cells in continuous flow. Biomed Microdevices (2006) 1.96
Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol (2006) 1.95
Self-assembly of three-dimensional prestressed tensegrity structures from DNA. Nat Nanotechnol (2010) 1.95
Micromagnetic-microfluidic blood cleansing device. Lab Chip (2009) 1.95
Geometric determinants of directional cell motility revealed using microcontact printing. Langmuir (2003) 1.85
TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res (2009) 1.84
Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev Cell (2011) 1.82
Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem (2007) 1.81
Mechanosensitive mechanisms in transcriptional regulation. J Cell Sci (2012) 1.76
Selective chemical treatment of cellular microdomains using multiple laminar streams. Chem Biol (2003) 1.74
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest (2011) 1.74
Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent. J Cell Sci (2006) 1.72
Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. FASEB J (2008) 1.71
Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress. Am J Physiol Cell Physiol (2004) 1.68
Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos (2003) 1.64
Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A (2008) 1.60
Paper-supported 3D cell culture for tissue-based bioassays. Proc Natl Acad Sci U S A (2009) 1.60
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins. J Cell Biol (2005) 1.59
Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem (2006) 1.58
A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab Chip (2009) 1.57
Multistable and multistep dynamics in neutrophil differentiation. BMC Cell Biol (2006) 1.56
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation. Integr Biol (Camb) (2013) 1.54
Mechanosensitivity of fibroblast cell shape and movement to anisotropic substratum topography gradients. Biomaterials (2009) 1.53
Noise-driven stem cell and progenitor population dynamics. PLoS One (2008) 1.52
Forty-year journey of angiogenesis translational research. Sci Transl Med (2011) 1.51
Synergistic effects of nanotopography and co-culture with endothelial cells on osteogenesis of mesenchymal stem cells. Biomaterials (2013) 1.51
Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J Cell Sci (2007) 1.51
A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks. Breast Dis (2007) 1.49
Mechanobiology and developmental control. Annu Rev Cell Dev Biol (2013) 1.48
Cytoskeletal control of growth and cell fate switching. Curr Opin Cell Biol (2009) 1.45
Microfabrication of human organs-on-chips. Nat Protoc (2013) 1.44
Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med (2010) 1.43
Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res (2004) 1.43
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. EMBO J (2002) 1.42
Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor. Mech Chem Biosyst (2005) 1.40
Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy. Adv Funct Mater (2009) 1.39
Micromechanical control of cell and tissue development: implications for tissue engineering. Adv Drug Deliv Rev (2007) 1.36
A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells. Lab Chip (2012) 1.35
ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem (2008) 1.34
Isolation and culture of primary human hepatocytes. Methods Mol Biol (2005) 1.34
Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos (2004) 1.32
Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochem Biophys Res Commun (2004) 1.29
Rheological behavior of living cells is timescale-dependent. Biophys J (2007) 1.29
Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A (2005) 1.28
Nanotopography-guided tissue engineering and regenerative medicine. Adv Drug Deliv Rev (2012) 1.28
Carbon metabolism-mediated myogenic differentiation. Nat Chem Biol (2010) 1.25
Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos Trans R Soc Lond B Biol Sci (2007) 1.24
Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb) (2010) 1.23
Towards a holistic, yet gene-centered analysis of gene expression profiles: a case study of human lung cancers. J Biomed Biotechnol (2006) 1.22
Lab-on-a-chip devices as an emerging platform for stem cell biology. Lab Chip (2010) 1.20
Synergistically enhanced osteogenic differentiation of human mesenchymal stem cells by culture on nanostructured surfaces with induction media. Biomacromolecules (2010) 1.18
Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol (2005) 1.17
Rho signaling and mechanical control of vascular development. Curr Opin Hematol (2008) 1.17
Engineered in vitro disease models. Annu Rev Pathol (2015) 1.16
Magnetically-guided self-assembly of fibrin matrices with ordered nano-scale structure for tissue engineering. Tissue Eng (2006) 1.13
Investigating complexity of protein-protein interactions in focal adhesions. Biochem Biophys Res Commun (2008) 1.11
Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. PLoS One (2008) 1.10
Caldesmon-dependent switching between capillary endothelial cell growth and apoptosis through modulation of cell shape and contractility. Angiogenesis (2003) 1.10
A computational tensegrity model predicts dynamic rheological behaviors in living cells. Ann Biomed Eng (2004) 1.09
A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis. Sci Signal (2012) 1.09
Multizone paper platform for 3D cell cultures. PLoS One (2011) 1.09
A discrete cell cycle checkpoint in late G(1) that is cytoskeleton-dependent and MAP kinase (Erk)-independent. Exp Cell Res (2002) 1.08
Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration. Integr Biol (Camb) (2012) 1.08
Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A (2013) 1.08