Published in Oncogene on July 25, 2016
Fast and accurate mutation detection in whole genome sequences of multiple isogenic samples with IsoMut. BMC Bioinformatics (2017) 0.76
Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes. Br J Cancer (2017) 0.75
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res (2010) 97.51
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13
Signatures of mutational processes in human cancer. Nature (2013) 21.63
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol (2000) 13.46
Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22
Genomic instability--an evolving hallmark of cancer. Nat Rev Mol Cell Biol (2010) 7.11
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75
CREST maps somatic structural variation in cancer genomes with base-pair resolution. Nat Methods (2011) 5.34
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell (2011) 4.41
BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group. J Clin Oncol (2012) 3.86
A model for replication repair in mammalian cells. J Mol Biol (1976) 3.78
PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol (2009) 3.15
Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. Nat Rev Cancer (2007) 3.02
Endogenous DNA damage in humans: a review of quantitative data. Mutagenesis (2004) 3.02
Human cancers express mutator phenotypes: origin, consequences and targeting. Nat Rev Cancer (2011) 2.77
Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction. EMBO J (1982) 2.67
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks. Nucleic Acids Res (2005) 2.44
A role for PCNA ubiquitination in immunoglobulin hypermutation. PLoS Biol (2006) 2.43
PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40. Mol Cell (2008) 2.29
Light chain gene conversion continues at high rate in an ALV-induced cell line. EMBO J (1990) 2.28
Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks. Chem Res Toxicol (2006) 2.25
Mutagenesis at methylated CpG sequences. Curr Top Microbiol Immunol (2006) 2.24
Repair of endogenous DNA damage. Cold Spring Harb Symp Quant Biol (2000) 2.24
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells. Proc Natl Acad Sci U S A (2011) 2.12
BRCA2: a universal recombinase regulator. Oncogene (2007) 1.96
Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation. Cancer Res (2012) 1.78
Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy. Cancer Discov (2015) 1.76
Subclonal diversification of primary breast cancer revealed by multiregion sequencing. Nat Med (2015) 1.74
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Cold Spring Harb Perspect Biol (2015) 1.73
RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. Cancer Res (2007) 1.68
SAMBLASTER: fast duplicate marking and structural variant read extraction. Bioinformatics (2014) 1.67
Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer. Br J Cancer (2012) 1.64
Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents. Cancer Discov (2012) 1.59
BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell (2011) 1.48
BRCA1-independent ubiquitination of FANCD2. Mol Cell (2003) 1.46
Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1. Mol Biol Cell (2010) 1.34
Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51. Nat Struct Mol Biol (2008) 1.26
BRCA1 haploinsufficiency for replication stress suppression in primary cells. Nat Commun (2014) 1.24
The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. PLoS Genet (2011) 1.21
Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40. Philos Trans R Soc Lond B Biol Sci (2001) 1.20
Role for RAD18 in homologous recombination in DT40 cells. Mol Cell Biol (2006) 1.19
Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2. Int J Cancer (2002) 1.16
REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo. Nucleic Acids Res (2008) 1.15
DNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage. Science (2015) 1.11
Ubiquitin family modifications and template switching. FEBS Lett (2011) 1.10
Translesion DNA synthesis and mutagenesis in eukaryotes. Cold Spring Harb Perspect Biol (2013) 1.09
Association of BRCA1/2 defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes. Breast Cancer Res (2014) 1.07
A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest. Nucleic Acids Res (2011) 1.06
The role of microhomology in genomic structural variation. Trends Genet (2014) 1.02
Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nat Commun (2015) 0.95
Cell cycle arrest at the initiation step of human chromosomal DNA replication causes DNA damage. J Cell Sci (2004) 0.93
DNA breaks and chromosomal aberrations arise when replication meets base excision repair. J Cell Biol (2014) 0.92
The genome of the chicken DT40 bursal lymphoma cell line. G3 (Bethesda) (2014) 0.84
Analysis of CPD ultraviolet lesion bypass in chicken DT40 cells: polymerase η and PCNA ubiquitylation play identical roles. PLoS One (2012) 0.79
Baseline sister chromatid exchange in human cell lines with different levels of poly(ADP-ribose) polymerase. Radiat Res (1991) 0.76
Fast and accurate mutation detection in whole genome sequences of multiple isogenic samples with IsoMut. BMC Bioinformatics (2017) 0.76
Sequenza: allele-specific copy number and mutation profiles from tumor sequencing data. Ann Oncol (2014) 2.08