Published in Mol Biol Cell on January 06, 2010
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. Nat Struct Mol Biol (2011) 2.42
Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress. Nucleic Acids Res (2012) 1.47
Replication stress and cancer: it takes two to tango. Exp Cell Res (2014) 1.33
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med (2012) 1.16
CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress. Oncogene (2014) 0.99
High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX. Cell Res (2015) 0.97
The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition. PLoS One (2012) 0.96
Persistent DNA damage after high dose in vivo gamma exposure of minipig skin. PLoS One (2012) 0.95
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity. Proc Natl Acad Sci U S A (2013) 0.94
H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues. Clin Epigenetics (2011) 0.94
Chk1 suppressed cell death. Cell Div (2010) 0.90
Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit. Cell Cycle (2013) 0.88
Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation. Proc Natl Acad Sci U S A (2013) 0.88
A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Autophagy (2014) 0.88
Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors. Oncogene (2014) 0.87
HUWE1 interacts with PCNA to alleviate replication stress. EMBO Rep (2016) 0.86
Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage. J Biol Chem (2014) 0.85
Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy. Oncotarget (2014) 0.84
The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels. Stem Cell Res (2012) 0.84
PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors. Cell Death Differ (2014) 0.83
Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons. Nat Commun (2014) 0.82
Dual effect of heat shock on DNA replication and genome integrity. Mol Biol Cell (2012) 0.81
DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B. Cell Death Dis (2014) 0.81
Characterization of the role of Fhit in suppression of DNA damage. Adv Biol Regul (2012) 0.79
Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients. Oncogene (2015) 0.79
Rad51 in regulating the radiosensitivity of non-small cell lung cancer with different epidermal growth factor receptor mutation status. Thorac Cancer (2015) 0.78
Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors. J Immunol (2016) 0.78
siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors. Oncogene (2013) 0.78
E1a promotes c-Myc-dependent replicative stress: implications in glioblastoma radiosensitization. Cell Cycle (2013) 0.77
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities. Cell Rep (2015) 0.77
Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions. Oncogene (2016) 0.77
Genomic instability in liver cells caused by an LPS-induced bystander-like effect. PLoS One (2013) 0.76
Evaluation of surrogate tissues as indicators of drug activity in a melanoma skin model. Cancer Med (2016) 0.75
Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells. Nucleic Acids Res (2015) 0.75
Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress. Stem Cell Res Ther (2016) 0.75
Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication. J Clin Invest (2017) 0.75
Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry. Cell Cycle (2016) 0.75
Heat-shock induced γH2AX foci are associated with the nuclear matrix only in S-phase cells. Dokl Biochem Biophys (2013) 0.75
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13
The DNA damage response: putting checkpoints in perspective. Nature (2000) 19.07
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81
p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol (2000) 13.46
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
GammaH2AX and cancer. Nat Rev Cancer (2008) 9.77
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem (2001) 7.35
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol (2005) 4.62
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol (2005) 4.54
Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem (2000) 4.36
Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell (2006) 3.62
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J Biol Chem (2003) 3.45
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J Cell Biol (2001) 3.35
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell (2008) 3.15
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol Biol Cell (2005) 3.08
H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc Natl Acad Sci U S A (2006) 2.85
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. EMBO J (2003) 2.76
ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci U S A (2001) 2.75
Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO J (2007) 2.44
Control of sister chromatid recombination by histone H2AX. Mol Cell (2004) 2.43
gammaH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS One (2007) 2.07
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol (2004) 1.82
Human MRE11 is inactivated in mismatch repair-deficient cancers. EMBO Rep (2002) 1.80
The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Res (2003) 1.70
H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation. Mol Cancer Ther (2007) 1.69
Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell (2005) 1.60
Chk1 is essential for tumor cell viability following activation of the replication checkpoint. Cell Cycle (2005) 1.59
ATM is required for the cellular response to thymidine induced replication fork stress. Hum Mol Genet (2004) 1.46
ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet (2009) 1.43
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev (2009) 1.42
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem (2006) 1.36
The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. Nucleic Acids Res (2009) 1.35
A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. Mol Biol Cell (2008) 1.34
A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. Oncogene (2005) 1.32
Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase. Genes Cells (2007) 1.20
p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. Oncogene (2006) 1.15
Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45. Cell Death Differ (2008) 0.99
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature (2005) 19.13
Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol Cell Biol (2002) 2.73
Association of a common variant of the CASP8 gene with reduced risk of breast cancer. J Natl Cancer Inst (2004) 2.66
FGFR3 mutations indicate better survival in invasive upper urinary tract and bladder tumours. Eur Urol (2008) 2.65
Distinct microRNA alterations characterize high- and low-grade bladder cancer. Cancer Res (2009) 2.58
Promoter hypermethylation is associated with tumor location, stage, and subsequent progression in transitional cell carcinoma. J Clin Oncol (2005) 2.45
Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell (2005) 1.60
Multifocal urothelial cancers with the mutator phenotype are of monoclonal origin and require panurothelial treatment for tumor clearance. J Urol (2006) 1.54
ATM is required for the cellular response to thymidine induced replication fork stress. Hum Mol Genet (2004) 1.46
Distinct patterns of microsatellite instability are seen in tumours of the urinary tract. Oncogene (2003) 1.43
ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet (2009) 1.43
A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer. Hum Mol Genet (2002) 1.40
A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. Mol Biol Cell (2008) 1.34
Promoter hypermethylation identifies progression risk in bladder cancer. Clin Cancer Res (2007) 1.32
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Nucleic Acids Res (2009) 1.30
Molecular detection of localized prostate cancer using quantitative methylation-specific PCR on urinary cells obtained following prostate massage. Clin Cancer Res (2007) 1.23
Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines. Hum Mol Genet (2002) 1.19
Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress. Stem Cells (2012) 1.02
Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11. Clin Cancer Res (2008) 1.00
Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks. Nucleic Acids Res (2009) 1.00
Promoter hypermethylation in circulating blood cells identifies prostate cancer progression. Int J Cancer (2008) 0.98
Deficient DNA damage response and cell cycle checkpoints lead to accumulation of point mutations in human embryonic stem cells. Stem Cells (2012) 0.98
A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks. Hum Mol Genet (2003) 0.92
Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3. Carcinogenesis (2003) 0.92
Clinically localised prostate cancer is microsatellite stable. BJU Int (2007) 0.89
Vincristine regulates the phosphorylation of the antiapoptotic protein HSP27 in breast cancer cells. Cancer Lett (2006) 0.88
Treatment with the Chk1 inhibitor Gö6976 enhances cisplatin cytotoxicity in SCLC cells. Int J Oncol (2011) 0.85
Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability. Int J Cancer (2003) 0.81
Suppression of apoptosis by PIF1 helicase in human tumor cells. Cancer Res (2011) 0.81
Characterization of HSP27 phosphorylation induced by microtubule interfering agents: implication of p38 signalling pathway. Arch Biochem Biophys (2007) 0.80
Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest. J Proteomics (2008) 0.78
A naturally occurring mutation in an ATP-binding domain of the recombination repair gene XRCC3 ablates its function without causing cancer susceptibility. Hum Mol Genet (2003) 0.77
Phosphorylation of human eukaryotic elongation factor 1Bgamma is regulated by paclitaxel. Proteomics (2007) 0.75