Published in J Neurosurg Anesthesiol on August 25, 2016
Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology (2009) 9.51
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci (2003) 7.42
Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology (2010) 4.44
Cognitive and behavioral outcomes after early exposure to anesthesia and surgery. Pediatrics (2011) 3.76
Anesthesia-induced developmental neuroapoptosis. Does it happen in humans? Anesthesiology (2004) 3.22
Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a sibling birth cohort. Anesth Analg (2011) 3.08
Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways. Neuroscience (2005) 2.52
Sedative and anticonvulsant drugs suppress postnatal neurogenesis. Ann Neurol (2008) 2.46
Comparison of the neuroapoptotic properties of equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in neonatal mice. Anesthesiology (2011) 2.42
Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex. Anesth Analg (2013) 2.41
Neurotoxicity of generic anesthesia agents in infants and children: an orphan research question in search of a sponsor. JAMA (2015) 2.19
Modeling transformations of neurodevelopmental sequences across mammalian species. J Neurosci (2013) 1.99
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement (2016) 1.93
Isoflurane-induced neuroapoptosis in the developing brain of nonhypoglycemic mice. J Neurosurg Anesthesiol (2008) 1.80
What are biomarkers? Curr Opin HIV AIDS (2010) 1.80
The mitochondrial pathway of anesthetic isoflurane-induced apoptosis. J Biol Chem (2009) 1.64
Anesthetic neurotoxicity--clinical implications of animal models. N Engl J Med (2015) 1.49
Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics. Acta Neurochir (Wien) (2009) 1.38
Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain. Ann N Y Acad Sci (2010) 1.37
General anesthetics and the developing brain. Curr Opin Anaesthesiol (2009) 1.28
Early exposure to general anesthesia disturbs mitochondrial fission and fusion in the developing rat brain. Anesthesiology (2013) 1.11
Biomarkers for the clinical differential diagnosis in traumatic brain injury--a systematic review. CNS Neurosci Ther (2013) 1.09
Anesthetic neurotoxicity. Anesthesiol Clin (2013) 1.08
Cognition and Brain Structure Following Early Childhood Surgery With Anesthesia. Pediatrics (2015) 1.08
Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway. Anesth Analg (2013) 1.03
Cell age-specific vulnerability of neurons to anesthetic toxicity. Ann Neurol (2013) 1.00
Effect of ketamine on dendritic arbor development and survival of immature GABAergic neurons in vitro. Toxicol Sci (2006) 0.95
Metabolomic profiling of children's brains undergoing general anesthesia with sevoflurane and propofol. Anesthesiology (2012) 0.91
The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns. Best Pract Res Clin Anaesthesiol (2010) 0.89
Mechanistic insights into neurotoxicity induced by anesthetics in the developing brain. Int J Mol Sci (2012) 0.87
Effects of isoflurane or propofol on postnatal hippocampal neurogenesis in young and aged rats. Brain Res (2013) 0.86
Cerebellar neurometabolite abnormalities in pediatric attention/deficit hyperactivity disorder: a proton MR spectroscopic study. Neurosci Lett (2009) 0.85
Preclinical research into the effects of anesthetics on the developing brain: promises and pitfalls. J Neurosurg Anesthesiol (2012) 0.85
Genetic and environmental factors in complex neurodevelopmental disorders. Curr Genomics (2007) 0.84
1H MRSI of middle frontal gyrus in pediatric ADHD. J Psychiatr Res (2012) 0.84
Anesthetic neurotoxicity in the newborn and infant. Curr Opin Anaesthesiol (2013) 0.83
General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus. Anesthesiology (2016) 0.80
The power of using functional fMRI on small rodents to study brain pharmacology and disease. Front Pharmacol (2015) 0.80
MR imaging-detectable metabolic alterations in attention deficit/hyperactivity disorder: from preclinical to clinical studies. AJNR Am J Neuroradiol (2014) 0.78
α-Lipoic acid inhibits sevoflurane-induced neuronal apoptosis through PI3K/Akt signalling pathway. Cell Biochem Funct (2016) 0.77
Glial Fibrillary Acidic Protein Is Not an Early Marker of Injury in Perinatal Asphyxia and Hypoxic-Ischemic Encephalopathy. Front Neurol (2015) 0.76
Bayesian Inference for Functional Dynamics Exploring in fMRI Data. Comput Math Methods Med (2016) 0.76
Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. Environ Health Perspect (2007) 3.33
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest (2011) 2.99
Comparison of the neuroapoptotic properties of equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in neonatal mice. Anesthesiology (2011) 2.42
Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex. Anesth Analg (2013) 2.41
Apoptotic neuronal death following deep hypothermic circulatory arrest in piglets. Anesthesiology (2003) 2.15
Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology (2011) 1.88
Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets. Anesth Analg (2009) 1.82
Cardiac conduction through engineered tissue. Am J Pathol (2006) 1.80
Congenital supravalvular aortic stenosis and sudden death associated with anesthesia: what's the mystery? Anesth Analg (2008) 1.72
Blood transfusion after pediatric cardiac surgery is associated with prolonged hospital stay. Ann Thorac Surg (2011) 1.71
Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med (2012) 1.65
Cardiac arrest after neuromuscular blockade reversal in a heart transplant infant. Anesthesiology (2007) 1.61
Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland. Environ Sci Technol (2007) 1.59
Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro. Am J Physiol Heart Circ Physiol (2005) 1.57
Cardiovascular causes of airway compression. Paediatr Anaesth (2004) 1.56
Prenatal bisphenol a exposure and child behavior in an inner-city cohort. Environ Health Perspect (2012) 1.50
Endogenous angiogenesis inhibitors prevent adaptive capillary growth in left ventricular pressure overload hypertrophy. Ann Thorac Surg (2012) 1.49
Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation. Arterioscler Thromb Vasc Biol (2003) 1.49
Isoflurane preconditioning uncouples mitochondria and protects against hypoxia-reoxygenation. Am J Physiol Cell Physiol (2007) 1.45
High Glucose Attenuates Anesthetic Cardioprotection in Stem-Cell-Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission. Anesth Analg (2016) 1.38
2007 in review: a dozen steps forward in Anesthesiology. Anesthesiology (2008) 1.38
Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors. BMC Dev Biol (2010) 1.33
Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest (2009) 1.32
General anesthetics and the developing brain. Curr Opin Anaesthesiol (2009) 1.28
Heterogeneous integration of adult-generated granule cells into the epileptic brain. J Neurosci (2011) 1.26
Anesthetic-induced preconditioning delays opening of mitochondrial permeability transition pore via protein Kinase C-epsilon-mediated pathway. Anesthesiology (2009) 1.26
The relationship between inflammatory activation and clinical outcome after infant cardiopulmonary bypass. Anesth Analg (2010) 1.23
Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy. Hippocampus (2010) 1.21
The frequency of anesthesia-related cardiac arrests in patients with congenital heart disease undergoing cardiac surgery. Anesth Analg (2007) 1.20
The safety, efficacy, and pharmacokinetics of esmolol for blood pressure control immediately after repair of coarctation of the aorta in infants and children: a multicenter, double-blind, randomized trial. J Thorac Cardiovasc Surg (2008) 1.18
Vascular endothelial growth factor prevents apoptosis and preserves contractile function in hypertrophied infant heart. Circulation (2006) 1.17
Promoting angiogenesis protects severely hypertrophied hearts from ischemic injury. Ann Thorac Surg (2004) 1.17
Laparoscopic surgery in a patient with Fontan physiology. Anesth Analg (2006) 1.16
The incidence and implications of anti-heparin-platelet factor 4 antibody formation in a pediatric cardiac surgical population. Anesth Analg (2008) 1.15
Beyond anesthetic properties: the effects of isoflurane on brain cell death, neurogenesis, and long-term neurocognitive function. Anesth Analg (2010) 1.13
Volatile anesthetic-induced cardiac preconditioning. J Anesth (2007) 1.12
Loss of T-type calcium current in sensory neurons of rats with neuropathic pain. Anesthesiology (2003) 1.12
Differences in production of reactive oxygen species and mitochondrial uncoupling as events in the preconditioning signaling cascade between desflurane and sevoflurane. Anesth Analg (2009) 1.10
Distinct roles for sarcolemmal and mitochondrial adenosine triphosphate-sensitive potassium channels in isoflurane-induced protection against oxidative stress. Anesthesiology (2006) 1.10
A word of caution: dexmedetomidine and pulmonary hypertension. Anesth Analg (2014) 1.08
Analysis of surgical outcome in complex double-outlet right ventricle with heterotaxy syndrome or complete atrioventricular canal defect. Ann Thorac Surg (2006) 1.08
Muscle engraftment of myogenic progenitor cells following intraarterial transplantation. Muscle Nerve (2006) 1.06
Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. Anesthesiology (2005) 1.05
Delayed cardioprotection by isoflurane: role of K(ATP) channels. Am J Physiol Heart Circ Physiol (2002) 1.04
Mitochondrial depolarization underlies delay in permeability transition by preconditioning with isoflurane: roles of ROS and Ca2+. Am J Physiol Cell Physiol (2010) 1.03
Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway. Anesth Analg (2013) 1.03
Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning. Anesthesiology (2011) 1.02
Emerging technology in molecular epidemiology: what epidemiologists need to know. Epidemiology (2008) 1.02
Procoagulant and anticoagulant factor abnormalities following the Fontan procedure: increased factor VIII may predispose to thrombosis. J Thorac Cardiovasc Surg (2003) 1.02
Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm. Anesthesiology (2009) 1.01
Isoflurane preconditioning elicits competent endogenous mechanisms of protection from oxidative stress in cardiomyocytes derived from human embryonic stem cells. Anesthesiology (2010) 1.01
Cell age-specific vulnerability of neurons to anesthetic toxicity. Ann Neurol (2013) 1.00
Chronic upper airway obstruction and cardiac dysfunction: anatomy, pathophysiology and anesthetic implications. Paediatr Anaesth (2004) 0.99
miR-21 contributes to xenon-conferred amelioration of renal ischemia-reperfusion injury in mice. Anesthesiology (2013) 0.99
Dopamine treatment of postischemic contractile dysfunction rapidly induces calcium-dependent pro-apoptotic signaling. Circulation (2002) 0.98
Coagulation abnormalities in patients with single-ventricle physiology precede the Fontan procedure. J Thorac Cardiovasc Surg (2002) 0.97
Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. PLoS One (2009) 0.96
Noninvasive serial evaluation of myocardial mechanics in pressure overload hypertrophy of rabbit myocardium. Herz (2003) 0.96
Monitoring mitochondrial electron fluxes using NAD(P)H-flavoprotein fluorometry reveals complex action of isoflurane on cardiomyocytes. Biochim Biophys Acta (2010) 0.95
Development of left ventricular diastolic dysfunction with preservation of ejection fraction during progression of infant right ventricular hypertrophy. Circ Heart Fail (2009) 0.95
Successful use of bivalirudin for cardiac transplantation in a child with heparin-induced thrombocytopenia. J Heart Lung Transplant (2006) 0.94
Reactive oxygen species precede the epsilon isoform of protein kinase C in the anesthetic preconditioning signaling cascade. Anesthesiology (2003) 0.94
Prospective longitudinal study of coagulation profiles in children with hypoplastic left heart syndrome from stage I through Fontan completion. J Thorac Cardiovasc Surg (2009) 0.93
Coagulation factor abnormalities in patients with single-ventricle physiology immediately prior to the Fontan procedure. Ann Thorac Surg (2002) 0.93
Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery. J Thorac Cardiovasc Surg (2011) 0.93
The perioperative management of a patient with complex single ventricle physiology and pheochromocytoma. Anesth Analg (2005) 0.93
Impaired insulin-signaling in hypertrophied hearts contributes to ischemic injury. Biochem Biophys Res Commun (2005) 0.93
CXCR4 enhances engraftment of muscle progenitor cells. Muscle Nerve (2009) 0.92
Preconditioning by isoflurane induces lasting sensitization of the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel by a protein kinase C-delta-mediated mechanism. Anesthesiology (2005) 0.92
Clinical research into anesthetic neurotoxicity: does anesthesia cause neurological abnormalities in humans? J Neurosurg Anesthesiol (2014) 0.92
Anesthetic-related neurotoxicity in the developing infant: of mice, rats, monkeys and, possibly, humans. Anesth Analg (2008) 0.92
Low-level lead exposure and elevations in blood pressure during pregnancy. Environ Health Perspect (2011) 0.91
Xenon preconditioning: the role of prosurvival signaling, mitochondrial permeability transition and bioenergetics in rats. Anesth Analg (2009) 0.91
Cytosolic calcium in the ischemic rabbit heart: assessment by pH- and temperature-adjusted rhod-2 spectrofluorometry. Cardiovasc Res (2003) 0.91
Age-related attenuation of isoflurane preconditioning in human atrial cardiomyocytes: roles for mitochondrial respiration and sarcolemmal adenosine triphosphate-sensitive potassium channel activity. Anesthesiology (2008) 0.91
Marked hyperglycemia attenuates anesthetic preconditioning in human-induced pluripotent stem cell-derived cardiomyocytes. Anesthesiology (2012) 0.90
Feasibility and pilot study of the Pediatric Anesthesia NeuroDevelopment Assessment (PANDA) project. J Neurosurg Anesthesiol (2012) 0.90
Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers. Anesth Analg (2007) 0.90
Chromosomal substitution-dependent differences in cardiovascular responses to sodium pentobarbital. Anesth Analg (2006) 0.89
The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns. Best Pract Res Clin Anaesthesiol (2010) 0.89
Abnormalities of granule cell dendritic structure are a prominent feature of the intrahippocampal kainic acid model of epilepsy despite reduced postinjury neurogenesis. Epilepsia (2012) 0.89
Detection of carbon monoxide during routine anesthetics in infants and children. Anesth Analg (2010) 0.88
Protein kinase C-epsilon primes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to modulation by isoflurane. Anesthesiology (2004) 0.88
Cyclosporin A but not FK-506 protects against dopamine-induced apoptosis in the stunned heart. Ann Thorac Surg (2005) 0.88
Patient and procedural characteristics for successful and failed immediate tracheal extubation in the operating room following cardiac surgery in infancy. Paediatr Anaesth (2014) 0.88
Reversal of minimum alveolar concentrations of volatile anesthetics by chromosomal substitution. Anesthesiology (2004) 0.87
Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. Circulation (2002) 0.87
Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett (2010) 0.86
Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity. Anesthesiology (2016) 0.86
Electron transport chain dysfunction in neonatal pressure-overload hypertrophy precedes cardiomyocyte apoptosis independent of oxidative stress. J Thorac Cardiovasc Surg (2009) 0.86
CON: The toxic effects of anesthetics in the developing brain: the clinical perspective. Anesth Analg (2008) 0.86
Transcriptomic and proteomic analysis of global ischemia and cardioprotection in the rabbit heart. Physiol Genomics (2009) 0.86
Short history of just mentorship and support. Croat Med J (2008) 0.85
Myocyte apoptosis occurs early during the development of pressure-overload hypertrophy in infant myocardium. J Thorac Cardiovasc Surg (2009) 0.85
Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway, and chromosome 13-substituted consomic rat strains: role of large conductance Ca2+ and voltage-activated potassium channels. J Pharmacol Exp Ther (2009) 0.85
Comparison of cardiomyogenic potential among human ESC and iPSC lines. Cell Transplant (2012) 0.85
Preclinical research into the effects of anesthetics on the developing brain: promises and pitfalls. J Neurosurg Anesthesiol (2012) 0.85
Down-regulation of microRNA-21 is involved in the propofol-induced neurotoxicity observed in human stem cell-derived neurons. Anesthesiology (2014) 0.84
In vitro remifentanil metabolism: the effects of whole blood constituents and plasma butyrylcholinesterase. Anesth Analg (2002) 0.84