Wnt5a Signaling in Cancer.

PI3Kα isoform-dependent activation of RhoA regulates Wnt5a-induced osteosarcoma cell migration. Cancer Cell Int (2017) 0.75

Clinical applications of mouse models for breast cancer engaging HER2/neu. Integr Cancer Sci Ther (2016) 0.75

EZH2 is involved in silencing of WNT5A during epithelial-mesenchymal transition of colon cancer cell line. J Cancer Res Clin Oncol (2017) 0.75

Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One (2017) 0.75

Wnt5a Signaling in Normal and Cancer Stem Cells. Stem Cells Int (2017) 0.75

Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen. Oncotarget (2017) 0.75

Hallmarks of cancer: the next generation. Cell (2011) 140.01

Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82

On the origin of cancer cells. Science (1956) 49.55

Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17

A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89

Cell migration: integrating signals from front to back. Science (2003) 29.13

mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16

Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55

The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol (2006) 11.16

Wnt signalling and its impact on development and cancer. Nat Rev Cancer (2008) 8.37

The essence of senescence. Genes Dev (2010) 8.21

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36

Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell (2009) 7.09

Towards an integrated view of Wnt signaling in development. Development (2009) 6.07

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell (2002) 5.23

The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells (2003) 4.11

Prognostic factors for stage III epithelial ovarian cancer: a Gynecologic Oncology Group Study. J Clin Oncol (2007) 4.06

The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet (2000) 3.91

JNK phosphorylates paxillin and regulates cell migration. Nature (2003) 3.60

The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem (2007) 3.24

Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler Thromb Vasc Biol (2008) 3.13

Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06

Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J Cell Biol (1996) 3.01

Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J Biol Chem (2000) 2.90

Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res (2006) 2.86

Wnt5a functions in planar cell polarity regulation in mice. Dev Biol (2007) 2.85

Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A. Dev Biol (1997) 2.66

Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc Natl Acad Sci U S A (2006) 2.60

Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell (2003) 2.49

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood (2006) 2.33

Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science (2008) 2.22

SnapShot: Noncanonical Wnt Signaling Pathways. Cell (2007) 2.14

The brain tumor microenvironment. Glia (2011) 2.13

Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene (2005) 2.11

The opposing roles of Wnt-5a in cancer. Br J Cancer (2009) 2.07

Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J (2009) 1.97

Senescence, apoptosis and therapy--cutting the lifelines of cancer. Nat Rev Cancer (2003) 1.91

Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell (2015) 1.90

Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. Dev Cell (2011) 1.83

Wnt signaling in stem and cancer stem cells. Semin Cell Dev Biol (2010) 1.79

The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene (2009) 1.75

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Rep (2013) 1.74

Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase. Oncogene (2010) 1.68

Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration. J Cell Biol (2006) 1.67

Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor--an expression in non-small-cell lung cancer. J Clin Oncol (2005) 1.67

WNT5A expression increases during melanoma progression and correlates with outcome. Clin Cancer Res (2008) 1.50

Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheum (2001) 1.46

A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell (2014) 1.44

Wnt signalling and the control of cellular metabolism. Biochem J (2010) 1.42

Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res (2008) 1.41

A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J Biol Chem (2005) 1.32

Wnt5A activates the calpain-mediated cleavage of filamin A. J Invest Dermatol (2009) 1.32

Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res (2009) 1.29

P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: current status and future perspectives. Curr Cancer Drug Targets (2013) 1.29

Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res (2011) 1.29

A novel role for Wnt/Ca2+ signaling in actin cytoskeleton remodeling and cell motility in prostate cancer. PLoS One (2010) 1.26

Senescence: a new weapon for cancer therapy. Trends Cell Biol (2012) 1.25

A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci U S A (2009) 1.25

Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development. Dev Genes Evol (2001) 1.22

A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling. J Biol Chem (1997) 1.21

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. J Clin Invest (2014) 1.16

The WNT signaling pathway from ligand secretion to gene transcription: molecular mechanisms and pharmacological targets. Pharmacol Ther (2013) 1.14

Canonical and noncanonical Wnt pathway: a comparison among normal ovary, benign ovarian tumor and ovarian cancer. Oncol Rep (2009) 1.13

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way. Glia (2010) 1.13

WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma. Cancer Biol Ther (2010) 1.12

Mechanism-based cancer therapy: resistance to therapy, therapy for resistance. Oncogene (2014) 1.10

Senescence induction; a possible cancer therapy. Mol Cancer (2009) 1.10

The small GTPase ARF6 stimulates β-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis. Sci Signal (2013) 1.10

Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway. Cancer Lett (2012) 1.05

WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol Cancer (2014) 1.05

Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment. Biochem J (2011) 1.05

Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer. Int J Gynecol Cancer (2011) 1.05

Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells. Cancer Res (2015) 1.04

Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy. Proc Natl Acad Sci U S A (2014) 1.04

ROR1 expression correlated with poor clinical outcome in human ovarian cancer. Sci Rep (2014) 1.04

The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration. Cancer Res (2013) 1.03

Role of Wnt5a in the proliferation of human glioblastoma cells. Cancer Lett (2007) 1.01

A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells. PLoS One (2011) 1.01

Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins. Mod Pathol (2009) 1.01

Wnt5a promotes human colon cancer cell migration and invasion but does not augment intestinal tumorigenesis in Apc1638N mice. Carcinogenesis (2013) 1.00

The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours. J Pathol (2002) 0.99

Wnt5a induces a tolerogenic phenotype of macrophages in sepsis and breast cancer patients. J Immunol (2012) 0.99

Gene expression profiling of a clonal isolate of oxaliplatin-resistant ovarian carcinoma cell line A2780/C10. Oncol Rep (2005) 0.98

An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis. Mol Cancer Ther (2011) 0.96

WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer. Neoplasia (2013) 0.96

Wnt5a suppresses colon cancer by inhibiting cell proliferation and epithelial-mesenchymal transition. J Cell Physiol (2014) 0.95

SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling. Mol Cell Biol (2013) 0.93

Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein. J Biol Chem (2012) 0.93

Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 induction. Br J Cancer (2014) 0.92

Activation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathways. J Biol Chem (2013) 0.92

Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway. Oncotarget (2014) 0.91

Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively. Sci Rep (2015) 0.90

WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis. Oncotarget (2015) 0.89

Wnt5a promotes vasculogenic mimicry and epithelial-mesenchymal transition via protein kinase Cα in epithelial ovarian cancer. Oncol Rep (2014) 0.89

Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells. Pigment Cell Melanoma Res (2014) 0.89

WNT5A encodes two isoforms with distinct functions in cancers. PLoS One (2013) 0.87

Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation. J Neuroinflammation (2012) 0.86

Cancer stem cells, cancer-initiating cells and methods for their detection. Drug Discov Today (2016) 0.86

Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma. J Biol Chem (2015) 0.84