Published in Mol Med Rep on August 19, 2016
Mechanisms of angiogenesis and arteriogenesis. Nat Med (2000) 13.88
Metals, toxicity and oxidative stress. Curr Med Chem (2005) 7.48
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell (2009) 5.33
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29
Angiogenesis: a team effort coordinated by notch. Dev Cell (2009) 4.05
Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature (2010) 3.54
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest (2015) 2.93
Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer (2010) 2.93
Genetics of ischaemic stroke. Lancet Neurol (2007) 2.75
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci (2009) 2.74
Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc Res (2003) 2.61
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol (2004) 2.59
Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev Cell (2011) 2.17
Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res (2005) 2.16
Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J Biol Chem (2003) 2.02
Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem (1999) 2.00
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol (2014) 1.98
Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest (2008) 1.89
Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med (2006) 1.82
Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev (2002) 1.80
Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Front Biosci (Landmark Ed) (2009) 1.76
Oxidative stress in the context of acute cerebrovascular stroke. Stroke (2000) 1.68
Notch signaling is activated by TLR stimulation and regulates macrophage functions. Eur J Immunol (2008) 1.68
Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling. J Cell Biochem (2007) 1.67
The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. J Biol Chem (2003) 1.66
Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells. PLoS One (2008) 1.66
Thyroid diseases and cerebrovascular disease. Stroke (2005) 1.63
Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia. Am J Physiol Heart Circ Physiol (2008) 1.61
Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A (2010) 1.61
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J (2002) 1.57
Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms. Circulation (2009) 1.57
Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways. Cell Signal (2013) 1.56
VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis. Br J Cancer (2008) 1.55
Extracellular redox state: refining the definition of oxidative stress in aging. Rejuvenation Res (2006) 1.55
Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochem Biophys (2001) 1.52
Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. PLoS One (2014) 1.52
Notch signaling in astrocytes and neuroblasts of the adult subventricular zone in health and after cortical injury. Dev Neurosci (2006) 1.48
CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia. Brain Pathol (2002) 1.43
Galectins in cell growth and apoptosis. Cell Mol Life Sci (2003) 1.41
Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS One (2007) 1.41
New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage. Nat Cell Biol (2001) 1.40
Arteriogenesis Versus Angiogenesis: Two Mechanisms of Vessel Growth. News Physiol Sci (1999) 1.40
Notch1 upregulates LPS-induced macrophage activation by increasing NF-kappaB activity. Eur J Immunol (2009) 1.39
MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma. PLoS One (2011) 1.38
Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis. Circ Res (2011) 1.37
Reactive oxygen species and oxidative DNA damage. Indian J Physiol Pharmacol (1998) 1.36
Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharm Res (1996) 1.35
Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ Res (2011) 1.34
R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways. J Mol Med (Berl) (2008) 1.33
Neuronal oxidative stress in acute ischemic stroke: sources and contribution to cell injury. Neurochem Int (2012) 1.30
Angiopoietin-1/Tie2 receptor signaling in vascular quiescence and angiogenesis. Histol Histopathol (2010) 1.27
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A (2012) 1.26
Notch signaling: direct or what? Curr Opin Genet Dev (1998) 1.23
Stroke in China. Clin Exp Pharmacol Physiol (2009) 1.22
Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma. Hepatology (2003) 1.21
Notch-induced rat and human bone marrow stromal cell grafts reduce ischemic cell loss and ameliorate behavioral deficits in chronic stroke animals. Stem Cells Dev (2009) 1.18
Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann N Y Acad Sci (2001) 1.17
Vascular endothelial growth factor (VEGF) and VEGF-C show overlapping binding sites in embryonic endothelia and distinct sites in differentiated adult endothelia. Circ Res (1999) 1.17
Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. J Neuropathol Exp Neurol (1998) 1.17
Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye. Curr Biol (2001) 1.17
A review of the current research on the role of bFGF and VEGF in angiogenesis. J Wound Care (2009) 1.17
Molecular regulation of the VEGF family -- inducers of angiogenesis and lymphangiogenesis. APMIS (2004) 1.16
Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease. Gene Ther (2001) 1.16
Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system. Ann N Y Acad Sci (1997) 1.14
Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS Neurol Disord Drug Targets (2013) 1.14
Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways. Histol Histopathol (2011) 1.13
Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo. PLoS One (2013) 1.13
Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury. Mol Neurobiol (2014) 1.12
Cortical neuronal apoptosis in CADASIL. Stroke (2006) 1.11
Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J Immunol (2006) 1.11
Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia. Circ Res (2010) 1.10
Microglia release activators of neuronal proliferation mediated by activation of mitogen-activated protein kinase, phosphatidylinositol-3-kinase/Akt and delta-Notch signalling cascades. J Neurochem (2004) 1.10
ERK1/2 is an endogenous negative regulator of the gamma-secretase activity. FASEB J (2005) 1.09
Silencing Notch-1 induces apoptosis and increases the chemosensitivity of prostate cancer cells to docetaxel through Bcl-2 and Bax. Oncol Lett (2012) 1.09
Emerging strategies to overcome the resistance to current mTOR inhibitors in renal cell carcinoma. Biochim Biophys Acta (2014) 1.09
Free radicals, antioxidant defense systems, and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry (2013) 1.08
Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature. Proc Natl Acad Sci U S A (2007) 1.07
Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines. Leuk Res (2008) 1.06
CADASIL: a critical look at a Notch disease. Dev Neurosci (2006) 1.06
Differential Notch and TGFbeta signaling in primary colorectal tumors and their corresponding metastases. Cell Oncol (2008) 1.06
miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia. Mol Cell Biochem (2012) 1.06
Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke. Mol Pharmacol (2011) 1.04
TGF-β receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy. Curr Pharm Biotechnol (2011) 1.04
Proliferating reactive astrocytes are regulated by Notch-1 in the peri-infarct area after stroke. Stroke (2011) 1.03
Tumor necrosis factor-alpha and apoptosis signal-regulating kinase 1 control reactive oxygen species release, mitochondrial autophagy, and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis. Oxid Med Cell Longev (2010) 1.03
Distinct Notch signaling outputs pattern the developing arterial system. Development (2014) 1.02
Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. J Biol Chem (2013) 1.02
Notch3 establishes brain vascular integrity by regulating pericyte number. Development (2013) 1.02
Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk. J Cell Sci (2007) 1.01
Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia. Stroke (2011) 1.01
Promoting angiogenesis via manipulation of VEGF responsiveness with notch signaling. Biomaterials (2009) 1.00
Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells. Microvasc Res (2000) 1.00
Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. Stroke (2008) 1.00
Notch signaling modulates the activation of microglial cells. Glia (2007) 0.99
Formation of the collateral circulation is regulated by vascular endothelial growth factor-A and a disintegrin and metalloprotease family members 10 and 17. Circ Res (2012) 0.99
Evaluation of oxidative stress in patients with acute ischemic stroke. Rom J Intern Med (2013) 0.99
Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1. Leukemia (2013) 0.98