Published in Chin J Cancer Res on August 01, 2016
TOR signaling in growth and metabolism. Cell (2006) 35.29
p53 mutations in human cancers. Science (1991) 31.96
Oxidants, oxidative stress and the biology of ageing. Nature (2000) 23.21
Cell death: critical control points. Cell (2004) 22.56
Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol (2006) 21.58
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science (1997) 15.25
Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 14.41
Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell (1993) 10.83
Mitochondrial formation of reactive oxygen species. J Physiol (2003) 10.73
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell (2006) 10.10
Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet (2005) 7.15
Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res (1991) 6.99
Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis (2000) 5.78
Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ (1999) 5.35
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal (2007) 5.17
Physiological roles of mitochondrial reactive oxygen species. Mol Cell (2012) 5.05
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science (1993) 4.53
Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics (2003) 3.84
Cytochrome c release from mitochondria proceeds by a two-step process. Proc Natl Acad Sci U S A (2002) 3.57
Mitochondria and neuronal survival. Physiol Rev (2000) 3.56
Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol (2000) 3.13
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A (2010) 3.03
NADPH oxidases in cardiovascular health and disease. Antioxid Redox Signal (2006) 2.95
Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif (1991) 2.81
VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol (2001) 2.80
Programmed cell death and Bcl-2 protection in very low oxygen. Nature (1995) 2.76
Reactive oxygen species in tumor progression. Front Biosci (2005) 2.72
Oxidative stress and apoptosis. Pathophysiology (2000) 2.58
Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J Biol Chem (1998) 2.51
Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature (1995) 2.40
Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J (2009) 2.35
Role of the mitochondrial membrane permeability transition in cell death. Apoptosis (2007) 2.33
Protein kinase C signaling and oxidative stress. Free Radic Biol Med (2000) 2.29
Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? Ann N Y Acad Sci (2000) 2.25
Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci (2007) 2.25
Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem (2002) 2.20
Cancer cell killing via ROS: to increase or decrease, that is the question. Cancer Biol Ther (2008) 2.07
Bioenergetic aspects of apoptosis, necrosis and mitoptosis. Apoptosis (2006) 2.06
Biological roles for the NOX family NADPH oxidases. J Biol Chem (2008) 1.96
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Invited review: manganese superoxide dismutase in disease. Free Radic Res (2001) 1.85
Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation. Apoptosis (2007) 1.73
Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents. Blood (2003) 1.72
Cytochrome P450 monooxygenases: an update on perspectives for synthetic application. Trends Biotechnol (2011) 1.71
Modulation of oxidant and antioxidant enzyme expression and function in vascular cells. Hypertension (2004) 1.69
Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine. Free Radic Biol Med (2004) 1.68
AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells. J Cell Mol Med (2009) 1.67
Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice. Cancer Res (2008) 1.63
N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc Natl Acad Sci U S A (1994) 1.60
Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. Free Radic Biol Med (2009) 1.54
Hypersensitization of tumor cells to glycolytic inhibitors. Biochemistry (2001) 1.52
Oxidative stress inhibits apoptosis in human lymphoma cells. J Biol Chem (1999) 1.51
Reactive oxygen species-dependent signaling regulates cancer. Cell Mol Life Sci (2009) 1.49
p53: 25 years after its discovery. Trends Pharmacol Sci (2004) 1.49
Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species. J Biol Chem (2002) 1.47
Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth. Aging Cell (2008) 1.47
Liver fatty acid-binding protein targets fatty acids to the nucleus. Real time confocal and multiphoton fluorescence imaging in living cells. J Biol Chem (2002) 1.47
Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways. J Immunol (2001) 1.46
Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Proc Natl Acad Sci U S A (2006) 1.42
Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry. Cancer Res (2004) 1.41
2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radic Biol Med (2007) 1.40
Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal (2012) 1.37
2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Res (2003) 1.34
Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway. Am J Physiol Lung Cell Mol Physiol (2005) 1.34
tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak. Cell Death Differ (2005) 1.33
Aerosolized administration of N-acetylcysteine attenuates lung fibrosis induced by bleomycin in mice. Am J Respir Crit Care Med (2000) 1.33
Recent advances in p53 research and cancer treatment. J Biomed Biotechnol (2011) 1.31
Regulation of apoptosis by the redox state of cytochrome c. Biochim Biophys Acta (2008) 1.31
Apoptosis in human disease: a new skin for the old ceremony? Biochem Biophys Res Commun (1999) 1.28
Melatonin mitigates mitochondrial malfunction. J Pineal Res (2005) 1.27
Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells. J Biol Chem (2000) 1.26
Vitamin C and cancer revisited. Proc Natl Acad Sci U S A (2008) 1.24
A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo. J Pharmacol Exp Ther (2003) 1.23
Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide. Life Sci (2005) 1.20
Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E). Circ Res (2000) 1.19
Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis (2002) 1.18
Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. Biochem Biophys Res Commun (2005) 1.18
Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions. Blood (2013) 1.18
Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment. Int Immunopharmacol (2004) 1.17
Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis? Cell Death Differ (2006) 1.16
The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive. Mol Cell Biochem (2002) 1.15
Photoprotective potential of lycopene, beta-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free Radic Biol Med (2002) 1.15
Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C). Biochem Pharmacol (2002) 1.15
Suppression of the pro-apoptotic function of cytochrome c by singlet oxygen via a haem redox state-independent mechanism. Biochem J (2005) 1.15
Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases. Oncogene (1998) 1.12
Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L. Cell Death Differ (2007) 1.11
Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis. Life Sci (2003) 1.10
Oxidative stress-induced apoptosis prevented by Trolox. Free Radic Biol Med (1994) 1.09
Differential sensitivity of cancer cells to docosahexaenoic acid-induced cytotoxicity: the potential importance of down-regulation of superoxide dismutase 1 expression. Mol Cancer Ther (2004) 1.08
Sensitization by docosahexaenoic acid (DHA) of breast cancer cells to anthracyclines through loss of glutathione peroxidase (GPx1) response. Free Radic Biol Med (2008) 1.06
Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys (2005) 1.06
Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 beta phosphorylation. Mol Cancer Ther (2008) 1.05
Rhein induces apoptosis in HL-60 cells via reactive oxygen species-independent mitochondrial death pathway. Arch Biochem Biophys (2003) 1.05
Withaferin A synergizes the therapeutic effect of doxorubicin through ROS-mediated autophagy in ovarian cancer. PLoS One (2012) 1.03
Endoplasmic reticulum stress triggers ROS signalling, changes the redox state, and regulates the antioxidant defence of Arabidopsis thaliana. J Exp Bot (2014) 1.03