p53: 25 years after its discovery.

Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR. J Immunol (2005) 2.83

Mutational spectra of human cancer. Hum Genet (2009) 2.26

Genetics of hepatocellular carcinoma. World J Gastroenterol (2007) 1.64

Cytotoxic Activities of Physalis minima L. Chloroform Extract on Human Lung Adenocarcinoma NCI-H23 Cell Lines by Induction of Apoptosis. Evid Based Complement Alternat Med (2011) 1.63

TP53 mutations in nonsmall cell lung cancer. J Biomed Biotechnol (2011) 1.46

The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. Cancer Res (2005) 1.42

A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol (2009) 1.28

A pivotal role for p53: balancing aerobic respiration and glycolysis. J Bioenerg Biomembr (2007) 1.21

Radiation metabolomics and its potential in biodosimetry. Int J Radiat Biol (2011) 1.20

Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells. Mol Cancer Ther (2006) 1.13

ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway. J Biol Chem (2008) 1.10

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. EMBO J (2006) 1.10

Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme. PLoS One (2011) 1.10

Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells. Cancer Res (2006) 1.05

Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies. Mol Cancer Res (2008) 1.05

Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships. J Med Chem (2011) 1.03

American ginseng suppresses colitis through p53-mediated apoptosis of inflammatory cells. Cancer Prev Res (Phila) (2010) 1.01

Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes. Clin Interv Aging (2008) 0.99

The importance of p53 pathway genetics in inherited and somatic cancer genomes. Nat Rev Cancer (2016) 0.98

Tumor suppression by p53: making cells senescent. Histol Histopathol (2010) 0.96

Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer. Trends Pharmacol Sci (2011) 0.94

Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing. FASEB J (2010) 0.94

Redundancy of DNA helicases in p53-mediated apoptosis. Oncogene (2006) 0.90

Adding pharmacogenomics to the development of new marine-derived anticancer agents. J Transl Med (2006) 0.90

Biochemical and functional evidence of p53 homology is inconsistent with molecular phylogenetics for distant sequences. J Mol Evol (2008) 0.88

Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure. Toxicol Appl Pharmacol (2009) 0.88

Elevated p53 and lower MDM2 expression in hippocampus from patients with intractable temporal lobe epilepsy. Epilepsy Res (2007) 0.87

Targeting tumor suppressor networks for cancer therapeutics. Curr Drug Targets (2014) 0.87

Mustard gas exposure and carcinogenesis of lung. Mutat Res (2009) 0.86

Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population. World J Gastroenterol (2005) 0.85

Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk. Oncotarget (2014) 0.84

T-2 toxin-induced apoptosis involving Fas, p53, Bcl-xL, Bcl-2, Bax and caspase-3 signaling pathways in human chondrocytes. J Zhejiang Univ Sci B (2008) 0.84

SN50 enhances the effects of LY294002 on cell death induction in gastric cancer cell line SGC7901. Arch Med Sci (2013) 0.84

Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells. World J Gastroenterol (2008) 0.82

Lowly expressed ribosomal protein s19 in the feces of patients with colorectal cancer. ISRN Gastroenterol (2012) 0.80

The role of p53 in cancer drug resistance and targeted chemotherapy. Oncotarget (2016) 0.79

Mutant p53 protein expression and antioxidant status deficiency in breast cancer. EXCLI J (2014) 0.79

Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53. World J Gastroenterol (2014) 0.78

Unveiling the methylation status of CpG dinucleotides in the substituted segment of the human p53 knock-in (Hupki) mouse genome. Mol Carcinog (2010) 0.78

SUMOylation of mouse p53b by SUMO-1 promotes its pro-apoptotic function in ovarian granulosa cells. PLoS One (2013) 0.78

C1, a highly potent novel curcumin derivative, binds to tubulin, disrupts microtubule network and induces apoptosis. Biosci Rep (2016) 0.77

Efficacy of recombinant adenoviral human p53 gene in the treatment of lung cancer-mediated pleural effusion. Oncol Lett (2015) 0.77

Noise amplification in human tumor suppression following gamma irradiation. PLoS One (2011) 0.76

Overproduction of reactive oxygen species - obligatory or not for induction of apoptosis by anticancer drugs. Chin J Cancer Res (2016) 0.75

Polymorphism of p53 in cancer prognosis. Indian J Med Res (2016) 0.75

The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated resistant glioma cell lines. Anticancer Res (2015) 0.75

Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness. Int J Mol Sci (2016) 0.75

Transcriptome Differences in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs in Response to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection. Int J Mol Sci (2017) 0.75

A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell (2006) 23.59

The IARC TP53 database: new online mutation analysis and recommendations to users. Hum Mutat (2002) 12.39

MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA (2008) 12.26

Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer (2010) 7.39

Radical causes of cancer. Nat Rev Cancer (2003) 5.45

KIF5B-RET fusions in lung adenocarcinoma. Nat Med (2012) 4.38

Inflammation and cancer: an ancient link with novel potentials. Int J Cancer (2007) 4.19

Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci U S A (2009) 3.64

Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol (2010) 3.49

Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis (2009) 3.40

The landscape of recombination in African Americans. Nature (2011) 3.06

MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival. Clin Cancer Res (2009) 3.03

p53: traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Cell Biol (2005) 2.78

The chemical biology of nitric oxide: implications in cellular signaling. Free Radic Biol Med (2008) 2.72

Reprogramming of miRNA networks in cancer and leukemia. Genome Res (2010) 2.65

Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer. J Natl Cancer Inst (2011) 2.61

Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One (2011) 2.57

p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence. Nat Cell Biol (2009) 2.46

Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res (2008) 2.45

p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res (2003) 2.40

Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China. Hepatology (2002) 2.38

TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer. IARC Sci Publ (2004) 2.23

TP53 and liver carcinogenesis. Hum Mutat (2003) 2.23

p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis. Cancer Res (2004) 2.08

p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol (2008) 2.04

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci U S A (2002) 2.04

BLM heterozygosity and the risk of colorectal cancer. Science (2002) 2.03

Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer. Int J Cancer (2011) 2.02

Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. Cancer Res (2003) 1.97

Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS One (2009) 1.94

MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma. Cancer Res (2010) 1.89

Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proc Natl Acad Sci U S A (2004) 1.87

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell (2013) 1.86

Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation. Cancer Res (2005) 1.86

Advances in chemical carcinogenesis: a historical review and prospective. Cancer Res (2008) 1.83

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol (2004) 1.82

The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J Clin Invest (2003) 1.82

POT1 and TRF2 cooperate to maintain telomeric integrity. Mol Cell Biol (2005) 1.74

BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. EMBO J (2003) 1.71

Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer. Clin Cancer Res (2005) 1.70

Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling. PLoS Genet (2013) 1.69

Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma. Clin Cancer Res (2009) 1.67

Microenvironmental modulation of asymmetric cell division in human lung cancer cells. Proc Natl Acad Sci U S A (2010) 1.66

Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res (2003) 1.64

Clinical outcomes and correlates of TP53 mutations and cancer. Cold Spring Harb Perspect Biol (2010) 1.64

The rectal cancer microRNAome--microRNA expression in rectal cancer and matched normal mucosa. Clin Cancer Res (2012) 1.61

Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis (2005) 1.61

Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier. J Natl Cancer Inst (2007) 1.58

Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles. Cancer Res (2002) 1.53

Telomere recombination requires the MUS81 endonuclease. Nat Cell Biol (2009) 1.45

Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo. Cancer Res (2004) 1.45

Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type. Mol Cell Proteomics (2008) 1.44

Lung cancer in never smokers: molecular profiles and therapeutic implications. Clin Cancer Res (2009) 1.44

The role of microRNAs in colorectal cancer. Cancer J (2012) 1.44

The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. Cancer Res (2005) 1.42

A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. Oncogene (2003) 1.40

WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res (2009) 1.39

Molecular pathogenesis of human hepatocellular carcinoma. Toxicology (2002) 1.35

p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene (2004) 1.33

Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling. Cancer Res (2006) 1.33

p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination. Cancer Res (2003) 1.32

Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Clin Cancer Res (2013) 1.31

ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Mol Cell Biol (2005) 1.31

Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls. Carcinogenesis (2003) 1.31

DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma. PLoS One (2012) 1.30

The association of microRNA expression with prognosis and progression in early-stage, non-small cell lung adenocarcinoma: a retrospective analysis of three cohorts. Clin Cancer Res (2011) 1.29

Nitric oxide in cancer and chemoprevention. Free Radic Biol Med (2003) 1.29

Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. J Biol Chem (2006) 1.28

Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma. Gastroenterology (2010) 1.28

Circulating microRNA expression profiles associated with systemic lupus erythematosus. Arthritis Rheum (2013) 1.28

Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21. Cancer Res (2011) 1.27

Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. Carcinogenesis (2004) 1.25

ING1 represses transcription by direct DNA binding and through effects on p53. Cancer Res (2003) 1.25

Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis. Int J Cancer (2006) 1.23

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22

Detection of HPV DNA in esophageal cancer specimens from different regions and ethnic groups: a descriptive study. BMC Cancer (2010) 1.22

Superoxide fluxes limit nitric oxide-induced signaling. J Biol Chem (2006) 1.22

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J Clin Invest (2013) 1.21

Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum Pathol (2004) 1.20

Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1. Cancer Res (2007) 1.19

Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Res (2008) 1.19

Alterations of microRNAs contribute to colon carcinogenesis. Semin Oncol (2011) 1.19

Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers. Clin Cancer Res (2012) 1.18

Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Res (2004) 1.15

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. Nat Cell Biol (2010) 1.14

Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A (2012) 1.13

The role of p53 in base excision repair following genotoxic stress. Carcinogenesis (2003) 1.13