Published in J Biol Chem on October 04, 2016
Re-Examining Neutrophil Participation in GN. J Am Soc Nephrol (2017) 0.75
Neutrophil extracellular traps kill bacteria. Science (2004) 23.64
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest (1973) 17.56
NADPH oxidase: an update. Blood (1999) 7.65
Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol (2011) 6.96
How neutrophils kill microbes. Annu Rev Immunol (2005) 6.87
Granules of the human neutrophilic polymorphonuclear leukocyte. Blood (1997) 5.07
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol (2010) 4.50
Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation (2003) 4.36
Neutrophils in development of multiple organ failure in sepsis. Lancet (2006) 3.64
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest (2004) 3.63
Neutrophil function: from mechanisms to disease. Annu Rev Immunol (2012) 3.63
A mutation in Rab27a causes the vesicle transport defects observed in ashen mice. Proc Natl Acad Sci U S A (2000) 3.07
Phagocytes and oxidative stress. Am J Med (2000) 3.00
Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation (2004) 2.79
Drugging the undruggable RAS: Mission possible? Nat Rev Drug Discov (2014) 2.77
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J Biol Chem (2002) 2.69
Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. Proc Natl Acad Sci U S A (1999) 2.40
Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol (2010) 2.09
Measurement of O2- production by human neutrophils. The preparation and assay of NADPH oxidase-containing particles from human neutrophils. Methods Enzymol (1984) 1.97
A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites. J Clin Invest (2006) 1.92
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. J Biol Chem (2001) 1.86
Phagocytosis by neutrophils. Microbes Infect (2003) 1.65
Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in fatal sepsis. J Lab Clin Med (1992) 1.65
Cutting edge: an endogenous pathway to systemic inflammatory response syndrome (SIRS)-like reactions through Toll-like receptor 4. J Immunol (2004) 1.62
Neutrophil plasma membranes. I. High-yield purification of human neutrophil plasma membrane vesicles by nitrogen cavitation and differential centrifugation. J Cell Biol (1980) 1.52
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Traffic (2008) 1.38
Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic (2009) 1.35
Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a. Structure (2008) 1.33
Proteases and lung injury. Crit Care Med (2003) 1.27
Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis. Intern Med (2010) 1.25
The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules. Traffic (2008) 1.22
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1. Proc Natl Acad Sci U S A (2011) 1.18
Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils. J Immunol (1999) 1.18
Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochem J (2007) 1.17
The actin cytoskeleton regulates exocytosis of all neutrophil granule subsets. Am J Physiol Cell Physiol (2007) 1.16
Chronic granulomatous disease. Semin Hematol (1990) 1.15
Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.14
JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. J Biol Chem (2001) 1.14
Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol (2008) 1.12
Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action. J Biomol Screen (2009) 1.12
Location of the epitope for 7D5, a monoclonal antibody raised against human flavocytochrome b558, to the extracellular peptide portion of primate gp91phox. Microbiol Immunol (2001) 1.08
Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst. J Immunol (2011) 1.08
Bioactivation of drugs: risk and drug design. Annu Rev Pharmacol Toxicol (2011) 1.07
Myeloperoxidase and oxidative stress in rheumatoid arthritis. Rheumatology (Oxford) (2012) 1.05
The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines. J Cell Sci (2008) 1.05
DNase I inhibits a late phase of reactive oxygen species production in neutrophils. J Innate Immun (2009) 1.04
Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis. J Crit Care (2010) 1.03
CD66b regulates adhesion and activation of human eosinophils. J Immunol (2007) 1.02
The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells. Proc Natl Acad Sci U S A (2002) 1.00
Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein. Mol Biol Cell (2012) 0.98
Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent. FEBS Lett (1999) 0.98
Inhibition of neutrophil exocytosis ameliorates acute lung injury in rats. Shock (2013) 0.97
Cathepsin g is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys. Am J Pathol (2007) 0.96
MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils. J Biol Chem (2012) 0.96
Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation. Infect Immun (2011) 0.92
Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation. Traffic (2005) 0.91
Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis. Mol Cell Biol (2013) 0.88
Interaction of myeloperoxidase with vascular NAD(P)H oxidase-derived reactive oxygen species in vasculature: implications for vascular diseases. Am J Physiol Heart Circ Physiol (2003) 0.84
The role of Rab27a in the regulation of neutrophil function. Cell Microbiol (2014) 0.83
Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane. J Biol Chem (2015) 0.81
Subcellular localization and dynamics of components of the respiratory burst oxidase. J Bioenerg Biomembr (1988) 0.76