Published in J Biol Chem on December 31, 2001
Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev (2011) 5.20
Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1). J Clin Invest (2003) 1.93
Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells. Mol Biol Cell (2004) 1.85
A general role for Rab27a in secretory cells. Mol Biol Cell (2003) 1.76
Gene expression signature of estrogen receptor alpha status in breast cancer. BMC Genomics (2005) 1.75
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J Clin Invest (2005) 1.75
Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex. Blood (2012) 1.75
Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells. Mol Biol Cell (2005) 1.69
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. EMBO Rep (2002) 1.46
Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol (2012) 1.42
Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis. Mol Biol Cell (2003) 1.41
Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes. Mol Biol Cell (2009) 1.40
shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. PLoS Genet (2016) 1.40
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Traffic (2008) 1.38
The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes. Mol Cell Biol (2003) 1.32
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. Mol Biol Cell (2004) 1.30
The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium. Traffic (2007) 1.27
Microarray analysis reveals potential mechanisms of BRMS1-mediated metastasis suppression. Clin Exp Metastasis (2007) 1.24
The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex. Mol Biol Cell (2006) 1.22
Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochem J (2007) 1.17
Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset. Am J Pathol (2008) 1.12
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood (2009) 1.11
Genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus. PLoS One (2012) 1.08
Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem (2008) 1.07
Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. J Biol Chem (2011) 1.07
Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis. Arthritis Rheumatol (2014) 1.04
Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning. Front Immunol (2014) 1.00
The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells. Proc Natl Acad Sci U S A (2002) 1.00
Analysis of gene expression identifies candidate molecular markers in nasopharyngeal carcinoma using microdissection and cDNA microarray. J Cancer Res Clin Oncol (2006) 0.99
MyRIP anchors protein kinase A to the exocyst complex. J Biol Chem (2007) 0.98
A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy. Blood (2014) 0.95
The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. Biochem J (2005) 0.95
Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis. Proc Natl Acad Sci U S A (2012) 0.94
The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame. Proc Natl Acad Sci U S A (2003) 0.93
Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors. J Leukoc Biol (2013) 0.91
Prediction and comparison of Salmonella-human and Salmonella-Arabidopsis interactomes. Chem Biodivers (2012) 0.91
High-precision mapping of protein protein interfaces: an integrated genetic strategy combining en masse mutagenesis and DNA-level parallel analysis on a yeast two-hybrid platform. Nucleic Acids Res (2007) 0.88
A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J Biol Chem (2009) 0.87
Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression. Mol Biol Cell (2012) 0.86
Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neurons. J Biol Chem (2013) 0.85
Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport. Curr Biol (2014) 0.85
Activated Cdc42-bound IQGAP1 determines the cellular endocytic site. Mol Cell Biol (2013) 0.79
The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I. Biochem J (2002) 0.79
EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells. J Biol Chem (2011) 0.78
The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest. Mol Cell Biol (2015) 0.78
Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex. J Cell Biol (2016) 0.76
Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a. J Biol Chem (2016) 0.75
Myosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro. Proc Natl Acad Sci U S A (2017) 0.75
Differing susceptibility to autophagic degradation of two LC3-binding proteins: SQSTM1/p62 and TBC1D25/OATL1. Autophagy (2016) 0.75
Molecular mechanism of docking of dense-core vesicles to the plasma membrane in neuroendocrine cells. Med Mol Morphol (2008) 0.75
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol (2002) 22.05
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell (2008) 6.66
Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol (2009) 5.44
Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat Med (2005) 4.31
DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep (2004) 3.84
Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. Cell (2005) 2.99
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76
The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature (2002) 2.75
Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell Metab (2007) 2.71
IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science (2005) 2.53
Spontaneous network activity visualized by ultrasensitive Ca(2+) indicators, yellow Cameleon-Nano. Nat Methods (2010) 2.47
Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. J Biol Chem (2002) 2.40
Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. Biochem Biophys Res Commun (2004) 2.31
Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature (2002) 2.30
Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo. J Neurosci (2011) 2.17
Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell (2008) 2.08
Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis. Neuron (2002) 2.01
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem Biophys Res Commun (2003) 1.96
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells (2005) 1.86
Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell (2003) 1.81
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. J Cell Biol (2004) 1.80
The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease. J Biol Chem (2003) 1.78
Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Genes Cells (2006) 1.76
Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics. Neuron (2009) 1.74
Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique. Neuropsychopharmacology (2006) 1.69
Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles. J Cell Biol (2003) 1.65
BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J (2002) 1.64
Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor. Mol Cell (2005) 1.62
Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells. J Cell Sci (2006) 1.62
OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. J Cell Biol (2011) 1.61
Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Mol Biol Cell (2006) 1.61
Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem (2004) 1.61
IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). Proc Natl Acad Sci U S A (2006) 1.61
Sustained activation of N-WASP through phosphorylation is essential for neurite extension. Dev Cell (2002) 1.58
Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth. Mol Cell Neurosci (2003) 1.57
The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+. Mol Pharmacol (2004) 1.56
Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. J Biol Chem (2007) 1.56
Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation. J Biol Chem (2008) 1.54
Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor. J Biol Chem (2003) 1.53
DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol Cancer Res (2003) 1.53
Rab10 in insulin-stimulated GLUT4 translocation. Biochem J (2008) 1.53
Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients. Biochem Biophys Res Commun (2004) 1.53
Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem (2006) 1.50
IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. J Biol Chem (2003) 1.47
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiol Dis (2006) 1.47
Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. J Biol Chem (2005) 1.46
IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Mol Cell (2006) 1.46
Synaptotagmin IV regulates glial glutamate release. Proc Natl Acad Sci U S A (2004) 1.46
Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. J Biol Chem (2003) 1.45
Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell (2009) 1.45
Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes. Nat Cell Biol (2004) 1.45
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J Cell Biol (2013) 1.44
Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes. Mol Cell (2009) 1.42
Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol (2012) 1.42
Zic2 controls cerebellar development in cooperation with Zic1. J Neurosci (2002) 1.42
Cdk5/p35 is required for motor coordination and cerebellar plasticity. J Neurochem (2014) 1.42
Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis. Mol Biol Cell (2003) 1.41
An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis. Curr Biol (2012) 1.41
Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes. Mol Biol Cell (2009) 1.40
Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling. J Biol Chem (2004) 1.40
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development (2007) 1.40
Rab35 regulates Arf6 activity through centaurin-β2 (ACAP2) during neurite outgrowth. J Cell Sci (2012) 1.39
DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. Int J Oncol (2005) 1.39
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Traffic (2008) 1.38
Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases. Structure (2008) 1.38
Trypsinogen hL expressed in the human lung is a new member of the trypsinogen family. Biol Pharm Bull (2003) 1.37
Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. Gene (2003) 1.36
Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis. Proc Natl Acad Sci U S A (2008) 1.35
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis. Proc Natl Acad Sci U S A (2011) 1.35
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. J Neurochem (2007) 1.34
Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor. J Biol Chem (2007) 1.34
Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proc Natl Acad Sci U S A (2009) 1.34
The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res (2010) 1.34
Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. EMBO J (2010) 1.34
Cytosolic inositol 1,4,5-trisphosphate dynamics during intracellular calcium oscillations in living cells. J Cell Biol (2006) 1.33
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest (2008) 1.32
The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes. Mol Cell Biol (2003) 1.32
A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus. J Biol Chem (2008) 1.32
Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs. Traffic (2010) 1.30
The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. J Cell Sci (2004) 1.30
Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate. J Biol Chem (2004) 1.30
Three-dimensional rearrangements within inositol 1,4,5-trisphosphate receptor by calcium. J Biol Chem (2003) 1.29
Two novel 2-aminoethyl diphenylborinate (2-APB) analogues differentially activate and inhibit store-operated Ca(2+) entry via STIM proteins. Cell Calcium (2009) 1.28
Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. Free Radic Res (2005) 1.27
Efficient targeted mutagenesis in medaka using custom-designed transcription activator-like effector nucleases. Genetics (2013) 1.26
Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites. J Biol Chem (2004) 1.26
Inositol 1,4,5-trisphosphate receptor contains multiple cavities and L-shaped ligand-binding domains. J Mol Biol (2004) 1.26
Mediolateral compartmentalization of the cerebellum is determined on the "birth date" of Purkinje cells. J Neurosci (2003) 1.26
Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev Cell (2010) 1.25
Identification of EPI64 as a GTPase-activating protein specific for Rab27A. J Biol Chem (2006) 1.25
Differential expression of Homer family proteins in the developing mouse brain. J Comp Neurol (2004) 1.25
BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. PLoS Pathog (2009) 1.24
An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites. J Biol Chem (2004) 1.23
Kinesin dependent, rapid, bi-directional transport of ER sub-compartment in dendrites of hippocampal neurons. J Cell Sci (2004) 1.23
Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling. Mol Biol Cell (2005) 1.23
L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow. J Cell Biol (2003) 1.23
Cell signaling microdomain with Na,K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations. J Biol Chem (2003) 1.23