Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27705938)

Published in Oncotarget on October 01, 2016

Authors

Shivika S Gupta1, Matthew R Zeglinski1, Sunil G Rattan1, Natalie M Landry1, Saeid Ghavami2,3, Jeffrey T Wigle4, Thomas Klonisch2, Andrew J Halayko3,5, Ian M C Dixon1

Author Affiliations

1: Department of Physiology and Pathophysiology, Institute of Cardiovascular Sciences, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
2: Department of Human Anatomy and Cell Science, Basic Medical Sciences Building, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
3: Children's Hospital Research Institute of Manitoba, John Buhler Research Centre, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
4: Department of Biochemistry and Medical Genetics, Institute of Cardiovascular Sciences, Rady Faculty of Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
5: Department of Physiology and Pathophysiology, Internal Medicine and Pediatrics and Child Health, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

Articles cited by this

Measurement of protein using bicinchoninic acid. Anal Biochem (1985) 74.03

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73

A ubiquitin-like system mediates protein lipidation. Nature (2000) 10.61

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J Biol Chem (1991) 7.04

Formation and function of the myofibroblast during tissue repair. J Invest Dermatol (2007) 6.11

Autophagy is required to maintain muscle mass. Cell Metab (2009) 4.46

Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell (2001) 4.25

Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther (2009) 4.21

Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A (2005) 3.55

Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation. Am J Pathol (2001) 3.07

Myofibroblasts differentiate from fibroblasts when plated at low density. Proc Natl Acad Sci U S A (1996) 2.63

Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling. Cardiovasc Res (2008) 2.22

Lifetime costs of medical care after heart failure diagnosis. Circ Cardiovasc Qual Outcomes (2010) 2.19

Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology (2012) 2.11

Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat Rev Cardiol (2012) 2.03

Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation (2012) 1.91

Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts. Hypertension (2002) 1.87

Scraping fibrosis: expressway to the core of fibrosis. Nat Med (2011) 1.82

Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal (2011) 1.76

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation. Am J Physiol Gastrointest Liver Physiol (2011) 1.70

Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy (2010) 1.70

p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts. Hepatology (2003) 1.55

Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein. J Cell Mol Med (2008) 1.54

Quantitation of "autophagic flux" in mature skeletal muscle. Autophagy (2010) 1.53

Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles. Autophagy (2010) 1.51

Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat Commun (2013) 1.46

Extracellular matrix remodeling following myocardial injury. Ann Med (2003) 1.41

Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts. Dev Dyn (2010) 1.33

The role of autophagy emerging in postinfarction cardiac remodelling. Cardiovasc Res (2011) 1.27

Essential role for autophagy in life span extension. J Clin Invest (2015) 1.25

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition. Carcinogenesis (2013) 1.17

Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. Am J Physiol Heart Circ Physiol (2000) 1.15

Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts. Cell Death Dis (2015) 1.07

Role of hypoxia and autophagy in MDA-MB-231 invasiveness. J Cell Physiol (2010) 1.05

Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle (2013) 1.04

Origin, development, and differentiation of cardiac fibroblasts. J Mol Cell Cardiol (2013) 1.03

Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase. Cell Death Dis (2013) 1.01

Autophagy: an affair of the heart. Heart Fail Rev (2013) 0.97

Clinical characteristics and outcome of hospitalized patients with heart failure in Japan. Circ J (2006) 0.96

Expression of Gi-2 alpha and Gs alpha in myofibroblasts localized to the infarct scar in heart failure due to myocardial infarction. Cardiovasc Res (1999) 0.88

Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility. Am J Physiol Cell Physiol (2010) 0.87

Differential and combined effects of cardiotrophin-1 and TGF-beta1 on cardiac myofibroblast proliferation and contraction. Am J Physiol Heart Circ Physiol (2007) 0.87

Mechanical tension stimulates the transdifferentiation of fibroblasts into myofibroblasts in human burn scars. Burns (2008) 0.86

p53 mediates autophagy and cell death by a mechanism contingent on Bnip3. Hypertension (2013) 0.85

Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation. Cell Death Dis (2015) 0.84

Role of autophagy in myocardial reperfusion injury. Front Biosci (Elite Ed) (2010) 0.82

Chloroquine improved carbon tetrachloride-induced liver fibrosis through its inhibition of the activation of hepatic stellate cells: role of autophagy. Biol Pharm Bull (2014) 0.82

MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation. Autophagy (2015) 0.78

Autophagy in the heart: too much of a good thing? J Cardiovasc Pharmacol (2012) 0.78

Chloroquine inhibits MGC803 gastric cancer cell migration via the Toll-like receptor 9/nuclear factor kappa B signaling pathway. Mol Med Rep (2014) 0.76