Published in Nature on November 23, 2000
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J (2007) 9.65
Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J (2001) 8.84
Autophagy: molecular machinery for self-eating. Cell Death Differ (2005) 8.46
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69
The molecular machinery of autophagy: unanswered questions. J Cell Sci (2005) 6.67
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell (2008) 6.66
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol (2006) 6.47
Pancreatic cancers require autophagy for tumor growth. Genes Dev (2011) 6.17
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med (2009) 5.43
The role of autophagy in neurodegenerative disease. Nat Med (2013) 4.46
Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell (2008) 4.41
The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell (2008) 4.00
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat Rev Mol Cell Biol (2009) 3.95
Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem (2001) 3.90
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell (2005) 3.71
Autophagy in the eukaryotic cell. Eukaryot Cell (2002) 3.61
The dynamic nature of autophagy in cancer. Genes Dev (2011) 3.57
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature (2010) 3.55
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 3.52
Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene. Plant Physiol (2002) 3.47
Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat Cell Biol (2011) 3.45
Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion. Mol Biol Cell (2001) 3.41
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Plant Cell (2004) 3.17
The machinery of macroautophagy. Cell Res (2013) 3.13
ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell (2010) 2.83
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem (2002) 2.80
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78
High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell (2011) 2.77
The regulation of autophagy - unanswered questions. J Cell Sci (2011) 2.73
PpAtg30 tags peroxisomes for turnover by selective autophagy. Dev Cell (2008) 2.73
Autophagy is an immediate macrophage response to Legionella pneumophila. Cell Microbiol (2005) 2.68
Autophagy: a forty-year search for a missing membrane source. PLoS Biol (2006) 2.64
The molecular mechanism of autophagy. Mol Med (2003) 2.63
Vacuolar localization of oligomeric alpha-mannosidase requires the cytoplasm to vacuole targeting and autophagy pathway components in Saccharomyces cerevisiae. J Biol Chem (2001) 2.58
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol (2012) 2.56
Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Mol Biol Cell (2003) 2.48
LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy. Mol Cell (2012) 2.41
Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood (2009) 2.39
The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J (2009) 2.25
Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris. Mol Biol Cell (2001) 2.21
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One (2009) 2.20
Atg9 vesicles are an important membrane source during early steps of autophagosome formation. J Cell Biol (2012) 2.12
Atg8: an autophagy-related ubiquitin-like protein family. Genome Biol (2011) 2.04
An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal (2013) 2.04
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J (2004) 1.99
Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways. J Biol Chem (2001) 1.99
Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology (2011) 1.96
The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.94
Ubiquitination in postsynaptic function and plasticity. Annu Rev Cell Dev Biol (2010) 1.94
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J Cell Sci (2009) 1.92
Cryptococcus neoformans gene expression during murine macrophage infection. Eukaryot Cell (2005) 1.89
Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J Cell Biol (2008) 1.85
Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy. EMBO J (2012) 1.83
The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science (2012) 1.82
Autophagy is essential for mouse sense of balance. J Clin Invest (2010) 1.81
The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella. Mol Biol Cell (2011) 1.79
Autophagy in yeast: mechanistic insights and physiological function. Microbiol Mol Biol Rev (2001) 1.78
Autophagic processes in yeast: mechanism, machinery and regulation. Genetics (2013) 1.78
Viral avoidance and exploitation of the ubiquitin system. Nat Cell Biol (2009) 1.77
p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci U S A (2010) 1.77
A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability. Cell Host Microbe (2014) 1.76
The cell biology of autophagy in metazoans: a developing story. Development (2008) 1.76
Calpain is required for macroautophagy in mammalian cells. J Cell Biol (2006) 1.75
Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy. EMBO Rep (2006) 1.72
Modification of cellular autophagy protein LC3 by poliovirus. J Virol (2007) 1.71
Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat Cell Biol (2008) 1.70
The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. Elife (2013) 1.66
Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. J Biol Chem (2002) 1.66
The ATG12-conjugating enzyme ATG10 Is essential for autophagic vesicle formation in Arabidopsis thaliana. Genetics (2008) 1.63
OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. J Cell Biol (2011) 1.61
Transcriptome profiling of the response of Arabidopsis suspension culture cells to Suc starvation. Plant Physiol (2004) 1.57
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy (2009) 1.57
Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages. J Cell Sci (2012) 1.57
The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases. Biochim Biophys Acta (2009) 1.56
Aut5/Cvt17p, a putative lipase essential for disintegration of autophagic bodies inside the vacuole. J Bacteriol (2001) 1.56
Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy. J Cell Biol (2008) 1.55
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol (2002) 1.54
Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes. Circ Res (2011) 1.53
Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae. Annu Rev Biochem (2011) 1.51
Regulation of macroautophagy in Saccharomyces cerevisiae. Semin Cell Dev Biol (2010) 1.51
Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8. J Cell Biol (2010) 1.50
Historical landmarks of autophagy research. Cell Res (2013) 1.49
Role of microtubules in extracellular release of poliovirus. J Virol (2009) 1.49
Starving neurons show sex difference in autophagy. J Biol Chem (2008) 1.49
In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J Cell Biol (2008) 1.48
Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast. Mol Biol Cell (2003) 1.47
Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nat Cell Biol (2014) 1.46
Inhibition of target of rapamycin signaling and stress activate autophagy in Chlamydomonas reinhardtii. Plant Physiol (2010) 1.46
PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans. J Clin Invest (2008) 1.45
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol (2001) 13.98
Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett (1993) 13.48
A protein conjugation system essential for autophagy. Nature (1998) 12.71
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem (1998) 10.77
Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol (2000) 9.61
Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J Cell Biol (1999) 9.33
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J (2001) 8.84
Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J Cell Biol (1992) 8.33
Vacuolar import of proteins and organelles from the cytoplasm. Annu Rev Cell Dev Biol (1999) 7.75
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol (2001) 7.68
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol (2000) 7.48
Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep (2001) 7.13
Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun (1995) 5.89
Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome. J Cell Biol (1997) 5.57
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature (1997) 5.55
Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene (1997) 5.53
Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization. J Cell Biol (1994) 5.41
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep (2001) 5.32
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ (2006) 5.18
A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem (1998) 5.07
Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole. Proc Natl Acad Sci U S A (1996) 4.97
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci U S A (1998) 4.82
Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell (2000) 4.69
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature (1995) 4.68
Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol Biol Cell (1999) 4.68
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways. J Cell Biol (2000) 4.30
Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J Cell Biol (2001) 4.25
The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells. Mol Biol Cell (2000) 4.22
Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature (2000) 4.01
Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. EMBO J (1999) 3.97
Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem (1998) 3.93
Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae. Gene (1997) 3.88
Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism. J Cell Biol (1997) 3.81
Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. EMBO J (1999) 3.70
Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol (1998) 3.62
Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion. Mol Biol Cell (2001) 3.41
Intravenous recombinant tissue plasminogen activator in acute carotid artery territory stroke. Neurology (1992) 3.40
The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. J Biol Chem (2000) 3.33
Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J Biol Chem (2000) 3.25
A role for hematopoietic stem cells in promoting angiogenesis. Cell (2000) 3.25
Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene. Nature (1994) 3.24
Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature (1994) 3.20
Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin. J Biol Chem (1983) 3.08
The isolation and characterization of an in vivo recombinant between the filamentous bacteriophage f1 and the plasmid pSC101. Virology (1978) 2.90
Properties of H+-translocating adenosine triphosphatase in vacuolar membranes of SAccharomyces cerevisiae. J Biol Chem (1981) 2.81
Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: not apoptosis but DNA repair. Circulation (1999) 2.80
Amino-acid sequence of a heat-stable enterotoxin produced by human enterotoxigenic Escherichia coli. Eur J Biochem (1982) 2.78
In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. EMBO J (1995) 2.74
Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature (1996) 2.70
Analysis of the membrane structures involved in autophagy in yeast by freeze-replica method. Cell Struct Funct (1995) 2.69
Calcium transport driven by a proton motive force in vacuolar membrane vesicles of Saccharomyces cerevisiae. J Biol Chem (1983) 2.62
Farnesylated gamma-subunit of photoreceptor G protein indispensable for GTP-binding. Nature (1990) 2.57
Purification and properties of H+-translocating, Mg2+-adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae. J Biol Chem (1985) 2.54
Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res (1999) 2.52
Active transport of basic amino acids driven by a proton motive force in vacuolar membrane vesicles of Saccharomyces cerevisiae. J Biol Chem (1981) 2.51
Membrane markers of endoplasmic reticulum preserved in autophagic vacuolar membranes isolated from leupeptin-administered rat liver. J Biol Chem (1991) 2.51
Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. I. Isolation and characterization of two classes of vam mutants. J Biol Chem (1992) 2.45
Considerable time from the onset of plaque rupture and/or thrombi until the onset of acute myocardial infarction in humans: coronary angiographic findings within 1 week before the onset of infarction. Circulation (2000) 2.42
Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice. J Cell Biol (1998) 2.40
BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol (2000) 2.40